The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

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art_RICKETTS_The_Cancer_Genome_Atlas_Comprehensive_Molecular_Characterization_of_2018.PDF (6.55 MB)
Citações na Scopus
515
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CELL PRESS
Autores
RICKETTS, Christopher J.
CUBAS, Aguirre A. de
FAN, Huihui
SMITH, Christof C.
LANG, Martin
REZNIK, Ed
BOWLBY, Reanne
GIBB, Ewan A.
AKBANI, Rehan
BEROUKHIM, Rameen
Citação
CELL REPORTS, v.23, n.1, p.313-326.e5, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Renal cell carcinoma(RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/30121
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/14
Artigos e Materiais de Revistas Científicas - ODS/03