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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | SICILIANO, Rinaldo F. | |
dc.contributor.author | GUALANDRO, Danielle M. | |
dc.contributor.author | BITTENCOURT, Marcio Sommer | |
dc.contributor.author | PAIXAO, Milena | |
dc.contributor.author | MARCONDES-BRAGA, Fabiana | |
dc.contributor.author | SOEIRO, Alexandre de Matos | |
dc.contributor.author | STRUNZ, Celia | |
dc.contributor.author | PACANARO, Ana Paula | |
dc.contributor.author | PUELACHER, Christian | |
dc.contributor.author | TARASOUTCHI, Flavio | |
dc.contributor.author | SOMMA, Salvatore Di | |
dc.contributor.author | CARAMELLI, Bruno | |
dc.contributor.author | OLIVEIRA JUNIOR, Mucio Tavares de | |
dc.contributor.author | MANSUR, Alfredo Jose | |
dc.contributor.author | MUELLER, Christian | |
dc.contributor.author | BARRETTO, Antonio Carlos Pereira | |
dc.contributor.author | STRABELLI, Tania Mara Varejao | |
dc.date.accessioned | 2020-10-15T14:32:00Z | - |
dc.date.available | 2020-10-15T14:32:00Z | - |
dc.date.issued | 2020 | |
dc.identifier.citation | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.96, p.25-30, 2020 | |
dc.identifier.issn | 1201-9712 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/37692 | - |
dc.description.abstract | Background: Evidence regarding biomarkers for risk prediction in patients with infective endocarditis (IE) is limited. We aimed to investigate the value of a panel of biomarkers for the prediction of in-hospital mortality in patients with IE. Methods: Between 2016 and 2018, consecutive IE patients admitted to the emergency department were prospectively included. Blood concentrations of nine biomarkers were measured at admission (D0) and on the seventh day (D7) of antibiotic therapy: C-reactive protein (CRP), sensitive troponin I (s-cTnI), procalcitonin, B-type natriuretic peptide (BNP), neutrophil gelatinase-associated lipocalin (NGAL), interleukin 6 (IL6), tumor necrosis fator a (TNF-a), proadrenomedullin, alpha-1-acid glycoprotein, and galectin 3. The primary endpoint was in-hospital mortality. Results: Among 97 patients, 56% underwent cardiac surgery, and in-hospital mortality was 27%. At admission, six biomarkers were independent predictors of in-hospital mortality: s-cTnI (OR 3.4; 95%CI 1.8-6.4; P < 0.001), BNP (OR 2.7; 95%CI 1.4-5.1; P = 0.002), IL-6 (OR 2.06; 95%CI 1.3-3.7; P = 0.019), procalcitonin (OR 1.9; 95%CI 1.1-3.2; P = 0.018), TNF-alpha (OR 1.8; 95%CI 1.1-2.9; P = 0.019), and CRP (OR 1.8; 95%CI 1.0-3.3; P = 0.037). At admission, S-cTnI provided the highest accuracy for predicting mortality (area under the ROC curve: s-cTnI 0.812, BNP 0.727, IL-6 0.734, procalcitonin 0.684, TNF-alpha 0.675, CRP 0.670). After 7 days of antibiotic therapy, BNP and inflammatory biomarkers improved their performance (s-cTnI 0.814, BNP 0.823, IL-6 0.695, procalcitonin 0.802, TNF-alpha 0.554, CRP 0.759). Conclusion: S-cTnI concentration measured at admission had the highest accuracy for mortality prediction in patients with IE. (C) 2020 The Authors. | eng |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil [FAPESP]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [4174/15/001] | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCI LTD | eng |
dc.relation.ispartof | International Journal of Infectious Diseases | |
dc.rights | openAccess | eng |
dc.subject | Infective endocarditis | eng |
dc.subject | Biomarkers | eng |
dc.subject | Prognosis | eng |
dc.subject | Mortality | eng |
dc.title | Biomarkers for prediction of mortality in left-sided infective endocarditis | eng |
dc.type | article | eng |
dc.rights.holder | Copyright ELSEVIER SCI LTD | eng |
dc.identifier.doi | 10.1016/j.ijid.2020.03.009 | |
dc.identifier.pmid | 32169690 | |
dc.subject.wos | Infectious Diseases | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | PUELACHER, Christian:GREAT Global Res Acute Condit Team Network, Sao Paulo, Brazil; Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel CRIB, Basel, Switzerland; Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland | |
hcfmusp.author.external | SOMMA, Salvatore Di:GREAT Global Res Acute Condit Team Network, Sao Paulo, Brazil; Univ Rome Sapienza, Dept Med Surg Sci & Translat Med, Rome, Italy | |
hcfmusp.author.external | MUELLER, Christian:Univ Sao Paulo, Med Sch, Heart Inst InCor, Sao Paulo, Brazil; Univ Basel, Univ Hosp Basel, Cardiovasc Res Inst Basel CRIB, Basel, Switzerland; Univ Basel, Univ Hosp Basel, Dept Cardiol, Basel, Switzerland | |
hcfmusp.description.beginpage | 25 | |
hcfmusp.description.endpage | 30 | |
hcfmusp.description.volume | 96 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000553435700002 | |
hcfmusp.origem.id | 2-s2.0-85085109861 | |
hcfmusp.publisher.city | OXFORD | eng |
hcfmusp.publisher.country | ENGLAND | eng |
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dc.description.index | MEDLINE | eng |
dc.identifier.eissn | 1878-3511 | |
hcfmusp.citation.scopus | 12 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/47 Artigos e Materiais de Revistas Científicas - LIM/64 Artigos e Materiais de Revistas Científicas - ODS/03 |
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