Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects

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Arquivos
art_CARPENA_Sleeprelated_traits_and_attentiondeficithyperactivity_disorder_comorbidity_Shared_genetic_2021.PDF (2.46 MB)
Citações na Scopus
12
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS LTD
Autores
CARPENA, Marina Xavier
MARTINS-SILVA, Thais
GENRO, Julia P.
HUTZ, Mara Helena
ROHDE, Luis Augusto
TOVO-RODRIGUES, Luciana
Citação
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v.22, n.10, p.778-791, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives To evaluate the shared genetic components, common pathways and causal relationship between ADHD and sleep-related phenotypes Methods We used the largest genome-wide association summary statistics available for attention-deficit/hyperactivity disorder (ADHD) and various sleep-related phenotypes (insomnia, napping, daytime dozing, snoring, ease getting up, daytime sleepiness, sleep duration and chronotype). We estimated the genomic correlation using cross-trait linkage disequilibrium score regression (LDSR) and investigated the potential common mechanisms using gene-based cross-trait metanalyses and functional enrichment analyses. The causal effect was estimated using two-sample Mendelian randomisation (TSMR), using the inverse variance weighted method as the main estimator. Results A positive genomic correlation between insomnia, daytime napping, daytime dozing, snoring, daytime sleepiness, short and long sleep duration, and ADHD was observed. Insomnia, daytime sleepiness, and snoring shared genes with ADHD, that are involved in neurobiological functions and regulatory signalling pathways. The TSMR supported a causal effect of insomnia, daytime napping, and short sleep duration on ADHD, and of ADHD on long sleep duration and chronotype. Conclusion Comorbidity between sleep phenotypes and ADHD may be mediated by common genetic factors that play an important role in neuronal signalling pathways. A causal effect of sleep disturbances and short sleep duration on ADHD reinforced their role as predictors of ADHD.
Palavras-chave
ADHD, genetics, sleep, circadian rhythm, Mendelian randomisation
URI
https://observatorio.fm.usp.br/handle/OPI/44534
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - LIM/38
Artigos e Materiais de Revistas Científicas - LIM/39