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Title: | A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor |
Authors: | FARIA, Andre M.; PEREZ, Ricardo V.; MARCONDES, Jose A. M.; FREIRE, Daniel S.; BLASBALG, Roberto; SOARES JR., Jose; SIMOES, Kleber; HAYASHIDA, Sylvia A. Y.; PEREIRA, Maria A. A. |
Citation: | NATURE REVIEWS ENDOCRINOLOGY, v.7, n.4, p.240-245, 2011 |
Abstract: | Background. A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization. Investigations. Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and (18)F-fluorodeoxyglucose PET imaging. Diagnosis. Virilization secondary to an ovarian Leydig cell tumor. Management. The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - LIM/42 |
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