Chikungunya virus as a trigger for different renal disorders: an exploratory study

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art_COSTA_Chikungunya_virus_as_a_trigger_for_different_renal_2022.PDF (1.55 MB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER HEIDELBERG
Autores
COSTA, Denise Maria do Nascimento
MACHADO, Carlos Eduardo
BRITO, Dyego Jose
OI, Samira
BARROS, Flavio Henrique
FIGUEIREDO, Luiz Tadeu
ARAUJO, Stanley Almeida
LADCHUMANANANDASIVAM, Francisco
REIS, Marlene Antonia dos
Citação
JOURNAL OF NEPHROLOGY, v.35, n.5, p.1437-1447, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction Chikungunya virus was detected in cases of acute chikungunya fever in renal tissue. However, chikungunya virus-related kidney injury still lacks characterization, and it is unknown whether the kidneys are reservoirs for the virus. We sought to detect histopathological changes and viral antigens in renal tissue, and to evaluate kidney injury markers in different phases of chikungunya fever. Methods Two groups were evaluated in this exploratory study: patients with biopsy-proven kidney injury established after chikungunya fever, and patients with post-chikungunya fever chronic joint manifestations without known kidney injury, in whom we actively searched for kidney injury markers. Results In the first group, 15 patients had kidney injury 0.5-24 months after chikungunya fever. The most frequent histopathological diagnoses were glomerular lesions. No viral antigens were detected in renal tissue. High-risk genotypes were detected in patients with atypical hemolytic uremic syndrome and focal and segmental glomerulosclerosis. In the second group, 114 patients had post-chikungunya fever joint manifestations on average for 35.6 months. Mean creatinine and proteinuria were 0.9 mg/dl and 71.5 mg/day, respectively. One patient had isolated hematuria. There was no indication for renal biopsy in this group. Conclusions Several histopathological features were found after chikungunya fever, without virus detection in renal tissue. These findings suggest that chikungunya virus may trigger kidney lesions with varying degrees of severity at different stages of infection. However, the probability that this virus replicates in the renal tissue seems unlikely. [GRAPHICS] .
Palavras-chave
Chikungunya virus, Chikungunya fever, Kidney injury, Glomerulopathy
URI
https://observatorio.fm.usp.br/handle/OPI/48305
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/29
Artigos e Materiais de Revistas Científicas - ODS/07