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https://observatorio.fm.usp.br/handle/OPI/41036
Title: | Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice |
Authors: | YARIWAKE, Victor Yuji; TORRES, Janaina Iannicelli; SANTOS, Amandda Rakell Peixoto dos; FREITAS, Sarah Cristina Ferreira; ANGELIS, Katia De; FARHAT, Sylvia Costa Lima; CAMARA, Niels Olsen Saraiva; VERAS, Mariana Matera |
Citation: | PARTICLE AND FIBRE TOXICOLOGY, v.18, n.1, article ID 15, 16p, 2021 |
Abstract: | Background Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 mu g/m(3) of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICr Artigos e Materiais de Revistas Científicas - LIM/05 Artigos e Materiais de Revistas Científicas - ODS/03 |
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File | Description | Size | Format | |
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art_YARIWAKE_Chronic_exposure_to_PM25_aggravates_SLE_manifestations_in_2021.PDF | publishedVersion (English) | 3.11 MB | Adobe PDF | View/Open |
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