Bipolar symptoms, somatic burden, and functioning in older-age bipolar disorder: Analyses from the Global Aging & Geriatric Experiments in Bipolar Disorder Database project
Carregando...
Citações na Scopus
22
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY
Autores
SAJATOVIC, Martha
DOLS, Annemiek
REJ, Soham
ALMEIDA, Osvaldo P.
BEUNDERS, Alexandra J. M.
BLUMBERG, Hilary P.
BRIGGS, Farren B. S.
FORESTER, Brent P.
PATRICK, Regan E.
Citação
BIPOLAR DISORDERS, v.24, n.2, p.195-206, 2022
Resumo
Objective Literature on older-age bipolar disorder (OABD) is limited. This first-ever analysis of the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD) investigated associations among age, BD symptoms, comorbidity, and functioning. Methods This analysis used harmonized, baseline, cross-sectional data from 19 international studies (N = 1377). Standardized measures included the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAM-D), Montgomery-Asberg Depression Rating Scale (MADRS), and Global Assessment of Functioning (GAF). Results Mean sample age was 60.8 years (standard deviation [SD] 12.2 years), 55% female, 72% BD I. Mood symptom severity was low: mean total YMRS score of 4.3 (SD 5.4) and moderate-to-severe depression in only 22%. Controlled for sample effects, both manic and depressive symptom severity appeared lower among older individuals (p's < 0.0001). The negative relationship between older age and symptom severity was similar across sexes, but was stronger among those with lower education levels. GAF was mildly impaired (mean =62.0, SD = 13.3) and somatic burden was high (mean =2.42, SD = 1.97). Comorbidity burden was not associated with GAF. However, higher depressive (p < 0.0001) and manic (p < 0.0001) symptoms were associated with lower GAF, most strongly among older individuals. Conclusions Findings suggest an attenuation of BD symptoms in OABD, despite extensive somatic burden. Depressive symptom severity was strongly associated with worse functioning in older individuals, underscoring the need for effective treatments of BD depression in older people. This international collaboration lays a path for the development of a better understanding of aging in BD.
Palavras-chave
aging, bipolar disorder, depression, functioning, mania, medical burden
Referências
- Al Jurdi RK, 2008, AM J GERIAT PSYCHIAT, V16, P922, DOI 10.1097/JGP.0b013e318187135f
- Buoli M, 2019, CNS SPECTRUMS, V24, P589, DOI 10.1017/S1092852918001529
- Camp DL, 2002, SOC SCI MED, V55, P823, DOI 10.1016/S0277-9536(01)00205-2
- Carvalho AF, 2020, NEW ENGL J MED, V383, P58, DOI 10.1056/NEJMra1906193
- Chang-Quan H, 2010, INT J PSYCHIAT MED, V40, P109, DOI 10.2190/PM.40.1.i
- Chaudhry S, 2005, MED CARE, V43, P607, DOI 10.1097/01.mlr.0000163658.65008.ec
- Coryell W, 2009, PSYCHOL MED, V39, P1247, DOI 10.1017/S0033291709005534
- Crump C, 2013, JAMA PSYCHIAT, V70, P931, DOI 10.1001/jamapsychiatry.2013.1394
- Daly L, 2019, AM J GERIAT PSYCHIAT, V19, P30336
- Dickey B., 1996, OUTCOME ASSESSMENT C
- Dols A, 2016, INT J GERIATR PSYCH, V31, P1295, DOI 10.1002/gps.4534
- Fiedorowicz JG, 2011, AM J PSYCHIAT, V168, P40, DOI 10.1176/appi.ajp.2010.10030328
- Gildengers AG, 2008, AM J GERIAT PSYCHIAT, V16, P194, DOI 10.1097/JGP.0b013e318157c5b1
- HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
- Jeon HJ, 2016, PSYCHIAT INVEST, V13, P265, DOI 10.4306/pi.2016.13.3.265
- Kemp DE, 2014, ACTA PSYCHIAT SCAND, V129, P24, DOI 10.1111/acps.12101
- Kessing LV, 2006, BIPOLAR DISORD, V8, P56, DOI 10.1111/j.1399-5618.2006.00278.x
- Kessing LV, 2004, BRIT J PSYCHIAT, V185, P372, DOI 10.1192/bjp.185.5.372
- Lala SV, 2012, J GERIATR PSYCH NEUR, V25, P20, DOI 10.1177/0891988712436683
- LINN BS, 1968, J AM GERIATR SOC, V16, P622, DOI 10.1111/j.1532-5415.1968.tb02103.x
- MILLER MD, 1992, PSYCHIAT RES, V41, P237, DOI 10.1016/0165-1781(92)90005-N
- MONTGOMERY SA, 1979, BRIT J PSYCHIAT, V134, P382, DOI 10.1192/bjp.134.4.382
- Nivoli AMA, 2014, ACTA PSYCHIAT SCAND, V130, P364, DOI 10.1111/acps.12272
- O'Rourke N, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0187632
- Pallaskorpi S, 2019, J AFFECT DISORDERS, V246, P806, DOI 10.1016/j.jad.2018.12.093
- Population Division . Department of Economic and Social Affairs, 1950, WORLD POP AG
- Russell SJ, 2005, AUST NZ J PSYCHIAT, V39, P187, DOI 10.1111/j.1440-1614.2005.01542.x
- Sajatovic M, 2004, PSYCHIAT SERV, V55, P1014, DOI 10.1176/appi.ps.55.9.1014
- Sajatovic M, 2008, AM J GERIAT PSYCHIAT, V16, P718, DOI 10.1097/JGP.0b013e3180488346
- Sajatovic M, 2019, BIPOLAR DISORD, V21, P642, DOI 10.1111/bdi.12795
- Sajatovic M, 2015, BIPOLAR DISORD, V17, P689, DOI 10.1111/bdi.12331
- Samame C, 2013, BIPOLAR DISORD, V15, P633, DOI 10.1111/bdi.12077
- Saracci R, 2007, INT J EPIDEMIOL, V36, P244, DOI 10.1093/ije/dyl263
- Shavers VL, 2007, J NATL MED ASSOC, V99, P1013
- Sonnenberg CM, 2000, ACTA PSYCHIAT SCAND, V101, P286, DOI 10.1111/j.1600-0447.2000.tb10927.x
- Tsai SY, 2009, AM J GERIAT PSYCHIAT, V17, P1004, DOI 10.1097/JGP.0b013e3181b7ef2a
- YOUNG RC, 1978, BRIT J PSYCHIAT, V133, P429, DOI 10.1192/bjp.133.5.429