Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/53915
Title: | Potassium-competitive acid blockers, a new therapeutic class, and their role in acid-related diseases: a narrative review |
Authors: | DOMINGUES, Gerson; CHINZON, Decio; MORAES-FILHO, Joaquim Prado P.; SENRA, Juliana Tosta; PERROTTI, Marcos; ZATERKA, Schlioma |
Citation: | GASTROENTEROLOGY REVIEW-PRZEGLAD GASTROENTEROLOGICZNY, v.18, n.1, p.47-55, 2023 |
Abstract: | Introduction: A new therapeutic class, potassium-competitive acid blockers (P-CABs), has emerged in Brazil to promote a superior antisecretory effect addressing the unmet needs related to acid-related disease management. Vonoprazan fumarate showed a good safety profile and was approved by the Brazilian regulatory agency - ANVISA.Aim: This narrative review was conducted to review the general concepts regarding P-CABs, focussing on vonoprazan fu-marate.Material and methods: A literature search was conducted through April-May 2021 using official databases with a combi-nation of MeSH controlled vocabulary and text words. The authors selected articles that described pivotal and novel insights about P-CABs and vonoprazan fumarate.Results: Vonoprazan is a drug of the P-CABs class newly approved for the management of acid-related diseases in Brazil. P-CABs achieve rapid, potent, and prolonged acid suppression (including night-time) and promise to address some unmet clinical needs in GERD. Furthermore, considering the difficulties encountered in attaining effective symptomatic control - particularly at night - using currently available PPIs, this new drug class is promising.Conclusions: This review brings important information about vonoprazan, a new therapeutic option in Brazil, which may be considered as a valuable tool for managing acid-related diseases. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICHC |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_DOMINGUES_Potassiumcompetitive_acid_blockers_a_new_therapeutic_class_and_2023.PDF | publishedVersion (English) | 125.37 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.