Clinical outcomes of long-acting injectable risperidone in patients with schizophrenia: six-month follow-up from the Electronic Schizophrenia Treatment Adherence Registry in Latin America
Carregando...
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2011
Título da Revista
ISSN da Revista
Título do Volume
Editora
DOVE MEDICAL PRESS LTD
Autores
Citação
NEUROPSYCHIATRIC DISEASE AND TREATMENT, v.7, p.19-26, 2011
Resumo
Background: Risperidone long-acting injection (RLAI) has been shown to be efficacious, improve compliance, and increase long-term retention rate on therapy. The aim of this work was to determine the effect of RLAI on clinical outcome and hospitalization rate in patients with schizophrenia or schizoaffective disorder enrolled in the electronic Schizophrenia Treatment Adherence Registry in Latin America. Methods: Data were collected at baseline, retrospectively for the 12 months prior to baseline, and prospectively every three months for 24 months. Hospitalization prior to therapy was assessed by a retrospective chart review. Efficacy and functioning were evaluated using Clinical Global Impression of Illness Severity (CGI-S), Personal and Social Performance (PSP), and Global Assessment of Functioning (GAF) scores. Relapse and treatment were also registered. Results: Patients were recruited in Mexico (n = 53), Brazil (n = 11), and Colombia (n = 15). Sixty-five percent (n = 52) were male, and mean age was 32.9 years. Patients were classified as having schizophrenia (n = 73) or schizoaffective disorder (n = 6). The mean dose of RLAI at six months was 34.1 mg (standard deviation = 10.2 mg). The percentage of hospitalized patients before treatment was 28.2% and 5.1% at six months after initiating RLAI (P < 0.001). Significant changes were registered on CGI-S, GAF, and PSP scores. Conclusions: RLAI was associated with an improvement in clinical symptoms and functioning, and a greater reduction in hospitalization.
Palavras-chave
long-acting, risperidone, schizophrenia, schizoaffective disorder, Latin America
Referências
- Annemans L, 2005, PHARMACOECONOMICS, V23, P1
- Robinson D, 1999, ARCH GEN PSYCHIAT, V56, P241, DOI 10.1001/archpsyc.56.3.241
- Taylor DM, 2009, J CLIN PSYCHIAT, V70, P196
- Gilmer TP, 2004, AM J PSYCHIAT, V161, P692, DOI 10.1176/appi.ajp.161.4.692
- WRIGHT EC, 1993, LANCET, V342, P909, DOI 10.1016/0140-6736(93)91951-H
- Moller HJ, 2005, INT CLIN PSYCHOPHARM, V20, P121
- Keefe RSE, 2007, ARCH GEN PSYCHIAT, V64, P633, DOI 10.1001/archpsyc.64.6.633
- Leucht S, 2009, LANCET, V373, P31, DOI [10.1016/S0140-6736(08)61764-X, 10.1016/S01406736(08)61764-X]
- Lacro JP, 2002, J CLIN PSYCHIAT, V63, P892
- Fleischhacker WW, 2003, J CLIN PSYCHIAT, V64, P1250
- Wiersma D, 1998, SCHIZOPHRENIA BULL, V24, P75
- ENDICOTT J, 1976, ARCH GEN PSYCHIAT, V33, P766
- Almond S, 2004, BRIT J PSYCHIAT, V184, P346, DOI 10.1192/bjp.184.4.346
- Valenstein M, 2002, MED CARE, V40, P630, DOI 10.1097/01.MLR.0000021003.43524.64
- Rosa MA, 2005, REV BRAS PSIQUIATR, V27, P178, DOI 10.1590/S1516-44462005000300005
- Goeree R, 2005, CURR MED RES OPIN, V21, P2017, DOI 10.1185/030079905X75087
- Olivares JM, 2009, EUR PSYCHIAT, V24, P287, DOI 10.1016/j.eurpsy.2008.12.002
- Emsley R, 2008, INT CLIN PSYCHOPHARM, V23, P325, DOI 10.1097/YIC.0b013e32830c2042
- Lehman AF, 1998, SCHIZOPHRENIA BULL, V24, P11
- WEIDEN P, 1995, PSYCHIATR SERV, V46, P1049
- Lieberman JA, 1996, J CLIN PSYCHIAT, V57, P5
- LINDENMAYER JP, 1994, J CLIN PSYCHOPHARM, V14, P201
- Swartz MS, 2007, AM J PSYCHIAT, V164, P428, DOI 10.1176/appi.ajp.164.3.428
- DAVIS JM, 1994, DRUGS, V47, P741, DOI 10.2165/00003495-199447050-00004
- Fleischhacker WW, 2003, J CLIN PSYCHIAT, V64, P10
- Peuskens J, 2010, CURR MED RES OPIN, V26, P501, DOI 10.1185/03007990903488670
- Morosini PL, 2000, ACTA PSYCHIAT SCAND, V101, P323, DOI 10.1111/j.1600-0447.2000.tb10933.x
- Robinson DG, 1999, AM J PSYCHIAT, V156, P544
- Dolder CR, 2002, AM J PSYCHIAT, V159, P103, DOI 10.1176/appi.ajp.159.1.103
- Nasrallah HA, 2005, PSYCHIAT SERV, V56, P273, DOI 10.1176/appi.ps.56.3.273
- Emsley R, 2008, J CLIN PSYCHOPHARM, V28, P210, DOI 10.1097/JCP.0b013e318167269d
- Beasley CM, 1996, NEUROPSYCHOPHARMACOL, V14, P111, DOI 10.1016/0893-133X(95)00069-P
- Kane JM, 2003, AM J PSYCHIAT, V160, P1125, DOI 10.1176/appi.ajp.160.6.1125
- Moore A, 2000, BRIT J CLIN PSYCHOL, V39, P287, DOI 10.1348/014466500163293
- Barkic J, 2003, COLLEGIUM ANTROPOL, V27, P111
- BEBBINGTON PE, 1995, INT CLIN PSYCHOPHARM, V9, P41, DOI 10.1097/00004850-199501005-00008
- BLACKWELL B, 1976, BRIT J PSYCHIAT, V129, P513, DOI 10.1192/bjp.129.6.513
- Buckley PF, 2004, SCHIZOPHR RES, V66, P143, DOI 10.1016/j.schres.2003.06.001
- Chue Pierre, 2007, Neuropsychiatr Dis Treat, V3, P13, DOI 10.2147/nedt.2007.3.1.13
- Colonna L, 2000, INT CLIN PSYCHOPHARM, V15, P13, DOI 10.1097/00004850-200015010-00002
- Edwards NC, 2005, PHARMACOECONOMICS, V23, P75
- Fleischhacker WW, 2005, BRIT J PSYCHIAT, V187, P131, DOI 10.1192/bjp.187.2.131
- Haro JM, 2003, ACTA PSYCHIAT SCAN S, V416, P16
- Lambert Tim, 2003, J Psychiatr Pract, V9, P252, DOI 10.1097/00131746-200305000-00011
- LIEBERMAN JA, 1992, SCHIZOPHRENIA BULL, V18, P351
- Lindenmayer Jean-Pierre, 2006, J Psychiatr Pract, V12, P55, DOI 10.1097/00131746-200601000-00009
- Lindenmayer JP, 2004, J CLIN PSYCHIAT, V65, P1084
- Marcus SC, 2008, SCHIZOPHRENIA BULL, V34, P173, DOI 10.1093/schbul/sbm061
- Marder SR, 1998, J CLIN PSYCHIAT, V59, P21
- Marinis T De, 2007, Pharmacopsychiatry, V40, P257, DOI 10.1055/s-2007-992140
- Martin SD, 2003, CURR MED RES OPIN, V19, P298, DOI 10.1185/030079903125001893
- Masand Prakash S, 2006, Curr Clin Pharmacol, V1, P47, DOI 10.2174/157488406775268255
- Masand Prakash S, 2009, Prim Care Companion J Clin Psychiatry, V11, P147, DOI 10.4088/PCC.08r00612
- Nasrallah HA, 2004, J CLIN PSYCHIAT, V65, P531
- Parellada E, 2005, J PSYCHOPHARMACOL, V19, P5, DOI 10.1177/0269881105056513
- Patel MX, 2008, J CLIN PSYCHIAT, V69, P1548
- Pereira S, 1997, ACTA PSYCHIAT SCAND, V95, P464, DOI 10.1111/j.1600-0447.1997.tb10133.x
- Peuskens J, 2002, EUR NEUROPSYCHOPHARM, V12, P305, DOI 10.1016/S0924-977X(02)00031-7
- REMINGTON GJ, 1995, CAN J PSYCHIAT, V40, pS5
- Schmauss M, 2007, INT CLIN PSYCHOPHARM, V22, P85, DOI 10.1097/YIC.0b013e3280119ddb
- SHEPHERD M, 1989, PSYCHOL MED, P1
- Turner M, 2004, INT CLIN PSYCHOPHARM, V19, P241, DOI 10.1097/01.yic.0000133500.92025.20
- Vehof J, 2008, J CLIN PSYCHOPHARM, V28, P625, DOI 10.1097/JCP.0b013e31818a6d10
- Weiden PJ, 2007, J CLIN PSYCHIAT, V68, P12