Influence of maternal and own genotype at tanning dependence-related SNPs on sun exposure in childhood

Imagem de Miniatura
Arquivos
art_KHOUJA_Influence_of_maternal_and_own_genotype_at_tanning_2018.PDF (570.65 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BIOMED CENTRAL LTD
Autores
KHOUJA, Jasmine
LEWIS, Sarah J.
Citação
BMC MEDICAL GENETICS, v.19, article ID 62, 8p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Research suggests there may be a genetic influence on the likelihood of becoming tanning dependent (TD). The way in which mothers regulate their children's sun exposure may be affected by being TD. We investigated the associations between single nucleotide polymorphisms (SNPs) related to being TD and early sun exposure. Methods: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Associations between 17 TD related SNPs in children and then mothers and 10 sun exposure variables in children (assessed via questionnaire at age 8) were analyzed in logistic and ordinal logistic regressions. Analyses were adjusted for principal components of population structure and age (at time of questionnaire response). Models with additional adjustment for maternal or offspring genotypes were also tested. Secondary analyses included adjustment for sex and skin pigmentation. Results: Among ALSPAC children, the rs29132 SNP in the Vesicle-associated membrane protein associated protein A (VAPA) gene was associated with five sun exposure variables whilst the rs650662 SNP in the Opioid Receptor Mu 1 (OPRM1) gene was associated with three. The remaining SNPs did not show associations beyond what was expected by chance. After Bonferroni correction one SNP in the children was associated with an increased likelihood of using sun cream whilst in the sun at 8 years old (rs60050811 in the Spermatogenesis and Centriole Associated 1 (SPATC1) gene, OR per C allele = 1. 34, 95% Cl 1.11-1.62, p = .003). In the mothers, rs650662 in OPRM1 was associated with the use of a lower factor of sun cream in their children, (OR per A allele = 0.89, 95% Cl 0.82-0.96, p = .002) Whilst rs2073478 in the Aldehyde Dehydrogenase 1 Family Member B1 (ALDH1B1) gene was associated with a reduced odds of their child using a sun block or cream with a 4 star rating (OR per T allele = 0.68, 95% Cl 0.53-0.88, p = .003). Similar but weaker associations were observed for the main findings in the secondary analyses. Conclusions: We found weak evidence to suggest that genes previously associated with TD are associated with sun exposure in children of European ancestry from southwest England.
Palavras-chave
Tanning dependenceMaternal, SNPs/single nucleotide polymorphisms, Genotypes, ALSPAC
URI
https://observatorio.fm.usp.br/handle/OPI/27198
Referências
  1. Bonilla C, 2016, INT J CANCER, V139, P1520, DOI 10.1002/ijc.30206
  2. Bonilla C, 2014, BMC PUBLIC HEALTH, V14, DOI 10.1186/1471-2458-14-597
  3. Boyd A, 2013, INT J EPIDEMIOL, V42, P111, DOI 10.1093/ije/dys064
  4. Boyle R, 2010, BRIT J DERMATOL, V163, P1269, DOI 10.1111/j.1365-2133.2010.09977.x
  5. Cartmel B, 2014, EXP DERMATOL, V23, P757, DOI 10.1111/exd.12503
  6. Farhat Elizabeth K, 2012, Arch Dermatol, V148, P1182, DOI 10.1001/archdermatol.2012.956
  7. Fatiha El Ghissassi, 2009, LANCET ONCOL, V10, P751
  8. Flores KG, 2013, EXP DERMATOL, V22, P576, DOI 10.1111/exd.12200
  9. Fraser A, 2013, INT J EPIDEMIOL, V42, P97, DOI 10.1093/ije/dys066
  10. Harrington CR, 2011, CLIN EXP DERMATOL, V36, P33, DOI 10.1111/j.1365-2230.2010.03882.x
  11. Heckman CJ, 2014, J EUR ACAD DERMATOL, V28, P1179, DOI 10.1111/jdv.12243
  12. Heckman CJ, 2008, AM J HEALTH BEHAV, V32, P451, DOI 10.5555/ajhb.2008.32.5.451
  13. Kaur M, 2006, J AM ACAD DERMATOL, V54, P709, DOI 10.1016/j.jaad.2005.11.1059
  14. Knight JM, 2002, ARCH DERMATOL, V138, P1311, DOI 10.1001/archderm.138.10.1311
  15. Le Clair Marie Z, 2016, Prev Med Rep, V3, P139, DOI 10.1016/j.pmedr.2015.11.016
  16. Li WQ, 2017, BRIT J DERMATOL, V176, P526, DOI 10.1111/bjd.14847
  17. Mogensen Mette, 2010, Cancer Manag Res, V2, P277, DOI 10.2147/CMR.S7403
  18. Nolan BV, 2009, PHOTODERMATOL PHOTO, V25, P12, DOI 10.1111/j.1600-0781.2009.00392.x
  19. Quillen EE, 2012, HUM GENET, V131, P1073, DOI 10.1007/s00439-011-1135-1
  20. Richmond RC, 2017, PLOS MED, V14, DOI 10.1371/journal.pmed.1002221
  21. Sterne JAC, 2001, BRIT MED J, V322, P226, DOI 10.1136/bmj.322.7280.226
  22. Warthan MM, 2005, ARCH DERMATOL, V141, P963, DOI 10.1001/archderm.141.8.963
  23. Zhang HP, 2006, HUM MOL GENET, V15, P807, DOI 10.1093/hmg/ddl024

Coleções
Artigos e Materiais de Revistas Científicas - LIM/38