Non-motor effects of deep brain stimulation in Parkinson?s disease motor subtypes
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Citações na Scopus
2
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
JOST, Stefanie T.
KONITSIOTI, Agni
LOEHRER, Philipp A.
ASHKAN, Keyoumars
RIZOS, Alexandra
SAUERBIER, Anna
GHILARDI, Maria Gabriela dos Santos
ROSENKRANZ, Franz
STROBEL, Lena
GRONOSTAY, Alexandra
Citação
PARKINSONISM & RELATED DISORDERS, v.109, article ID 105318, 10p, 2023
Resumo
Introduction: Deep brain stimulation (DBS) is a well-established treatment for patients with Parkinson's disease (PD) improving quality of life, motor, and non-motor symptoms. However, non-motor effects in PD subtypes are understudied. We hypothesized that patients with 'postural instability and gait difficulty' (PIGD) experience more beneficial non-motor effects than 'tremor-dominant' patients undergoing DBS for PD.Methods: In this prospective, observational, international multicentre study with a 6-month follow-up, we assessed the Non-Motor Symptom Scale (NMSS) as primary and the following secondary outcomes: Unified PD Rating Scale-motor examination (UPDRS-III), Scales for Outcomes in PD (SCOPA)-activities of daily living (ADL) and-motor complications, PDQuestionnaire-8 (PDQ-8), and levodopa-equivalent daily dose (LEDD). We analysed within-group longitudinal changes with Wilcoxon signed-rank test and Benjamini-Hochberg correction for multiple comparisons. Additionally, we explored outcome between-group differences of motor subtypes with Mann-Whitney U-tests.Results: In 82 PIGD and 33 tremor-dominant patients included in this study, baseline NMSS total scores were worse in PIGD patients, both groups experienced postoperative improvements of the NMSS sleep/fatigue domain, and between-group differences in postoperative outcomes were favourable in the PIGD group for the NMSS total and miscellaneous domain scores.Conclusions: This study provides evidence of a favourable outcome of total non-motor burden in PIGD compared to tremor-dominant patients undergoing DBS for PD. These differences of clinical efficacy on non-motor aspects should be considered when advising and monitoring patients with PD undergoing DBS.
Palavras-chave
Deep brain stimulation, Nonmotor symptoms, Quality of life, Tremor-dominant, Postural instability and gait difficulty
Referências
- Ba F, 2016, CAN J NEUROL SCI, V43, P261, DOI 10.1017/cjn.2015.328
- Benabid AL, 2006, MOVEMENT DISORD, V21, pS168, DOI 10.1002/mds.20954
- Campbell M. J., 2009, STAT SQUARE ONE, DOI 10.1136/pmj.78.921.444-b
- Chaudhuri KR, 2007, MOVEMENT DISORD, V22, P1901, DOI 10.1002/mds.21596
- Cury RG, 2018, WORLD NEUROSURG, V114, pE559, DOI 10.1016/j.wneu.2018.03.033
- Dafsari H.S., MOVEMENT DISORD
- Dafsari HS, 2020, BRAIN STIMUL, V13, P1697, DOI 10.1016/j.brs.2020.09.019
- Dafsari HS, 2020, J NEUROL, V267, P1830, DOI 10.1007/s00415-020-09743-1
- Deuschl G, 2006, NEW ENGL J MED, V355, P896, DOI 10.1056/NEJMoa060281
- Eghlidos Z, 2022, ACTA NEUROL SCAND, V146, P115, DOI 10.1111/ane.13652
- Espay AJ, 2010, MOVEMENT DISORD, V25, P1456, DOI 10.1002/mds.23111
- Giannini G., 2019, MOVEMENT DISORD, V93, P97
- Hentz JG, 2015, MOVEMENT DISORD, V30, P1967, DOI 10.1002/mds.26435
- Herman T, 2015, J NEURAL TRANSM, V122, P1115, DOI 10.1007/s00702-014-1349-1
- Herzog J, 2006, BRAIN, V129, P3366, DOI 10.1093/brain/awl302
- HOEHN MM, 1967, NEUROLOGY, V17, P427, DOI 10.1212/WNL.17.5.427
- HUGHES AJ, 1992, J NEUROL NEUROSUR PS, V55, P181, DOI 10.1136/jnnp.55.3.181
- JANKOVIC J, 1990, NEUROLOGY, V40, P1529, DOI 10.1212/WNL.40.10.1529
- Jenkinson C, 1997, PSYCHOL HEALTH, V12, P805, DOI 10.1080/08870449708406741
- Jost ST, 2022, NPJ PARKINSONS DIS, V8, DOI 10.1038/s41531-022-00305-y
- Jost ST, 2021, NPJ PARKINSONS DIS, V7, DOI 10.1038/s41531-021-00174-x
- Jost ST, 2021, J PARKINSON DIS, V11, P323, DOI 10.3233/JPD-202278
- Jost ST, 2020, J NEUROL NEUROSUR PS, V91, P687, DOI 10.1136/jnnp-2019-322614
- Katz M, 2015, ANN NEUROL, V77, P710, DOI 10.1002/ana.24374
- Kleiner-Fisman G, 2006, MOVEMENT DISORD, V21, pS290, DOI 10.1002/mds.20962
- Knudsen K, 2019, PARKINSONISM RELAT D, V65, P217, DOI 10.1016/j.parkreldis.2019.05.023
- Kurtis MM, 2017, NPJ PARKINSONS DIS, V2, DOI 10.1038/npjparkd.2016.24
- Lazcano-Ocampo C., EUR J NEUROL
- Leta V, 2021, J PERS MED, V11, DOI 10.3390/jpm11080773
- Lhommee Eugenie, 2018, Lancet Neurol, V17, P223, DOI 10.1016/S1474-4422(18)30035-8
- Martinez-Martin P, 2011, MOVEMENT DISORD, V26, P399, DOI 10.1002/mds.23462
- Moro Elena, 2006, Expert Rev Neurother, V6, P1695, DOI 10.1586/14737175.6.11.1695
- Morris SB, 2008, ORGAN RES METHODS, V11, P364, DOI 10.1177/1094428106291059
- Nettersheim FS, 2019, NEUROIMAGE, V190, P118, DOI 10.1016/j.neuroimage.2018.04.030
- Picillo M, 2017, EUR J NEUROL, V24, P788, DOI 10.1111/ene.13290
- Ren JR, 2020, NEUROPSYCH DIS TREAT, V16, P2605, DOI 10.2147/NDT.S280960
- Sauerbier A., J NEUROL NEUROSUR PS, V11, P2021
- Sauerbier A, 2021, J NEUROL NEUROSUR PS, V92, P1313, DOI 10.1136/jnnp-2021-326131
- Sauerbier A, 2022, J PARKINSON DIS, V12, P453, DOI 10.3233/JPD-212823
- Sharma VD, 2018, FRONT NEUROL, V9, DOI 10.3389/fneur.2018.00697
- Stebbins GT, 2013, MOVEMENT DISORD, V28, P668, DOI 10.1002/mds.25383
- Stuart E.A., 2008, BEST PRACTICES QUASI
- Taylor JP, 2008, J NEUROL NEUROSUR PS, V79, P1318, DOI 10.1136/jnnp.2008.147629
- Thenganatt MA, 2014, JAMA NEUROL, V71, P499, DOI 10.1001/jamaneurol.2013.6233
- Tomlinson CL, 2010, MOVEMENT DISORD, V25, P2649, DOI 10.1002/mds.23429
- Trachani E, 2010, CLIN NEUROL NEUROSUR, V112, P213, DOI 10.1016/j.clineuro.2009.11.015
- Tremblay C, 2013, J NEUROL NEUROSUR PS, V84, P1265, DOI 10.1136/jnnp-2013-305021
- Trenkwalder C., MOV DISORD
- Verbaan D, 2011, PARKINSONISM RELAT D, V17, P632, DOI 10.1016/j.parkreldis.2011.05.022
- Wu Y, 2016, ACTA NEUROL SCAND, V133, P330, DOI 10.1111/ane.12461
- Xu CP, 2018, FRONT HUM NEUROSCI, V12, DOI 10.3389/fnhum.2018.00365
- Yoshida F, 2009, STEREOT FUNCT NEUROS, V87, P45, DOI 10.1159/000195719