The utility of p16(INK4a) and Ki-67 to identify high-grade squamous intraepithelial lesion in adolescents and young women
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Citações na Scopus
5
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
Autores
CAVALCANTE, Diane M.
POMPEU, Margarida M. L.
GIRALDO, Paulo C.
ELEUTERIO JR., Jose
Citação
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, v.55, n.3, p.339-342, 2012
Resumo
Background: The repair of the immature squamous epithelium following HPV infection may mimic HSIL in adolescent women. Aim: to study the utility of p16(INK4a) and Ki-67 in diagnosis of cervical squamous lesions in adolescents and young adults. Materials and Methods: In a cross-sectional study, the evaluation of p16(INK4a) and Ki-67 immunohistochemistry was performed on 72 cervical biopsies of adolescents and young adults women diagnosed as negative for malignancy and intraepithelial lesion (NML) (n = 18) or positive for low grade (LSIL) (n = 31) and high grade (HSIL) (n = 23) squamous intraepithelial lesions in two references services in Fortaleza-Brazil. Data was evaluated using Fisher's test and Kappa index. Results: p16(INK4a) was positive in 81% of HSIL, 19% of LSIL and in no NML (P < 0.0001). Ki-67 was positive in 74%, 32% and 5.5% of HSIL, LSIL and NML, respectively. p16(INK4a) and Ki-67 in the diagnosis of HSIL showed high sensitivity and negative predictive value. Kappa index was very good for p16(INK4a) (k = 0.72). Conclusions: In adolescents and young adults p16(INK4a) alone or with Ki-67 represents important tool to reduce mistaken diagnosis of HSIL and to avoid overtreatment.
Palavras-chave
Adolescent, Ki-67, p16, squamous intraepithelial lesions, young adult
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