Effect of creatine supplementation on measured glomerular filtration rate in postmenopausal women

Carregando...
Imagem de Miniatura
Citações na Scopus
25
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
Citação
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME, v.36, n.3, p.419-422, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
We aimed to investigate whether creatine supplementation affects the measured glomerular filtration rate in postmenopausal women (age, 58 +/- 3 years). Subjects were randomly assigned to receive either creatine (20 g(.)day(-1) for 1 week and 5 g(.)day(-1) thereafter) or a placebo. Kidney function was assessed at baseline and after 12 weeks. [Cr-51] EDTA clearance remained unchanged (CR-PRE: 86.16 +/- 14.36 mL(.)min(-1) per 1.73 m(2), POST: 87.25 +/- 17.60 mL(.)min(-1) per 1.73 m(2); PL-PRE: 85.15 +/- 8.54 mL(.)min(-1) per 1.73 m(2), POST: 87.18 +/- 9.64 mL(.)min(-1) per 1.73 m(2); p = 0.81). Thus, we concluded that creatine supplementation does not affect glomerular filtration rate in postmenopausal women.
Palavras-chave
kidney function, safety, [(51)]CrEDTA clearance, creatinine, nutritional supplements, adverse effects
Referências
  1. Kreider RB, 2003, MOL CELL BIOCHEM, V244, P95, DOI 10.1023/A:1022469320296
  2. Wyss M, 2000, PHYSIOL REV, V80, P1107
  3. Poortmans JR, 2005, MED SCI SPORT EXER, V37, P1717, DOI 10.1294/01.mss.0000176398.64189.e6
  4. Poortmans JR, 1999, MED SCI SPORT EXER, V31, P1108, DOI 10.1097/00005768-199908000-00005
  5. Gualano B, 2008, EUR J APPL PHYSIOL, V103, P33, DOI 10.1007/s00421-007-0669-3
  6. Koshy KM, 1999, NEW ENGL J MED, V340, P814
  7. Pritchard NR, 1998, LANCET, V351, P1252, DOI 10.1016/S0140-6736(05)79319-3
  8. Gualano B, 2011, EUR J APPL PHYSIOL, V111, P749, DOI 10.1007/s00421-010-1676-3
  9. Poortmans JR, 2000, SPORTS MED, V30, P155, DOI 10.2165/00007256-200030030-00002
  10. Poortmans JR, 1997, EUR J APPL PHYSIOL O, V76, P566, DOI 10.1007/s004210050291
  11. Gualano B, 2010, AMINO ACIDS, V38, P31, DOI 10.1007/s00726-009-0263-6
  12. Levey AS, 2003, ANN INTERN MED, V139, P137
  13. Gualano B, 2010, AM J KIDNEY DIS, V55, pE7, DOI 10.1053/j.ajkd.2009.10.053
  14. Gualano B, 2010, MED SCI SPORTS EXERC
  15. Kuehl Kerry, 1998, Medicine and Science in Sports and Exercise, V30, pS235
  16. Thorsteinsdottir B, 2006, J RENAL NUTR, V16, P341, DOI 10.1053/j.jrn.2006.04.025