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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | SANTOS-OLIVEIRA, Joanna R. | - |
dc.contributor.author | REGIS, Eduardo G. | - |
dc.contributor.author | GIACOIA-GRIPP, Carmem B. W. | - |
dc.contributor.author | VALVERDE, Joanna G. | - |
dc.contributor.author | ALEXANDRINO-DE-OLIVEIRA, Priscilla | - |
dc.contributor.author | LINDOSO, Jose Angelo L. | - |
dc.contributor.author | GOTO, Hiro | - |
dc.contributor.author | OLIVEIRA-NETO, Manoel P. | - |
dc.contributor.author | GUERRA, Jorge O. | - |
dc.contributor.author | GRINSZTEJN, Beatriz | - |
dc.contributor.author | JERONIMO, Selma B. | - |
dc.contributor.author | MORGADO, Mariza G. | - |
dc.contributor.author | DA-CRUZ, Alda M. | - |
dc.date.accessioned | 2013-09-23T16:43:50Z | - |
dc.date.available | 2013-09-23T16:43:50Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | JOURNAL OF INFECTIOUS DISEASES, v.208, n.1, p.57-66, 2013 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/2117 | - |
dc.description.abstract | Background. Leishmania infection is a cofactor in the heightened cellular activation observed in patients with American visceral leishmaniasis and human immunodeficiency virus type 1 (HIV) infection, with or without progression to AIDS (AVL/HIV). Thus, the persistence of a high parasite load despite antileishmanial therapy could be responsible for the continued immune stimulation. Methods. CD8(+) T cells expressing CD38, parasite load, lipopolysaccharide (LPS), soluble CD14, macrophage migration inhibitory factor (MIF), intestinal fatty acid-binding protein (IFABP), and proinflammatory cytokines (interleukin 1 beta, interleukin 6, interleukin 8, interleukin 17, interferon gamma, and tumor necrosis factor) were measured in 17 patients with AVL/HIV, 16 with HIV, and 14 healthy subjects (HS). Results. Lower Leishmania parasitemia was observed after antileishmanial and antiretroviral therapies. However, higher levels of CD38(+) on CD8(+) T cells were observed in both clinical phases of leishmaniasis, compared with HIV cases. AVL/HIV and HIV patients showed higher levels of LPS and IFABP than HS. Proinflammatory cytokine levels were significantly augmented in patients with active coinfection, as well as those with remission of Leishmania infection. LPS levels and Leishmania infection were positively correlated with CD38 expression on CD8(+) T cells and with IL-6 and IL-8 levels. Conclusions. LPS levels along with the immune consequences of Leishmania infection were associated with elevated cellular activation in coinfected patients. As a consequence, secondary chemoprophylaxis for leishmaniasis or even the use of antiinflammatory drugs or antibiotics may be considered for improving the prognosis of AVL/HIV. | - |
dc.description.sponsorship | Programa Nacional de DST/AIDS, Ministerio da Saude [ED00095/2007] | - |
dc.description.sponsorship | Instituto Oswaldo Cruz | - |
dc.description.sponsorship | FAPERJ [FAPERJ nota 10] | - |
dc.description.sponsorship | CNPq | - |
dc.language.iso | eng | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.relation.ispartof | Journal of Infectious Diseases | - |
dc.rights | restrictedAccess | - |
dc.subject | visceral leishmaniasis-HIV/AIDS coinfection | - |
dc.subject | microbial translocation | - |
dc.subject | inflammatory cytokines | - |
dc.subject.other | t-cells | - |
dc.subject.other | immune activation | - |
dc.subject.other | gastrointestinal-tract | - |
dc.subject.other | infected patients | - |
dc.subject.other | kala-azar | - |
dc.subject.other | disease | - |
dc.subject.other | virus | - |
dc.subject.other | cytokines | - |
dc.subject.other | aids | - |
dc.subject.other | replication | - |
dc.title | Microbial Translocation Induces an Intense Proinflammatory Response in PatientsWith Visceral Leishmaniasis and HIV Type 1 Coinfection | - |
dc.type | article | - |
dc.rights.holder | Copyright OXFORD UNIV PRESS INC | - |
dc.identifier.doi | 10.1093/infdis/jit135 | - |
dc.identifier.pmid | 23539743 | - |
dc.subject.wos | Immunology | - |
dc.subject.wos | Infectious Diseases | - |
dc.subject.wos | Microbiology | - |
dc.type.category | original article | - |
dc.type.version | publishedVersion | - |
hcfmusp.author.external | SANTOS-OLIVEIRA, Joanna R.:Fiocruz MS, Inst Oswaldo Cruz, Lab Interdisciplinar Pesquisas Med, BR-21045900 Rio De Janeiro, RJ, Brazil | - |
hcfmusp.author.external | REGIS, Eduardo G.:Fiocruz MS, Inst Oswaldo Cruz, Lab Pesquisa Timo, BR-21045900 Rio De Janeiro, RJ, Brazil | - |
hcfmusp.author.external | GIACOIA-GRIPP, Carmem B. W.:Fiocruz MS, Inst Oswaldo Cruz, Lab Aids & Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil | - |
hcfmusp.author.external | VALVERDE, Joanna G.:Univ Fed Rio Grande do Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil | - |
hcfmusp.author.external | ALEXANDRINO-DE-OLIVEIRA, Priscilla:Univ Fed Mato Grosso do Sul, Univ Hosp, Hosp Dia Profa Esterina Corsini, Campo Grande, Brazil | - |
hcfmusp.author.external | OLIVEIRA-NETO, Manoel P.:Fiocruz MS, IPEC, Inst Pesquisa Clin Evandro Chagas, BR-21045900 Rio De Janeiro, RJ, Brazil | - |
hcfmusp.author.external | GUERRA, Jorge O.:Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil | - |
hcfmusp.author.external | GRINSZTEJN, Beatriz:Fiocruz MS, IPEC, Inst Pesquisa Clin Evandro Chagas, BR-21045900 Rio De Janeiro, RJ, Brazil | - |
hcfmusp.author.external | JERONIMO, Selma B.:Univ Fed Rio Grande do Norte, Dept Bioquim, BR-59072970 Natal, RN, Brazil | - |
hcfmusp.author.external | MORGADO, Mariza G.:Fiocruz MS, Inst Oswaldo Cruz, Lab Aids & Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil | - |
hcfmusp.author.external | DA-CRUZ, Alda M.:Fiocruz MS, Inst Oswaldo Cruz, Lab Interdisciplinar Pesquisas Med, BR-21045900 Rio De Janeiro, RJ, Brazil; Univ Estado Rio de Janeiro, Fac Ciencias Med, Disciplina Parasitol, Rio De Janeiro, Brazil | - |
hcfmusp.description.beginpage | 57 | - |
hcfmusp.description.endpage | 66 | - |
hcfmusp.description.issue | 1 | - |
hcfmusp.description.volume | 208 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84878611218 | - |
hcfmusp.origem.id | WOS:000319830300010 | - |
hcfmusp.publisher.city | CARY | - |
hcfmusp.publisher.country | USA | - |
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dc.description.index | MEDLINE | - |
hcfmusp.remissive.sponsorship | CNPq | - |
hcfmusp.remissive.sponsorship | FAPERJ | - |
hcfmusp.remissive.sponsorship | Ministério da Saúde | - |
hcfmusp.citation.scopus | 32 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MPR Artigos e Materiais de Revistas Científicas - LIM/38 Artigos e Materiais de Revistas Científicas - ODS/03 |
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