Banana green peels extract protects against nonalcoholic fatty liver disease in high-fat-fed mice through modulation of lipid metabolism and inflammation
Carregando...
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
ABREU, Iracelle Carvalho
FIAMONCINI, Jarlei
ALVARENGA, Jose Fernando Rinaldi de
Citação
PHYTOTHERAPY RESEARCH, v.36, n.2, p.951-962, 2022
Resumo
We investigate the effect of the banana green peels extract (BPE) as a preventive treatment against NAFLD in high-fat diet fed mice. Mice received daily doses of 100 or 250 mg/kg of BPE for 12 weeks along with the high-fat diet. BPE reduced weight gain (p < .0001), adipose tissue hypertrophy (p < .0001), and improved glucose homeostasis (p < .0001). Plasma levels of glucose-dependent insulinotropic polypeptide, triglycerides, total cholesterol, LDL-cholesterol, non-esterified fatty acids, aspartate and alanine transaminase, leptin, and resistin were decreased in BPE treated mice (p < .05). BPE effects on lipid metabolism were associated with decreased gene expression of lipogenic enzymes and increased expression of enzymes related to fatty acid and cholesterol degradation (p < .05). Plasma and liver bile acid (BA) profiles were modulated by BPE, with positive correlations between specific BA and UCP-1, CPT-1 and PGC-1 beta expression in brown adipose tissue (p < .05). BPE reduced hepatic steatosis and inflammation, possibly due to reduced p65 NF-kappa B nuclear translocation (p < .05) and modulation of oxidative stress (p < .05). These data indicate that BPE is a source of phytochemical compounds with promising effects toward the prevention of metabolic disorders associated with obesity.
Palavras-chave
banana green peels, inflammation, lipid metabolism, Musa cavendish, nonalcoholic fatty liver disease, oxidative stress
Referências
- Alvehus M, 2010, OBESITY, V18, P879, DOI 10.1038/oby.2010.22
- Amirinejad A, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-021-03396-x
- Amirinejad A, 2020, J SCI FOOD AGR, V100, P1787, DOI 10.1002/jsfa.10215
- Barroso WA, 2019, TOXICOL IN VITRO, V59, P179, DOI 10.1016/j.tiv.2019.04.020
- Chung MY, 2012, J NUTR BIOCHEM, V23, P361, DOI 10.1016/j.jnutbio.2011.01.001
- Estes C, 2018, J HEPATOL, V69, P896, DOI 10.1016/j.jhep.2018.05.036
- Freedman BD, 2005, J BIOL CHEM, V280, P17118, DOI 10.1074/jbc.M407539200
- Fromme T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37464-z
- Gerard P, 2016, CELL MOL LIFE SCI, V73, P147, DOI 10.1007/s00018-015-2061-5
- Ghaffarzadegan T, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-40272-8
- Gu M, 2020, PHYTOTHER RES, V34, P3063, DOI 10.1002/ptr.6743
- Hallsworth K, 2019, JHEP REP, V1, P468, DOI 10.1016/j.jhepr.2019.10.008
- HORIGOME T, 1992, BRIT J NUTR, V68, P231, DOI 10.1079/BJN19920080
- Huang FJ, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-12896-x
- Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701
- Li TG, 2010, HEPATOLOGY, V52, P678, DOI 10.1002/hep.23721
- Meyer K, 2002, INT J ONCOL, V21, P1175
- Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
- Navghare V, 2016, INDIAN J CLIN BIOCHE, V31, P380, DOI 10.1007/s12291-016-0548-y
- Noureddin Mazen, 2018, Curr Hepatol Rep, V17, P350, DOI 10.1007/s11901-018-0425-7
- Oliveira L, 2008, J AGR FOOD CHEM, V56, P9520, DOI 10.1021/jf801709t
- Hernandez VO, 2018, NUTR HOSP, V35, P588, DOI 10.20960/nh.1506
- Pari L, 1999, J ETHNOPHARMACOL, V68, P321, DOI 10.1016/S0378-8741(99)00088-4
- Perino A, 2021, PHYSIOL REV, V101, P683, DOI 10.1152/physrev.00049.2019
- Sangsefidi ZS, 2021, PHYTOTHER RES, V35, P5259, DOI 10.1002/ptr.7199
- Sarma PP, 2021, FOOD FUNCT, V12, P4749, DOI [10.1039/d1fo00477h, 10.1039/D1FO00477H]
- Schmittgen TD, 2008, NAT PROTOC, V3, P1101, DOI 10.1038/nprot.2008.73
- Simental-Mendia LE, 2021, ADV EXP MED BIOL, V1308, P257, DOI 10.1007/978-3-030-64872-5_18
- Tessari P, 2009, NUTR METAB CARDIOVAS, V19, P291, DOI 10.1016/j.numecd.2008.12.015
- Victorino VJ, 2016, TUMOR BIOL, V37, P6035, DOI 10.1007/s13277-015-4449-0
- Vijayakumar S, 2008, FITOTERAPIA, V79, P279, DOI 10.1016/j.fitote.2008.01.007
- Wang R, 2016, EXP THER MED, V11, P1947, DOI 10.3892/etm.2016.3155
- Watanabe M, 2006, NATURE, V439, P484, DOI 10.1038/nature04330
- Wei ML, 2020, EBIOMEDICINE, V55, DOI 10.1016/j.ebiom.2020.102766
- Xiong Y, 2021, LIFE SCI, V268, DOI 10.1016/j.lfs.2020.119000
- Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
- Zhang CB, 2014, AM J PHYSIOL-ENDOC M, V307, pE305, DOI 10.1152/ajpendo.00034.2014
- Zhu Y, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-00473-9