Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease
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Citações na Scopus
39
Tipo de produção
article
Data de publicação
2016
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS INC
Autores
LAUGIER, Laurie
TEIXEIRA, Priscila Camillo
CABANTOUS, Sandrine
Citação
JOURNAL OF INFECTIOUS DISEASES, v.214, n.1, p.161-165, 2016
Resumo
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
Palavras-chave
dilated, cardiomyopathy, Chagas disease, lncRNA, MIAT, biomarker
Referências
- Eicher JD, 2016, PLATELETS, V27, P230, DOI 10.3109/09537104.2015.1083543
- Esteller M, 2011, NAT REV GENET, V12, P861, DOI 10.1038/nrg3074
- Grote P, 2013, RNA BIOL, V10, P1579, DOI 10.4161/rna.26165
- Han P, 2014, NATURE, V514, P102, DOI 10.1038/nature13596
- Ishii N, 2006, J HUM GENET, V51, P1087, DOI 10.1007/s10038-006-0070-9
- Klattenhoff CA, 2013, CELL, V152, P570, DOI 10.1016/j.cell.2013.01.003
- Marin JA, 2007, CIRCULATION, V115, P1109, DOI 10.1161/CIRCULATIONAHA.106.624296
- Navarro IC, 2015, PLOS NEGLECT TROP D, V9, DOI 10.1371/journal.pntd.0003828
- Ferreira LRP, 2014, INT J CARDIOL, V175, P409, DOI 10.1016/j.ijcard.2014.05.019
- Rao SQ, 2015, SCHIZOPHR RES, V166, P125, DOI 10.1016/j.schres.2015.04.032
- Schofield CJ, 2006, TRENDS PARASITOL, V22, P583, DOI 10.1016/j.pt.2006.09.011
- Silva CP, 2008, ARQ BRAS CARDIOL, V91, P358
- Taft RJ, 2010, J PATHOL, V220, P126, DOI 10.1002/path.2638
- Yan BA, 2015, CIRC RES, V116, P1143, DOI 10.1161/CIRCRESAHA.116.305510
- Zhou L, 2015, BIOCHEM BIOPH RES CO, V468, P726, DOI 10.1016/j.bbrc.2015.11.023