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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | MINAME, Marcio H. | - |
dc.contributor.author | SANTOS, Raul D. | - |
dc.date.accessioned | 2013-09-23T16:36:35Z | - |
dc.date.available | 2013-09-23T16:36:35Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | CLINICAL LIPIDOLOGY, v.8, n.2, p.231-242, 2013 | - |
dc.identifier.issn | 1758-4299 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/1818 | - |
dc.description.abstract | Heterozygous familial hypercholesterolennia (FH) is characterized by high LDL cholesterol levels and premature coronary heart disease onset. Nonetheless, the course of coronary disease events in heterozygous FH subjects is variable. The presence and severity of subclinical atherosclerosis predicts cardiovascular event onset and may help reclassify the risk of clinical events in the general population. In this review, we discuss the possible use of subclinical coronary, carotid and aortic atherosclerosis testing in heterozygous FH subjects for cardiovascular risk stratification and treatment. Many FH subjects present an increased and precocious burden of subclinical vascular disease in comparison to normolipidemic subjects. These subjects may be at higher risk of cardiovascular events and might deserve more aggressive lipid-lowering treatment. Nevertheless, routine screening of imaging biomarkers for FH subjects in clinical practice remains to be determined in prospective trials. | - |
dc.language.iso | eng | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.relation.ispartof | Clinical Lipidology | - |
dc.rights | restrictedAccess | - |
dc.subject | atherosclerosis | - |
dc.subject | cardiovascular risk stratification | - |
dc.subject | carotid intima-media thickness | - |
dc.subject | carotid ultrasound | - |
dc.subject | computed tomography | - |
dc.subject | coronary calcification | - |
dc.subject | familial hypercholesterolemia | - |
dc.subject | MRI | - |
dc.subject | statin | - |
dc.subject | subclinical atherosclerosis | - |
dc.subject | ultrasound | - |
dc.subject.other | coronary-artery calcium | - |
dc.subject.other | intima-media thickness | - |
dc.subject.other | electron-beam tomography | - |
dc.subject.other | all-cause mortality | - |
dc.subject.other | international multicenter registry | - |
dc.subject.other | ct angiography evaluation | - |
dc.subject.other | lipid-lowering therapy | - |
dc.subject.other | double-blind trial | - |
dc.subject.other | heart-disease | - |
dc.subject.other | cardiovascular-disease | - |
dc.title | Imaging biomarkers to track subclinical atherosclerosis in heterozygous familial hypercholesterolemia | - |
dc.type | article | - |
dc.rights.holder | Copyright FUTURE MEDICINE LTD | - |
dc.identifier.doi | 10.2217/CLP.13.4 | - |
dc.subject.wos | Biochemistry & Molecular Biology | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 231 | - |
hcfmusp.description.endpage | 242 | - |
hcfmusp.description.issue | 2 | - |
hcfmusp.description.volume | 8 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84875919777 | - |
hcfmusp.origem.id | WOS:000317090100013 | - |
hcfmusp.publisher.city | LONDON | - |
hcfmusp.publisher.country | ENGLAND | - |
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dc.description.index | PubMed | - |
hcfmusp.citation.scopus | 2 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
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