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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCABRAL, Norberto Luiz
dc.contributor.authorNAGEL, Vivian
dc.contributor.authorCONFORTO, Adriana B.
dc.contributor.authorMAGALHAES, Pedro S. C.
dc.contributor.authorVENANCIO, Vanessa G.
dc.contributor.authorSAFANELLI, Juliana
dc.contributor.authorIBIAPINA, Felipe
dc.contributor.authorMAZIN, Suleimy
dc.contributor.authorFRANCA, Paulo
dc.contributor.authorLIBERATO, Rafaela M.
dc.contributor.authorLONGO, Alexandre
dc.contributor.authorZETOLA, Viviane F.
dc.identifier.citationINTERNATIONAL JOURNAL OF STROKE, v.14, n.5, p.491-499, 2019
dc.description.abstractBackground Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis of ischemic stroke subtypes in Joinville, Brazil. Methods All first-ever ischemic strokes that occurred in Joinville in 2010 were followed-up for five years. Results We included 334 ischemic stroke patients. Over five years, 156 died, 51 had a recurrent stroke, and 128 were free of recurrent stroke. The overall cumulative risk of death was 17% (95% CI, 13% to 22%) at 30 days and 47% (95% CI, 41% to 52%) after five years. Undetermined with incomplete investigation ischemic stroke had a significantly worse survival probability (beta -4.91; 95% CI, -6.31 to -3.50; p < 0.001), followed by cardioembolic ischemic stroke (beta -3.07; 95% CI, -4.32 to -1.83; p < 0.001) and large artery disease ischemic stroke (beta -1.95; 95% CI, -3.30 to -0.60; p = 0.005). The survival probability of undetermined with negative investigation or cryptogenic ischemic stroke did not differ significantly from small artery disease ischemic stroke (beta -1.022; 95% CI, -3.37 to -1.43; p = 0.414). The five-year mortality for small artery disease ischemic stroke was 30% (95% CI, 22% to 39%) and 47% (95% CI, 35% to 60%) for large artery ischemic stroke. The risk of stroke recurrence was 2% in the first year and 5% in the second year. The proportion of disability among survivors in the first month ranged from 8% (95% CI, 3-15) for small artery disease ischemic stroke to 40% (95% CI, 30-52) for cardioembolic ischemic stroke patients. Conclusions Cardioembolic and undetermined with incomplete investigation ischemic stroke sub-types have a poor long-term prognosis. An alarming finding was that our patients with both small and large artery ischemic stroke had higher five-year mortality rates compared with subjects from high-income countries.eng
dc.relation.ispartofInternational Journal of Stroke
dc.subjectIschemic stroke subtypeeng
dc.subjectstroke prognosiseng
dc.subject.othermodified rankin scaleeng
dc.subject.otherlong-term survivaleng
dc.titleHigh five-year mortality rates of ischemic stroke subtypes: A prospective cohort study in Brazileng
dc.rights.holderCopyright SAGE PUBLICATIONS LTDeng
dc.subject.wosClinical Neurologyeng
dc.subject.wosPeripheral Vascular Diseaseeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng, Norberto Luiz:Joinville Stroke Registry, Joinville, Brazil; Univ Regiao Joinville, Paulo Malschitzki 10, BR-89201700 Joinville, SC, Brazil, Vivian:Joinville Stroke Registry, Joinville, Brazil, Pedro S. C.:Univ Regiao Joinville, Paulo Malschitzki 10, BR-89201700 Joinville, SC, Brazil, Vanessa G.:Univ Regiao Joinville, Paulo Malschitzki 10, BR-89201700 Joinville, SC, Brazil, Juliana:Univ Regiao Joinville, Paulo Malschitzki 10, BR-89201700 Joinville, SC, Brazil, Felipe:Hosp Municipal Sao Jose, Joinville, Brazil, Suleimy:Univ Sao Paulo, Dept Med, Ribeirao Preto, SP, Brazil, Paulo:Joinville Stroke Registry, Joinville, Brazil, Rafaela M.:Univ Regiao Joinville, Paulo Malschitzki 10, BR-89201700 Joinville, SC, Brazil, Alexandre:Hosp Municipal Sao Jose, Joinville, Brazil, Viviane F.:Univ Fed Parana, Neurol Dept, Curitiba, Parana, Brazil
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Instituto Central - HC/ICHC

Artigos e Materiais de Revistas Científicas - LIM/15
LIM/15 - Laboratório de Investigação em Neurologia

Artigos e Materiais de Revistas Científicas - ODS/03
ODS/03 - Saúde e bem-estar

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