High Serum Netrin-1 and IL-1 beta in Elderly Females with ACS: Worse Prognosis in 2-years Follow-up

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art_LEOCADIO_High_Serum_Netrin1_and_IL1_beta_in_Elderly_2020.PDF (405.2 KB)
Citações na Scopus
7
Tipo de produção
article
Data de publicação
2020
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ARQUIVOS BRASILEIROS CARDIOLOGIA
Autores
LEOCADIO, Paola
MENTA, Penelope
DIAS, Melissa
FRAGA, Julia
ALVAREZ-LEITE, Jacqueline
Citação
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.114, n.3, p.507-514, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Several markers have been evaluated for a potential impact on clinical decisions or mortality prediction in acute coronary syndrome (ACS), including Netrin-1 and IL-1 beta that have been associated with cardiovascular disease. Objective: Our study examined the prognostic value of Netrin-1 and IL-1 beta in patients with ACS (2-year follow-up). Methods: We evaluate Netrin-1, IL-1 beta and other risk factors in the serum sample of 803 patients. Kaplan-Meier curves and Cox regression were used for the analysis of all-cause mortality, cardiovascular mortality, and a combined outcome of fatal myocardial infarction (MI) or new non-fatal MI, considering p-value < 0.05. Results: There were 115 deaths from all causes, 78 deaths due to cardiovascular causes and 67 events in combined outcomes. Netrin-1 levels above the median (>44.8 pg/mL) were associated with a worse prognosis (all-cause mortality and cardiovascular mortality) in elderly females, even after model adjustment (HR: 2.08, p = 0.038 and HR: 2.68, p = 0.036). IL-1 beta levels above the median (>13.4 pg/mL) in elderly females were associated with increased risk of all outcomes after adjustment (all-cause mortality - HR: 2.03, p = 0.031; cardiovascular mortality - HR: 3.01, p = 0.013; fatal MI or new non-fatal MI - HR: 3.05, p = 0.029). For males, no associations were observed between Netrin-1 or IL-1 beta and outcomes. Conclusion: High serum levels of Netrin-1 and IL-1 beta showed significant association with worse prognosis in elderly females. They may be useful as prognostic indicators in ACS.
Palavras-chave
Acute Coronary Syndrome/physiopathology, Netrin-1, Interleukin-1 beta, Atrial Remodeling, Hypertension, Diabetes Mellitus, Dyslipidemias, Stroke, Aged, Women
URI
https://observatorio.fm.usp.br/handle/OPI/35832
Referências
  1. Basra SS, 2016, HEART FAIL CLIN, V12, P31, DOI 10.1016/j.hfc.2015.08.004
  2. Benjamin EJ, 2017, CIRCULATION, V135, pE146, DOI 10.1161/CIR.0000000000000485
  3. Bouhidel JO, 2015, BBA-MOL BASIS DIS, V1852, P277, DOI 10.1016/j.bbadis.2014.06.005
  4. Bourgeois MM, 2010, BIOMARK MED, V4, P843, DOI 10.2217/BMM.10.102
  5. Cirulli V, 2007, NAT REV MOL CELL BIO, V8, P296, DOI 10.1038/nrm2142
  6. Correia LCL, 2010, CLIN CHIM ACTA, V411, P540, DOI 10.1016/j.cca.2010.01.011
  7. Dewald O, 2004, AM J PATHOL, V164, P665, DOI 10.1016/S0002-9440(10)63154-9
  8. Ertl G, 2005, CARDIOVASC RES, V66, P22, DOI 10.1016/j.cardiores.2005.01.011
  9. Frangogiannis NG, 2008, PHARMACOL RES, V58, P88, DOI 10.1016/j.phrs.2008.06.007
  10. Frantz S, 2009, CARDIOVASC RES, V81, P474, DOI 10.1093/cvr/cvn292
  11. FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
  12. Goulart AC, 2013, CLINICS, V68, P431, DOI 10.6061/clinics/2013(03)RC02
  13. Haroon J, 2015, CYTOKINE, V71, P54, DOI 10.1016/j.cyto.2014.08.008
  14. Harter PN, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0092311
  15. Kassebaum NJ, 2016, LANCET, V388, P1603, DOI 10.1016/S0140-6736(16)31460-X
  16. Kilic T, 2006, HEART, V92, P1041, DOI 10.1136/hrt.2005.080382
  17. Layne K, 2015, CARDIOVASC RES, V107, P410, DOI 10.1093/cvr/cvv201
  18. Libby P, 2014, CIRC RES, V114, P1867, DOI 10.1161/CIRCRESAHA.114.302699
  19. Link BC, 2007, ANN SURG ONCOL, V14, P2591, DOI 10.1245/s10434-007-9469-6
  20. Lyngdoh T, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0019901
  21. Mao XG, 2014, INFLAMMATION, V37, P573, DOI 10.1007/s10753-013-9771-3
  22. Marques-Vidal P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021002
  23. Orn S, 2012, J INTERN MED, V272, P267, DOI 10.1111/j.1365-2796.2012.02517.x
  24. Ozeren A, 2003, MEDIAT INFLAMM, V12, P361, DOI 10.1080/09629350310001633360
  25. Prabhu SD, 2016, CIRC RES, V119, P91, DOI 10.1161/CIRCRESAHA.116.303577
  26. Ramesh G, 2011, BIOMARKERS, V16, P172, DOI 10.3109/1354750X.2010.541564
  27. Ramesh G, 2010, CLIN J AM SOC NEPHRO, V5, P395, DOI 10.2215/CJN.05140709
  28. Ramkhelawon B, 2013, ARTERIOSCL THROM VAS, V33, P1180, DOI 10.1161/ATVBAHA.112.301008
  29. Reeves WB, 2008, AM J PHYSIOL-RENAL, V294, pF731, DOI 10.1152/ajprenal.00507.2007
  30. Ribeiro ALP, 2016, CIRCULATION, V133, P422, DOI 10.1161/CIRCULATIONAHA.114.008727
  31. Ridker PM, 2017, NEW ENGL J MED, V377, P1119, DOI 10.1056/NEJMoa1707914
  32. Santos IS, 2015, ARQ BRAS CARDIOL, V105, P53, DOI 10.5935/abc.20150044
  33. van Gils JM, 2013, ARTERIOSCL THROM VAS, V33, P911, DOI 10.1161/ATVBAHA.112.301155
  34. van Gils JM, 2012, NAT IMMUNOL, V13, P136, DOI 10.1038/ni.2205
  35. Yim J, 2018, FRONT ENDOCRINOL, V9, DOI 10.3389/fendo.2018.00691
  36. Zhang J, 2010, J MOL CELL CARDIOL, V48, P1060, DOI 10.1016/j.yjmcc.2009.11.020

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/20
Artigos e Materiais de Revistas Científicas - LIM/51
Artigos e Materiais de Revistas Científicas - ODS/03