Greater male than female variability in regional brain structure across the lifespan

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art_WIERENGA_Greater_male_than_female_variability_in_regional_brain_2022.PDF (4.27 MB)
Citações na Scopus
52
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
WIERENGA, Lara M.
DOUCET, Gaelle E.
DIMA, Danai
AGARTZ, Ingrid
AGHAJANI, Moji
AKUDJEDU, Theophilus N.
ALBAJES-EIZAGIRRE, Anton
ALNAES, Dag
I, Kathryn Alpert
ANDREASSEN, Ole A.
Citação
HUMAN BRAIN MAPPING, v.43, n.1, Special Issue, p.470-499, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/44549
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/21