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https://observatorio.fm.usp.br/handle/OPI/36157
Title: | Adjuvant chemotherapy in biliary tract cancer patients: A systematic review and meta-analysis of randomized controlled trials |
Authors: | CAPARICA, Rafael; BRUZZONE, Marco; HACHEM, Georges El; CEPPI, Marcello; LAMBERTINI, Matteo; GLASBERG, Joao; AZAMBUJA, Evandro de; LAETHEM, Jean-Luc Van; HENDLISZ, Alain |
Citation: | CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, v.149, article ID UNSP 102940, 9p, 2020 |
Abstract: | Background: The role of adjuvant chemotherapy in biliary tract cancer is controversial. We performed a systematic review and meta-analysis to assess the effect of adjuvant chemotherapy in biliary tract cancer patients. Methods: A literature search was performed to identify randomized controlled trials (RCTs) comparing adjuvant chemotherapy versus observation, and a pooled analysis was conducted using the random-effect model. Results: Three RCTs (N = 866) were included. No difference was observed between chemotherapy and observation in terms of OS (HR 0.91; 95 %CI, 0.75-1.09; p = 0.295), whereas a significant improvement in RFS was shown (HR 0.83; 95 %CI, 0.69-0.99; p = 0.040). No subgroup that benefited most from adjuvant chemotherapy was identified, although a trend was observed in N+ patients (HR 0.83; 95 %CI, 0.65-1.08; p = 0.165). Discussion: Adjuvant chemotherapy yields a significant RFS benefit in biliary tract cancer patients and should be considered for those who are able to tolerate additional treatment after surgery. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICESP Artigos e Materiais de Revistas Científicas - ODS/03 |
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