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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | WITKIN, Steven S. | - |
dc.contributor.author | CHERVENAK, Joseph | - |
dc.contributor.author | BONGIOVANNI, Ann Marie | - |
dc.contributor.author | HERWAY, Catherine | - |
dc.contributor.author | LINHARES, Iara M. | - |
dc.contributor.author | SKUPSKI, Daniel | - |
dc.date.accessioned | 2013-07-30T17:17:29Z | - |
dc.date.available | 2013-07-30T17:17:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, v.67, n.1, p.28-33, 2012 | - |
dc.identifier.issn | 1046-7408 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1246 | - |
dc.description.abstract | Problem We evaluated the influence of amniotic fluid (AF) on immune mediator production by mononuclear leukocytes. Method of study Thirty mid-gestation AFs were incubated with peripheral blood mononuclear cells (PBMCs) in the presence or absence of lipopolysaccharide (LPS). Supernatants were tested for interleukin (IL) -6, 10, 12, 23, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein (MCP)-1. Results Endogenous mediator production was minimal or non-detectable. AF stimulated endogenous MCP-1, IL-6 and TNF-alpha release. In the presence of LPS, production of MCP-1 and IL-10 by PBMCs was enhanced eightto ninefold by AF. Release of IL-6 and IL-23 was enhanced less than twofold by the addition of AF while TNF-alpha production was unchanged. AF-stimulated mediator production was similar irrespective of pregnancy outcome. Conclusion Selective AF stimulation of LPS-mediated MCP-1 and IL-10 release may be a mechanism to promote antibody production and the influx of phagocytic cells to engulf pathogens while downregulating the production of pro-inflammatory cytokines. | - |
dc.language.iso | eng | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.ispartof | American Journal of Reproductive Immunology | - |
dc.rights | restrictedAccess | - |
dc.subject | Amniotic fluid | - |
dc.subject | cytokines | - |
dc.subject | immune regulation | - |
dc.subject | lipopolysaccharide | - |
dc.subject.other | monocyte chemotactic protein-1 | - |
dc.subject.other | pregnant rhesus-monkeys | - |
dc.subject.other | necrosis-factor-alpha | - |
dc.subject.other | preterm labor | - |
dc.subject.other | microbial invasion | - |
dc.subject.other | acquired-immunity | - |
dc.subject.other | innate | - |
dc.subject.other | interleukin-1-beta | - |
dc.subject.other | infection | - |
dc.subject.other | cytokine | - |
dc.title | Influence of Mid-Trimester Amniotic Fluid on Endogenous and Lipopolysaccharide-Mediated Responses of Mononuclear Lymphoid Cells | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY-BLACKWELL | - |
dc.identifier.doi | 10.1111/j.1600-0897.2011.01032.x | - |
dc.identifier.pmid | 21682792 | - |
dc.subject.wos | Immunology | - |
dc.subject.wos | Reproductive Biology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | WITKIN, Steven S.:Cornell Univ, Weill Med Coll, Div Immunol & Infect Dis, Dept Obstet & Gynecol, New York, NY 10065 USA | - |
hcfmusp.author.external | HERWAY, Catherine:New York Hosp, Queens Med Ctr, Dept Obstet & Gynecol, New York, NY 10021 USA | - |
hcfmusp.author.external | SKUPSKI, Daniel:New York Hosp, Queens Med Ctr, Dept Obstet & Gynecol, New York, NY 10021 USA | - |
hcfmusp.description.beginpage | 28 | - |
hcfmusp.description.endpage | 33 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 67 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000297920700004 | - |
hcfmusp.origem.id | 2-s2.0-83555173492 | - |
hcfmusp.publisher.city | MALDEN | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 5 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/58 |
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