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https://observatorio.fm.usp.br/handle/OPI/53875
Title: | Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA) |
Authors: | YANAGIMORI, Marcela; FERNANDES, Mariana D.; GARCIA, Michelle L.; SCUDELLER, Paula G.; CARVALHO, Carlos R. R.; EDWARDS, Bradley; LORENZI-FILHO, Geraldo; GENTA, Pedro R. |
Citation: | SCIENTIFIC REPORTS, v.13, n.1, 2023 |
Abstract: | Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to trigger an arousal from sleep. The impact of COMISA on AT is not known. We hypothesized that a low AT is more common among COMISA than among patients with OSA without insomnia. Participants referred for OSA diagnosis underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score >= 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) >= 15 events/h. Low AT was determined using a previously validated score based on 3 polysomnography variables (AHI, nadir SpO(2) and the frequency of hypopneas). OSA-only (n = 51) and COMISA (n = 52) participants had similar age (61[52-68] vs 60[53-65] years), body-mass index (31.3[27.7-36.2] vs 32.2[29.5-38.3] kg/m(2)) and OSA severity (40.2[27.5-60] vs 37.55[27.9-65.2] events/h): all p = NS. OSA-only group had significantly more males than the COMISA group (58% vs 33%, p = 0.013. The proportion of participants with a low AT among OSA-only and COMISA groups was similar (29 vs 33%, p = NS). The similar proportion of low AT among COMISA and patients with OSA suggests that the respiratory arousal threshold may not be related to the increased arousability of insomnia. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCP Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InCor Artigos e Materiais de Revistas Científicas - LIM/09 Artigos e Materiais de Revistas Científicas - LIM/63 |
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