Detection of Cerebral Vasculopathy by Transcranial Doppler in Children With Neurofibromatosis Type 1
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Citações na Scopus
3
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
SAGE PUBLICATIONS INC
Autores
PASCHOAL, Joelma Karin Sagica Fernandes
LIMA, Fernanda Teresa de
PINHO, Ricardo Silva
VILANOVA, Luiz Celso Pereira
MASRUHA, Marcelo Rodrigues
Citação
JOURNAL OF CHILD NEUROLOGY, v.31, n.3, p.351-356, 2016
Resumo
Neurofibromatosis type 1 is characterized by nerve sheath neurofibromas associated with a number of additional clinical features, including cerebrovascular disease. The aim of this study was to use transcranial Doppler as a screening method for identifying cerebral vasculopathy in children with neurofibromatosis type 1. Forty children with neurofibromatosis type 1, aged 5 to 18 years old, were examined by transcranial Doppler. Patients presenting with hemodynamic features of arterial stenosis/occlusion on transcranial Doppler underwent magnetic resonance angiography to confirm the findings. Magnetic resonance angiography was performed on 4 children who exhibited a transcranial Doppler hemodynamic pattern indicative of cerebral vasculopathy. Among these cases, 2 presented internal carotid artery stenosis/occlusion, 1 had bilateral middle cerebral artery stenosis, and 1 presented a normal magnetic resonance angiography result. Transcranial Doppler can be used routinely in the investigation of cerebrovascular disease in neurofibromatosis type 1 patients, where magnetic resonance angiography can be subsequently applied to confirm the diagnosis, further contributing to the prevention of cerebrovascular events.
Palavras-chave
transcranial Doppler, neurofibromatosis, cerebrovascular disease
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