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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | INOCENTE, Clara | - |
dc.contributor.author | ARNULF, Isabelle | - |
dc.contributor.author | BASTUJI, Helene | - |
dc.contributor.author | THIBAULT-STOLL, Anne | - |
dc.contributor.author | RAOUX, Aude | - |
dc.contributor.author | REIMAO, Rubens | - |
dc.contributor.author | LIN, Jian-Sheng | - |
dc.contributor.author | FRANCO, Patricia | - |
dc.date.accessioned | 2013-07-30T17:17:45Z | - |
dc.date.available | 2013-07-30T17:17:45Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | CLINICAL NEUROPHARMACOLOGY, v.35, n.2, p.55-60, 2012 | - |
dc.identifier.issn | 0362-5664 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1344 | - |
dc.description.abstract | Objective: Narcolepsy is a rare disabling sleep disorder characterized by excessive daytime sleepiness and cataplexy (sudden loss of muscle tone). Drugs such as pitolisant, which block histamine H3 autoreceptors, constitute a newly identified class of stimulants because they increase brain histamine and enhance wakefulness in animal and human adult narcolepsy. Methods: We report our experience with the off-label use of pitolisant in 4 teenagers with narcolepsy/cataplexy with severe daytime sleepiness, refractory to available treatments (modafinil, methylphenidate, mazindol, sodium oxybate, and D-amphetamine). Results: All teenagers developed their disease during childhood (11.3 +/- 2.4 years; 50% boys) and were 17.3 +/- 0.8 years old at the time of pitolisant therapy. Pitolisant treatment was increased from 10 to 30 mg (n = 1) and 40 mg (n = 3). The adapted Epworth Sleepiness Score decreased from 14.3 +/- 1.1 to 9.5 +/- 2.9 (P = 0.03) with pitolisant alone to 7 +/- 3.4 when combined with mazindol (n = 1), methylphenidate (n = 1), or sodium oxybate plus modafinil (n = 1). Mean sleep onset latency increased from 31 +/- 14 minutes to 36 +/- 8 minutes (P = 0.21) on the maintenance of wakefulness test. The severity and frequency of cataplexy were slightly improved. Adverse effects were minor (insomnia, headache, hot flushes, leg pain, and hallucinations) and transitory, except for insomnia, which persisted in 2 teenagers. The benefit was maintained after a mean of 13 months. Conclusions: Pitolisant could constitute an acceptable alternative for the treatment of refractory sleepiness in teenagers with narcolepsy. | - |
dc.language.iso | eng | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.relation.ispartof | Clinical Neuropharmacology | - |
dc.rights | restrictedAccess | - |
dc.subject | narcolepsy | - |
dc.subject | sleep disorders | - |
dc.subject | histamine | - |
dc.subject | wakefulness | - |
dc.subject.other | excessive daytime sleepiness | - |
dc.subject.other | sodium oxybate | - |
dc.subject.other | children | - |
dc.subject.other | restriction | - |
dc.subject.other | adolescents | - |
dc.subject.other | neurons | - |
dc.subject.other | onset | - |
dc.title | Pitolisant, an Inverse Agonist of the Histamine H3 Receptor: An Alternative Stimulant for Narcolepsy-Cataplexy in Teenagers With Refractory Sleepiness | - |
dc.type | article | - |
dc.rights.holder | Copyright LIPPINCOTT WILLIAMS & WILKINS | - |
dc.identifier.doi | 10.1097/WNF.0b013e318246879d | - |
dc.identifier.pmid | 22356925 | - |
dc.subject.wos | Clinical Neurology | - |
dc.subject.wos | Pharmacology & Pharmacy | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | INOCENTE, Clara:Univ Lyon 1, CRNL, CNRS, INSERM,UMR5292,U1028, F-69500 Lyon, France; Univ Sao Paulo, Sch Med, Clin Hosp, Div Clin Neurol,Sleep Med Adv Res Grp, Sao Paulo, Brazil | - |
hcfmusp.author.external | ARNULF, Isabelle:Grp Hosp Pitie Salpetriere, AP HP, Unite Pathol Sommeil, F-75634 Paris, France; Univ Paris 06, Ctr Rech, Inst Cerveau & Moelle Epiniere, CNRS,UMR S975,UMR7225, Paris, France; INSERM, U975, Paris, France; Natl Reference Ctr Orphan Dis Narcolepsy Idiopath, CNR Narcolepsie Hypersomnie, Paris, France | - |
hcfmusp.author.external | BASTUJI, Helene:Univ Lyon 1, Hop Neurol, CRNL, INSERM,Serv Hypnol,CNRS,UMR5292,U1028, F-69500 Lyon, France | - |
hcfmusp.author.external | THIBAULT-STOLL, Anne:Clin St BARBE, Ctr Sommeil Epilepsie, Strasbourg, France | - |
hcfmusp.author.external | RAOUX, Aude:Univ Lyon 1, Hop Femme Mere Enfant, Pediat Sleep Unit, F-69500 Lyon, France; Univ Lyon 1, CRNL, CNRS, INSERM,UMR5292,U1028, F-69500 Lyon, France; Natl Reference Ctr Orphan Dis Narcolepsy Idiopath, CNR Narcolepsie Hypersomnie, Paris, France | - |
hcfmusp.author.external | LIN, Jian-Sheng:Univ Lyon 1, CRNL, CNRS, INSERM,UMR5292,U1028, F-69500 Lyon, France | - |
hcfmusp.author.external | FRANCO, Patricia:Univ Lyon 1, Hop Femme Mere Enfant, Pediat Sleep Unit, F-69500 Lyon, France; Univ Lyon 1, CRNL, CNRS, INSERM,UMR5292,U1028, F-69500 Lyon, France; Natl Reference Ctr Orphan Dis Narcolepsy Idiopath, CNR Narcolepsie Hypersomnie, Paris, France | - |
hcfmusp.description.beginpage | 55 | - |
hcfmusp.description.endpage | 60 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 35 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | WOS:000301866900001 | - |
hcfmusp.origem.id | 2-s2.0-84862791691 | - |
hcfmusp.publisher.city | PHILADELPHIA | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.citation.scopus | 87 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC |
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