Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years

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art_RIBEIRO_Major_discrepancy_between_clinical_diagnosis_of_death_and_2023.PDF (370.66 KB)
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1
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article
Data de publicação
2023
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Scopus
Web of Science
PubMed
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ELSEVIER ESPANA
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CLINICS, v.78, article ID 100184, 6p, 2023
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Unidades Organizacionais
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Objectives: To evaluate the inconsistency between clinical diagnosis of death and autopsy findings in adolescents with chronic diseases.Methods: A cross-sectional study including a sample of adolescents' autopsies who died in a pediatric and adoles-cent tertiary hospital over 18 consecutive years. During this period, there were n = 2912 deaths, and n = 581/ 2912(20%) occurred in adolescents. Of these, n = 85/581(15%) underwent autopsies and were analyzed. Further results were divided into two groups: Goldman classes I or II (high disagreement between main clinical diagnosis of death and anatomopathological findings, n = 26) and Goldman classes III, IV or V (low or no disagreement between these two parameters, n = 59).Results: Median age at death (13.5 [10-19] vs. 13 [10-19] years, p = 0.495) and disease duration (22 [0-164] vs. 20 [0-200] months, p = 0.931), and frequencies for males (58% vs. 44%, p = 0.247) were similar between class I/II vs. class III/IV/V. The frequency of pneumonia (73% vs. 48%, p = 0.029), pulmonary abscess (12% vs. 0%, p = 0.026), as well as isolation of yeast (27% vs. 5%, p = 0.008), and virus (15% vs. 2%, p = 0.029) identified in the autopsy, were significantly higher in adolescents with Goldman class I/II compared to those with Goldman class III/IV/V. In contrast, cerebral edema was significantly lower in adolescents of the first group (4% vs. 25%, p = 0.018).Conclusion: This study showed that 30% of the adolescents with chronic diseases had major discrepancies between clinical diagnosis of death and autopsy findings. Pneumonia, pulmonary abscess, as well as isolation of yeast and virus were more frequently identified at autopsy findings in the groups with major discrepancies.
Palavras-chave
Autopsy, Death, Adolescent, Chronic diseases, Pneumonia, Yeast
URI
https://observatorio.fm.usp.br/handle/OPI/54058
Referências
  1. Alveno RA, 2018, J PEDIAT-BRAZIL, V94, P539, DOI 10.1016/j.jped.2017.07.014
  2. Blay G, 2018, ADV RHEUMATOL, V58, DOI 10.1186/s42358-018-0038-4
  3. Brunelli JB, 2018, MOD RHEUMATOL, V28, P264, DOI 10.1080/14397595.2017.1349059
  4. Passone CGB, 2020, REV PAUL PEDIATR, V38, DOI 10.1590/1984-0462/2020/38/2018101
  5. Cardoso MP, 2006, PEDIATR CRIT CARE ME, V7, P423, DOI 10.1097/01.PCC.0000235257.86519.16
  6. Carlotti APCP, 2016, AM J CLIN PATHOL, V146, P701, DOI [10.1093/AJCP/AQW187, 10.1093/ajcp/aqw187]
  7. Chamseddine S, 2020, PLOS ONE, V15, DOI 10.1371/journal.pone.0239258
  8. Cifra CL, 2015, PEDIATR CRIT CARE ME, V16, P468, DOI 10.1097/PCC.0000000000000398
  9. Custer JW, 2015, PEDIATR CRIT CARE ME, V16, P29, DOI 10.1097/PCC.0000000000000274
  10. Santos ACEZ, 2019, REV INST MED TROP SP, V61, DOI [10.1590/S1678-9946201961039, 10.1590/s1678-9946201961039]
  11. Faco MMM, 2007, BRAZ J MED BIOL RES, V40, P993, DOI 10.1590/S0100-879X2006005000110
  12. GOLDMAN L, 1983, NEW ENGL J MED, V308, P1000, DOI 10.1056/NEJM198304283081704
  13. Hasan H, 2015, PATHOL RES PRACT, V211, P748, DOI 10.1016/j.prp.2015.06.008
  14. Kotovicz F, 2008, CLINICS, V63, P581, DOI 10.1590/S1807-59322008000500003
  15. Lucas SB, 2016, RECENT ADV HISTOPATH, V24, P25115
  16. Michaud PA, 2007, ADOLESCENT CHRONIC C, P1
  17. Ordi J, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0220657
  18. Parody R, 2015, BONE MARROW TRANSPL, V50, P274, DOI 10.1038/bmt.2014.229
  19. Presti Paula de Figueiredo, 2012, Rev. paul. pediatr., V30, P210
  20. Raghuram N, 2021, VIRCHOWS ARCH, V478, P1179, DOI 10.1007/s00428-020-03002-4
  21. Ramos GF, 2019, J PEDIAT-BRAZIL, V95, P667, DOI 10.1016/j.jped.2018.06.006
  22. Rodrigues FS, 2021, REV PAUL PEDIATR, V39, DOI 10.1590/1984-0462/2021/39/2019263
  23. Silva MF, 2015, J RHEUMATOL, V42, P2296, DOI 10.3899/jrheum.150142
  24. Tian N, 2015, EPILEPSY BEHAV, V45, P31, DOI 10.1016/j.yebeh.2015.02.006
  25. Vasquez-Hoyos P, 2022, J PEDIATR INTENSIVE, V11, P26, DOI 10.1055/s-0040-1719032
  26. Vinay K., 2018, ROBBINS BASIC PATHOL, V10th
  27. von Dessauer B, 2011, PEDIATR CRIT CARE ME, V12, P617, DOI 10.1097/PCC.0b013e3182071266

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/05
Artigos e Materiais de Revistas Científicas - LIM/06
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