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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | COUTINHO, Mariana Nogueira | |
dc.contributor.author | CARVALHO, Aluizio Barbosa | |
dc.contributor.author | DALBONI, Maria Aparecida | |
dc.contributor.author | MOURO, Margaret Gori | |
dc.contributor.author | HIGA, Elisa Mieko Suemitsu | |
dc.contributor.author | COSTA-HONG, Valeria | |
dc.contributor.author | BORTOLOTTO, Luiz Aparecido | |
dc.contributor.author | FIGUEIREDO, Rejane Augusta de Oliveira | |
dc.contributor.author | CANZIANI, Maria Eugenia Fernandes | |
dc.date.accessioned | 2019-01-17T13:40:07Z | - |
dc.date.available | 2019-01-17T13:40:07Z | - |
dc.date.issued | 2018 | |
dc.identifier.citation | JOURNAL OF DIABETES RESEARCH, article ID 7926473, 8p, 2018 | |
dc.identifier.issn | 2314-6745 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/30245 | - |
dc.description.abstract | Background. Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients. Methods. We measured endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1 alpha), serum and urinary nitric oxide (NO), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in 37 CKD patients with DM (CKD-DM group) and in 37 without DM (CKD group). Results. CKD-DM group had a higher prevalence of obesity (P < 0 01), previous myocardial infarction (P = 0 02), myocardial revascularization (P = 0 04), and a trend for more peripheral artery disease (P = 0 07). Additionally, CKD-DM group had higher EPC (P = 0 001) and PWV (P < 0 001) values. On the other hand, no difference in SDF-1 alpha and serum or urinary NO and FMD was observed between the groups. Conclusions. Endothelial dysfunction is frequent in CKD patients, and an additive effect of diabetes cannot be implicated, suggesting the predominant role of uremia in this condition. | eng |
dc.language.iso | eng | |
dc.publisher | HINDAWI LTD | eng |
dc.relation.ispartof | Journal of Diabetes Research | |
dc.rights | openAccess | eng |
dc.subject.other | progenitor cells | eng |
dc.subject.other | nitric-oxide | eng |
dc.subject.other | cardiovascular outcomes | eng |
dc.subject.other | mediated vasodilation | eng |
dc.subject.other | dysfunction | eng |
dc.subject.other | mortality | eng |
dc.subject.other | number | eng |
dc.subject.other | pathogenesis | eng |
dc.subject.other | imbalance | eng |
dc.subject.other | mellitus | eng |
dc.title | There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients | eng |
dc.type | article | eng |
dc.rights.holder | Copyright HINDAWI LTD | eng |
dc.identifier.doi | 10.1155/2018/7926473 | |
dc.identifier.pmid | 30596103 | |
dc.subject.wos | Endocrinology & Metabolism | eng |
dc.subject.wos | Medicine, Research & Experimental | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | COUTINHO, Mariana Nogueira:Univ Fed Sao Paulo, Sao Paulo, Brazil | |
hcfmusp.author.external | CARVALHO, Aluizio Barbosa:Univ Fed Sao Paulo, Sao Paulo, Brazil | |
hcfmusp.author.external | DALBONI, Maria Aparecida:Univ Fed Sao Paulo, Sao Paulo, Brazil | |
hcfmusp.author.external | MOURO, Margaret Gori:Univ Fed Sao Paulo, Sao Paulo, Brazil | |
hcfmusp.author.external | HIGA, Elisa Mieko Suemitsu:Univ Fed Sao Paulo, Sao Paulo, Brazil | |
hcfmusp.author.external | FIGUEIREDO, Rejane Augusta de Oliveira:Folkalsan Res Ctr, Helsinki, Finland | |
hcfmusp.author.external | CANZIANI, Maria Eugenia Fernandes:Univ Fed Sao Paulo, Sao Paulo, Brazil | |
hcfmusp.description.articlenumber | 7926473 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000452999900001 | |
hcfmusp.origem.id | 2-s2.0-85059285620 | |
hcfmusp.publisher.city | LONDON | eng |
hcfmusp.publisher.country | ENGLAND | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 2314-6753 | |
hcfmusp.citation.scopus | 6 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_COUTINHO_There_Is_No_Impact_of_Diabetes_on_the_2018.PDF | publishedVersion (English) | 2.74 MB | Adobe PDF | View/Open |
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