Human Papillomavirus 16 Lineage A Variants Associated With Persistent Genital Infections in Men: The HPV Infection in Men (HIM) Study

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Citações na Scopus
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Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS INC
Autores
SIRAK, Bradley
LAZCANO-PONCE, Eduardo
NYITRAY, Alan G.
GIULIANO, Anna R.
Citação
JOURNAL OF INFECTIOUS DISEASES, v.228, n.12, p.1748-1757, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
We show for the first time the influence of human papillomavirus (HPV) 16 nucleotide variability on the risk of persistent infection in the male genitalia. Our data suggest differences in the natural history of HPV-16 variants between men and women. Background Human papillomavirus (HPV) 16 non-A lineage variants have higher carcinogenic potential for cervical cancer. HPV-16 variants natural history among males is not established. We evaluated HPV-16 variants prevalence and persistence in the external genitalia of men enrolled in the prospective HPV Infection in Men (HIM) Study. Methods The HIM Study included men from the United States, Brazil, and Mexico. HPV-16 variants were distinguished using polymerase chain reaction sequencing. The prevalence of HPV-16 variants was assessed, and associations with infection persistence were estimated. Results We characterized the HPV-16 variants for 1700 genital swab samples from 753 men and 22 external genital lesions in 17 men. The prevalence of HPV-16 lineages differed by country and marital status (P < .001). Overall, 90.9% of participants harbored lineage A variants. The prevalence of non-A lineages was heterogenous among countries. HPV-16 lineage A variants were associated with a 2.69-fold increased risk of long-term persistent infections compared with non-A lineages. All high-grade penile intraepithelial neoplasia harbored lineage A variants and occurred in the context of long-term persistent infections with the same variants. Conclusions The prevalence and persistence of HPV-16 variants observed at the male external genitalia suggest differences in the natural history of these variants between men and women, which may be associated with intrinsic differences in the infected genital epithelia.
Palavras-chave
genetic variants, genital, human papillomavirus, man, persistence
URI
https://observatorio.fm.usp.br/handle/OPI/57909
Referências
  1. Antaño-Arias R, 2021, PATHOGENS, V10, DOI 10.3390/pathogens10060773
  2. Berumen J, 2001, JNCI-J NATL CANCER I, V93, P1325, DOI 10.1093/jnci/93.17.1325
  3. Brim H, 2021, GASTROENTEROLOGY, V160, P922, DOI 10.1053/j.gastro.2020.10.022
  4. Chatterjee S, 2019, J VIROL, V93, DOI 10.1128/JVI.00915-19
  5. Chen ZG, 2005, J VIROL, V79, P7014, DOI 10.1128/JVI.79.11.7014-7023.2005
  6. Ferreira MT, 2021, VIROLOGY, V558, P134, DOI 10.1016/j.virol.2021.03.007
  7. Giuliano AR, 2008, CANCER EPIDEM BIOMAR, V17, P2036, DOI 10.1158/1055-9965.EPI-08-0151
  8. Giuliano AR, 2011, LANCET, V377, P932, DOI 10.1016/S0140-6736(10)62342-2
  9. Gonçalves MG, 2022, J CLIN VIROL, V149, DOI 10.1016/j.jcv.2022.105128
  10. Hildesheim A, 2001, BRIT J CANCER, V84, P1219, DOI 10.1054/bjoc.2001.1779
  11. HO L, 1993, J VIROL, V67, P6413, DOI 10.1128/JVI.67.11.6413-6423.1993
  12. Lou H, 2020, CANCER RES, V80, P3803, DOI 10.1158/0008-5472.CAN-20-0029
  13. Mirabello L, 2016, JNCI-J NATL CANCER I, V108, DOI 10.1093/jnci/djw100
  14. Nicolás-Párraga S, 2016, CANCER MED-US, V5, P2909, DOI 10.1002/cam4.870
  15. Nyitray AG, 2009, AM J EPIDEMIOL, V170, P965, DOI 10.1093/aje/kwp225
  16. Rositch AF, 2013, INT J CANCER, V133, P1271, DOI 10.1002/ijc.27828
  17. Schiffman M, 2010, CANCER RES, V70, P3159, DOI 10.1158/0008-5472.CAN-09-4179
  18. Serrano B, 2018, BEST PRACT RES CL OB, V47, P14, DOI 10.1016/j.bpobgyn.2017.08.006
  19. Sichero L, 2007, INT J CANCER, V120, P1763, DOI 10.1002/ijc.22481
  20. Smith B, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0021375
  21. Sudenga SL, 2016, EUR UROL, V69, P166, DOI 10.1016/j.eururo.2015.05.032
  22. Van Doorslaer K, 2017, NUCLEIC ACIDS RES, V45, pD499, DOI 10.1093/nar/gkw879
  23. Villa LL, 2000, J GEN VIROL, V81, P2959, DOI 10.1099/0022-1317-81-12-2959
  24. Xi LF, 1998, CANCER RES, V58, P3839
  25. Xi LF, 2007, CANCER EPIDEM BIOMAR, V16, P4, DOI 10.1158/1055-9965.EPI-06-0670
  26. Yamada T, 1997, J VIROL, V71, P2463, DOI 10.1128/JVI.71.3.2463-2472.1997

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03