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https://observatorio.fm.usp.br/handle/OPI/48479
Title: | Impact of SARS-CoV-2 on saliva: TNF-alpha, IL-6, IL-10, lactoferrin, lysozyme, IgG, IgA, and IgM |
Authors: | SANTOS, Julia Gaspar de Oliveira; MIGUEIS, Debora Petrungaro; AMARAL, Jonatas Bussador do; BACHI, Andre Luis Lacerda; BOGGI, Alexandre Coelho; THAMBOO, Andrew; VOEGELS, Richard Louis; PEZATO, Rogerio |
Citation: | JOURNAL OF ORAL BIOSCIENCES, v.64, n.1, p.108-113, 2022 |
Abstract: | Objectives: Understanding the role of certain salivary components, such as TNF-alpha, IL-6, IL-10, lactoferrin, lysozyme, IgG, IgA, and IgM, in airway defense during the ongoing SARS-CoV-2 pandemic is essential. The salivary immune barrier of patients with COVID-19 may play a role in their prognosis. The present study aims to evaluate the impact of SARS-CoV-2 on saliva composition. Methods: A longitudinal study was carried out with male and female firefighters aged 24-48 years. The study sample (n = 34) was divided into 3 groups: asymptomatic volunteers with a negative polymerase chain reaction (PCR) test for SARS-CoV-2 (group 1, Control, n = 21); patients with symptoms of COVID-19 of less than 7 days' duration and a diagnosis of SARS-CoV-2 infection by PCR (group 2, COVID-19, n = 13); and recovered patients from group 2 who were free of COVID-19 symptoms for at least 2 months (group 3, post-COVID-19 recovery, n = 13). All groups underwent real-time PCR to detect the presence of SARS-CoV-2, as well as analysis of the salivary concentrations of TNF-alpha, IL-6, IL-10, lactoferrin, lysozyme, IgG, IgA, and IgM by the ELISA method. Results: Lactoferrin concentrations were significantly decreased in the infected group (COVID-19) when compared to those not infected by SARS-CoV-2 (control) (p = 0.032). IgA concentrations were decreased in the COVID-19 and post-COVID-19 groups compared to the control group (p = 0.005 and p = 0.016, respectively). Comparison of the COVID-19 and post-COVID-19 groups also revealed an increase in IgM concentrations during acute SARS-CoV-2 infection (p = 0.010). Conclusion: SARS-CoV-2 alters the composition of the salivary immune barrier. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - COVID-19 Artigos e Materiais de Revistas Científicas - FM/MOF Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/32 Artigos e Materiais de Revistas Científicas - ODS/03 |
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