Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

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art_FAVRE_Widespread_white_matter_microstructural_abnormalities_in_bipolar_disorder_2019.PDF (1.22 MB)
Citações na Scopus
125
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
NATURE PUBLISHING GROUP
Autores
FAVRE, Pauline
PAULING, Melissa
STOUT, Jacques
HOZER, Franz
SARRAZIN, Samuel
ABE, Christoph
ALDA, Martin
ALLOZA, Clara
ALONSO-LANA, Silvia
ANDREASSEN, Ole A.
Citação
NEUROPSYCHOPHARMACOLOGY, v.44, n.13, p.2285-2293, 2019
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R-2 = 0.041, P-corr < 0.001) and cingulum (right: R-2 = 0.041, left: R-2 = 0.040, P-corr < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/34533
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21