Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

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art_POLANCZYK_Disability_adjusted_life_years_(DALYs)_for_291_diseases_2012.PDF (1.11 MB)
Citações na Scopus
6814
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
MURRAY, Christopher J. L.
VOS, Theo
LOZANO, Rafael
NAGHAVI, Mohsen
FLAXMAN, Abraham D.
MICHAUD, Catherine
EZZATI, Majid
SHIBUYA, Kenji
SALOMON, Joshua A.
ABDALLA, Safa
Citação
LANCET, v.380, n.9859, p.2197-2223, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights. Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990; 44% decline in DALYs), stroke (fifth in 1990; 19% increase), diarrhoeal diseases (second in 1990; 51% decrease), and HIV/AIDS (33rd in 1990; 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions. Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results.
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URI
https://observatorio.fm.usp.br/handle/OPI/4240
Referências
  1. Adair T, 2012, INT J TUBERC LUNG D, V16, P1699, DOI 10.5588/ijtld.12.0251
  2. Ahern RM, 2011, POPUL HEALTH METR, V9, DOI 10.1186/1478-7954-9-8
  3. [Anonymous], 2005, NCMH BACKGR PAP BURD
  4. [Anonymous], 2011, VIET NAM BURD DIS IN
  5. [Anonymous], 2006, HIGHL HLTH EST 2005
  6. Begg SJ, 2008, MED J AUSTRALIA, V188, P36
  7. Bowie C, 2007, MALAWI MED J, V18, P104
  8. Bradshaw D, 2003, SAMJ S AFR MED J, V93, P682
  9. Bundhamcharoen K, 2011, BMC PUBLIC HEALTH, V11, DOI 10.1186/1471-2458-11-53
  10. Bundhamcharoen K, 2002, THAI WORKING GROUP B
  11. Carp FM, 2000, ELDER ABUSE FAMILY I
  12. Chalk R., 1998, VIOLENCE FAMILIES AS
  13. CHAMIE M, 1995, DISABIL REHABIL, V17, P323
  14. Chapman G, 2006, TROP MED INT HEALTH, V11, P660, DOI 10.1111/j.1365-3156.2006.01601.x
  15. Coyte PC, 1998, ARTHRIT CARE RES, V11, P315, DOI 10.1002/art.1790110503
  16. de Salud M, 2006, ESTUDIO CARGA ENFERM
  17. Dgedge M, 2001, B WORLD HEALTH ORGAN, V79, P546
  18. Dodhia H, 2008, J PUBLIC HEALTH-UK, V30, P313, DOI 10.1093/pubmed/fdn015
  19. Escobar M, 1994, CARGA ENFERMEDAD COL
  20. Fouad D, 2007, ECOMOD2007 C
  21. Frenk J, 2010, LANCET, V376, P1923, DOI 10.1016/S0140-6736(10)61854-5
  22. Friedman C, 2004, J OCCUP ENVIRON MED, V46, P3, DOI 10.1097/01.jom.0000105915.59342.9a
  23. Fukuda Y, 1999, J HLTH WELFARE STAT, V46, P28
  24. Gadelha AMJ, 1998, PROJETO CARGA DOENCA
  25. Genova-Maleras R, 2012, PUBLIC HEALTH, V126, P1024, DOI 10.1016/j.puhe.2012.08.012
  26. Green S, 2007, BURDEN DIS ILLNESS U
  27. Grosse SD, 2009, PUBLIC HEALTH REP, V124, P197
  28. Heise L L, 1998, Violence Against Women, V4, P262, DOI 10.1177/1077801298004003002
  29. Hsairi M, 2003, Sante Publique, V15, P25
  30. Hu GP, 2010, CHEST, V138, P20, DOI 10.1378/chest.08-2114
  31. Hurley Susan F, 2007, Cost Eff Resour Alloc, V5, P2, DOI 10.1186/1478-7547-5-2
  32. Hyder AA, 1998, AM J PUBLIC HEALTH, V88, P196, DOI 10.2105/AJPH.88.2.196
  33. Hyder AA, 2012, AM J PUBLIC HEALTH, V102, P1061, DOI 10.2105/AJPH.2011.300563
  34. Hyder AA, 2000, AM J PUBLIC HEALTH, V90, P1235, DOI 10.2105/AJPH.90.8.1235
  35. Ikeda S, 1998, J HLTH CARE SOC, V8, P83
  36. Jankovic S, 2007, EUR J PUBLIC HEALTH, V17, P80, DOI 10.1093/eurpub/ckl072
  37. King G, 2000, AM J POLIT SCI, V44, P347, DOI 10.2307/2669316
  38. Kominski GF, 2002, PUBLIC HEALTH REP, V117, P185, DOI 10.1093/phr/117.2.185
  39. Kosen S, 1998, ESTIMATION NATL BURD
  40. Kurmi OP, 2010, THORAX, V65, P221, DOI 10.1136/thx.2009.124644
  41. Lai T, 2009, EUR J PUBLIC HEALTH, V19, P541, DOI 10.1093/eurpub/ckp038
  42. Lapostolle A, 2008, EUR J PUBLIC HEALTH, V18, P195, DOI 10.1093/eurpub/ckm109
  43. Leonardi M, 2006, LANCET, V368, P1219, DOI 10.1016/S0140-6736(06)69498-1
  44. Logan WPD, 1950, POP STUD-J DEMOG, V4, P132, DOI 10.2307/2172133
  45. Lopez AD, 2006, GLOBAL BURDEN OF DISEASE AND RISK FACTORS, P1, DOI 10.1596/978-0-8213-6262-4
  46. Lopez AD, 2002, WORLD MORTALITY 2000
  47. Lopez FC, 2009, REV ESP SALUD PUBLIC, V83, P137
  48. Lozada P, 1999, PESO ENFERMEDAD ECUA
  49. Lozano R., 1997, PESO ENFERMEDAD MEXI, P23
  50. Lozano R, 2009, CARGA ENFERMEDAD MUN
  51. Lozano R, 2012, LANCET, V380, P2095, DOI 10.1016/S0140-6736(12)61728-0
  52. Lozano R.C., 1995, J INT DEV, V7, P555, DOI 10.1002/JID.3380070314
  53. Mariotti S, 2003, EUR J EPIDEMIOL, V18, P513
  54. Marks G, 1997, HLTH ADULT BRITAIN 1
  55. Mathers CD, 2000, MED J AUSTRALIA, V172, P592
  56. Mathers CD, 2007, PLOS NEGLECT TROP D, V1, DOI 10.1371/journal.pntd.0000114
  57. Mathers CD, 2001, B WORLD HEALTH ORGAN, V79, P1076
  58. Mathers CD, 2001, LANCET, V357, P1685, DOI 10.1016/S0140-6736(00)04824-8
  59. Mathur Prashant, 2011, Indian J Community Med, V36, pS72, DOI 10.4103/0970-0218.94713
  60. McKenna MT, 2005, AM J PREV MED, V28, P415, DOI 10.1016/j.amepre.2005.02.009
  61. Melse JM, 2000, AM J PUBLIC HEALTH, V90, P1241, DOI 10.2105/AJPH.90.8.1241
  62. Michaud Catherine M, 2006, Popul Health Metr, V4, P11, DOI 10.1186/1478-7954-4-11
  63. Ministerio de Salud, 2007, EST CARG ENF CARG AT
  64. Ministerio de Salud de Costa Rica, 2008, MED CARG ENF COST RI
  65. Ministry of Health, 2001, MIN HLTH PUBL HLTH I
  66. Ministry of Health, 2004, BURD DIS FIN REP
  67. Murray C, 1996, GLOBAL HLTH STAT COM
  68. Murray C, 2003, HLTH SYSTEMS PERFORM, P301
  69. Murray CJ, 1996, GLOBAL BURDEN DIS CO
  70. Murray CJL, 2002, SUMMARY MEASURES POP
  71. Murray CJL, 1997, LANCET, V349, P1498, DOI 10.1016/S0140-6736(96)07492-2
  72. Murray CJL, 2012, LANCET, V379, P413, DOI 10.1016/S0140-6736(12)60034-8
  73. Murray CJL, 1997, LANCET, V349, P1269, DOI 10.1016/S0140-6736(96)07493-4
  74. Murray CJL, 1997, LANCET, V349, P1347, DOI 10.1016/S0140-6736(96)07494-6
  75. Murray CJL, 1997, LANCET, V349, P1436, DOI 10.1016/S0140-6736(96)07495-8
  76. Murray CJL, 2012, LANCET, V380, P2063, DOI 10.1016/S0140-6736(12)61899-6
  77. Naghavi M, 2010, POPUL HEALTH METR, V8, DOI 10.1186/1478-7954-8-9
  78. Norman R, 2006, REVISED BURDEN DIS E
  79. Oh IH, 2011, J KOREAN MED ASSOC, V54, P646
  80. Peden M., 2004, WORLD REPORT ROAD TR
  81. Peterson S, 1998, SJUKDOMSBORDAN SVERI
  82. Phua HP, 2009, SINGAP MED J, V50, P468
  83. Polinder S, 2012, EPIDEMIOL REV, V34, P17, DOI 10.1093/epirev/mxr022
  84. Prince M, 2007, LANCET, V370, P859, DOI 10.1016/S0140-6736(07)61238-0
  85. Reiss A, 1993, VIOLENCE FAMILIES UN
  86. Rodriguez J, 2008, CARGA ENFERMEDAD COL
  87. Rodriguez J, 2000, CARGA GLOBAL ENFERME
  88. Salas Vergara J, 1996, ESTUDIO PRIORIDADES
  89. Salomon JA, 2012, LANCET, V380, P2129, DOI 10.1016/S0140-6736(12)61680-8
  90. Samutharuk B, 1999, MEASUREMENT DIS BURD
  91. Schiamberg LB, 1999, J ELDER ABUSE NEGL, V11, P79, DOI 10.1300/J084v11n01_05
  92. Schopper D, 2000, INT J EPIDEMIOL, V29, P871, DOI 10.1093/ije/29.5.871
  93. Seuc AH, 2010, CAD SAUDE PUBLICA, V26, P615, DOI 10.1590/S0102-311X2010000300018
  94. Stevens G, 2008, PLOS MED, V5, P900, DOI 10.1371/journal.pmed.0050125
  95. The Thai Working Group on Burden of Disease and Injury, 2004, J HEALTH SCI, V13, P239
  96. Thomas C, 2004, DISABIL SOC, V19, P569, DOI 10.1080/0968759042000252506
  97. United Nations, UN ROAD SAF
  98. Velasquez Valdivia A., 2006, ANALISIS ESTUDIO CAR
  99. Vos T, 2012, LANCET, V380, P2163, DOI 10.1016/S0140-6736(12)61729-2
  100. Wang HD, 2012, LANCET, V380, P2071, DOI 10.1016/S0140-6736(12)61719-X
  101. WHO, REG BURD DIS EST 200
  102. World Bank, 1993, WORLD DEV REP 1993 I
  103. World Health Organization, WORLD HLTH REP 2001
  104. World Health Organization, WORLD HLTH REP 2000
  105. World Health Organization, WORLD HLTH REP 2004
  106. World Health Organization, 2010, VIOL PREV EV
  107. World Health Organization, WORLD HLTH REP 2002
  108. World Health Organization, WORLD HLTH REP 1999
  109. YELIN E, 1995, ARTHRITIS RHEUM, V38, P1351, DOI 10.1002/art.1780381002
  110. Yoon SJ, 2007, J KOREAN MED SCI, V22, P518
  111. Yusoff AF, MALAYSIAN BURDEN DIS
  112. Zhou SC, 2009, BMC PUBLIC HEALTH, V9, DOI 10.1186/1471-2458-9-188

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21