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DC Field | Value | Language |
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dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | SILVA, Pedro Gabriel Melo de Barros e | |
dc.contributor.author | BERWANGER, Otavio | |
dc.contributor.author | PRECOMA, Dalton Bertolim | |
dc.contributor.author | CAVALCANTE, Margaret Assad | |
dc.contributor.author | VILELA-MARTIN, Jose Fernando | |
dc.contributor.author | FIGUEIREDO, Estevao Lanna | |
dc.contributor.author | LOPES, Renato Delascio | |
dc.contributor.author | BODANESE, Luiz Carlos | |
dc.contributor.author | GUIMARAES, Jorge Ilha | |
dc.contributor.author | ANDRADE, Jadelson Pinheiro de | |
dc.contributor.author | PAOLA, Angelo Amato Vincenzo de | |
dc.contributor.author | MALACHIAS, Marcus Vinicius Bolivar | |
dc.contributor.author | MATTOS, Luiz Alberto Piva e | |
dc.contributor.author | BACAL, Fernando | |
dc.contributor.author | DUTRA, Oscar Pereira | |
dc.date.accessioned | 2021-04-15T20:04:31Z | - |
dc.date.available | 2021-04-15T20:04:31Z | - |
dc.date.issued | 2021 | |
dc.identifier.citation | ARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.116, n.1, p.108-116, 2021 | |
dc.identifier.issn | 0066-782X | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/40128 | - |
dc.description.abstract | Background: In clinical practice, there is evidence of failure to prescribe evidence-based therapies for patients at high cardiovascular risk. However, in Brazil, data on 1-year outcomes of these patients remain insufficient. Objectives: To describe the use of evidence-based therapies and the occurrence of major cardiovascular outcomes and their major predictors in a 12-month follow-up of a Brazilian multicenter registry of patients at high cardiovascular risk. Methods: This prospective observational study documented the outpatient clinical practice of managing patients over 45 years of age and of high cardiovascular risk in both primary and secondary prevention. Patients were followed-up for 1 year, and the prescription of evidence-based therapies and the occurrence of major cardiovascular events (myocardial infarction, stroke, cardiac arrest, and cardiovascular death) were assessed. P-values < 0.05 were considered statistically significant. Results: From July 2010 to August 2014, a total of 5076 individuals were enrolled in 48 centers, 91% of the 4975 eligible patients were followed-up in cardiology centers, and 68.6% were in secondary prevention. At 1 year, the concomitant use of antiplatelet agents, statins, and angiotensin-converting enzyme inhibitors reduced from 28.3% to 24.2% (p < 0.001). Major cardiovascular event rate was 5.46%, and the identified predictors were age, patients in secondary prevention, and diabetic nephropathy. Conclusions: In this large national registry of patients at high cardiovascular risk, risk predictors similar to those of international registries were identified, but medical prescription adherence to evidence-based therapies was inferior and significantly worsened at 1 year. | eng |
dc.description.abstract | Resumo Fundamento: Na prática clínica, há evidências de falhas na prescrição de terapias baseadas em evidências para pacientes de alto risco cardiovascular. Entretanto, no Brasil, ainda são insuficientes os dados sobre a evolução ao longo de 1 ano desses pacientes.Objetivos: Descrição no acompanhamento de 12 meses da utilização de terapias baseadas em evidência e da ocorrência de desfechos cardiovasculares maiores e seus principais preditores em um registro brasileiro multicêntrico de pacientes de alto risco cardiovascular.Métodos: Estudo observacional prospectivo que documentou a prática clínica ambulatorial de indivíduos acima de 45 anos e de alto risco cardiovascular tanto em prevenção primária como secundária. Os pacientes foram seguidos por 1 ano e avaliou-se a prescrição de terapias baseadas em evidência e a ocorrência de eventos cardiovasculares maiores (infarto agudo do miocárdio [IAM], acidente vascular cerebral [AVC], parada cardíaca e mortalidade por causa cardiovascular). Valores de p < 0,05 foram considerados estatisticamente significantes.Resultados: De julho de 2010 até agosto de 2014, 5.076 indivíduos foram incluídos em 48 centros, sendo 91% dos 4.975 pacientes elegíveis acompanhados em centros de cardiologia e 68,6% em prevenção secundária. Em 1 ano, o uso concomitante de antiplaquetários, estatinas e inibidores da enzima conversora de angiotensina (IECA) reduziu de 28,3% para 24,2% (valor de p < 0,001). A taxa de eventos cardiovasculares maiores foi de 5,46%, e os preditores identificados foram: idade, pacientes em prevenção secundária e nefropatia diabética.Conclusões: Neste grande registro nacional de pacientes de alto risco cardiovascular, foram identificados preditores de risco semelhantes aos registros internacionais, porém a adesão da prescrição médica a terapias baseadas em evidência esteve abaixo dos dados da literatura internacional e apresentou piora significativa em 1 ano. | |
dc.description.sponsorship | Sociedade Brasileira de Cardiologia | |
dc.language.iso | eng | |
dc.publisher | ARQUIVOS BRASILEIROS CARDIOLOGIA | eng |
dc.relation.ispartof | Arquivos Brasileiros de Cardiologia | |
dc.rights | openAccess | eng |
dc.subject | Cardiovascular Diseases | eng |
dc.subject | Risk Factors | eng |
dc.subject | Prescription Drugs | eng |
dc.subject | Multicenter Studies as Topic | eng |
dc.subject | Medical Record Linkage | eng |
dc.subject | Doenças Cardiovasculares | |
dc.subject | Fatores de Risco | |
dc.subject | Medicamentos Sob Prescrição | |
dc.subject | Estudos Multicêntricos como Assunto | |
dc.subject | Registro Médico Coordenado. | |
dc.subject.other | disease | eng |
dc.subject.other | contemporary | eng |
dc.subject.other | management | eng |
dc.subject.other | mortality | eng |
dc.title | Evaluation of 1-Year Follow-up of Patients Included in the Registry of Clinical Practice in Patients at High Cardiovascular Risk (REACT) | eng |
dc.title.alternative | Avaliação do Seguimento de 1 Ano dos Pacientes Incluídos no Registro da Prática Clínica em Pacientes de Alto Risco Cardiovascular (REACT) | |
dc.type | article | eng |
dc.rights.holder | Copyright ARQUIVOS BRASILEIROS CARDIOLOGIA | eng |
dc.identifier.doi | 10.36660/abc.20190885 | |
dc.identifier.pmid | 33331461 | |
dc.subject.wos | Cardiac & Cardiovascular Systems | eng |
dc.type.category | original article | eng |
dc.type.version | publishedVersion | eng |
hcfmusp.author.external | SILVA, Pedro Gabriel Melo de Barros e:Inst Pesquisa HCor, Sao Paulo, SP, Brazil; Hosp Samaritano Paulista, Sao Paulo, SP, Brazil | |
hcfmusp.author.external | BERWANGER, Otavio:Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil | |
hcfmusp.author.external | PRECOMA, Dalton Bertolim:Pontificia Univ Catolica Parana, Escola Med, Curitiba, Parana, Brazil; Soc Hosp Angelina Caron, Cardiol, Campina Grande Do Sul, PR, Brazil | |
hcfmusp.author.external | CAVALCANTE, Margaret Assad:Univ Oeste Paulista Unoeste, Presidente Prudente, SP, Brazil; Hosp Reg Presidente Prudente, Presidente Prudente, SP, Brazil | |
hcfmusp.author.external | VILELA-MARTIN, Jose Fernando:Fac Med Sao Jose do Rio Preto FAMERP, Sao Jose Do Rio Preto, SP, Brazil; Soc Brasileira Cardiol, Dept Hipertensao Arterial, Rio De Janeiro, RJ, Brazil | |
hcfmusp.author.external | FIGUEIREDO, Estevao Lanna:Hosp Lifectr, Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | LOPES, Renato Delascio:Duke Univ Hosp, Durham, NC USA | |
hcfmusp.author.external | BODANESE, Luiz Carlos:Hosp Sao Lucas, Porto Alegre, RS, Brazil | |
hcfmusp.author.external | GUIMARAES, Jorge Ilha:Soc Brasileira Cardiol, Rio De Janeiro, RJ, Brazil | |
hcfmusp.author.external | ANDRADE, Jadelson Pinheiro de:Hosp Bahia, Salvador, BA, Brazil | |
hcfmusp.author.external | PAOLA, Angelo Amato Vincenzo de:Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil | |
hcfmusp.author.external | MALACHIAS, Marcus Vinicius Bolivar:Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil; Inst Hipertensao Arterial, Diretoria Clin, Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | MATTOS, Luiz Alberto Piva e:Rede Dor Hosp, Sao Paulo, SP, Brazil | |
hcfmusp.author.external | DUTRA, Oscar Pereira:Fundacao Univ Cardiol Rio Grande do Sul, Inst Cardiol, Porto Alegre, RS, Brazil | |
hcfmusp.description.beginpage | 108 | |
hcfmusp.description.endpage | 116 | |
hcfmusp.description.issue | 1 | |
hcfmusp.description.volume | 116 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.id | WOS:000615367300020 | |
hcfmusp.origem.id | 2-s2.0-85100777444 | |
hcfmusp.origem.id | SCIELO:S0066-782X2021000100108 | |
hcfmusp.publisher.city | RIO DE JANEIRO | eng |
hcfmusp.publisher.country | BRAZIL | eng |
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dc.description.index | MEDLINE | eng |
hcfmusp.citation.scopus | 5 | - |
hcfmusp.scopus.lastupdate | 2024-03-29 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/11 Artigos e Materiais de Revistas Científicas - ODS/03 |
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art_SILVA_Evaluation_of_1Year_Followup_of_Patients_Included_in_2021_eng.PDF | publishedVersion (English) | 481.25 kB | Adobe PDF | View/Open |
art_SILVA_Evaluation_of_1Year_Followup_of_Patients_Included_in_2021_por.PDF | publishedVersion (Portuguese) | 507.42 kB | Adobe PDF | View/Open |
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