LIM/17 - Laboratório de Investigação em Reumatologia
URI Permanente desta comunidade
O Laboratório de Investigação em Reumatologia é ligado ao Departamento de Clínica Médica da Faculdade de Medicina da Universidade de São Paulo (FMUSP).
Linhas de pesquisa: autoimunidade e doenças reumatológicas; clínica, diagnóstico, coinfecção e tratamento da doença de Lyme no Brasil; matriz extracelular nas doenças difusas do tecido conjuntivo; modelo experimental de artrose e esclerodermia; fisiopatologia da resposta inflamatória; terapêutica nas artrites inflamatórias crônicas; osteoporose e doenças reumatológicas; biologia molecular e celular aplicada a doenças osteometabólicas; LES, vasculites e doença de Takayasu; medicina esportiva, coluna e doenças reumatológicas.
Site oficial:Site oficial: http://limhc.fm.usp.br/portal/lim17-laboratorio-de-investigacao-em-reumatologia/
Linhas de pesquisa: autoimunidade e doenças reumatológicas; clínica, diagnóstico, coinfecção e tratamento da doença de Lyme no Brasil; matriz extracelular nas doenças difusas do tecido conjuntivo; modelo experimental de artrose e esclerodermia; fisiopatologia da resposta inflamatória; terapêutica nas artrites inflamatórias crônicas; osteoporose e doenças reumatológicas; biologia molecular e celular aplicada a doenças osteometabólicas; LES, vasculites e doença de Takayasu; medicina esportiva, coluna e doenças reumatológicas.
Site oficial:Site oficial: http://limhc.fm.usp.br/portal/lim17-laboratorio-de-investigacao-em-reumatologia/
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- LIM/17 - Laboratório de Investigação em Reumatologia
- LIM/17 - Laboratório de Investigação em Reumatologia
- LIM/17 - Laboratório de Investigação em Reumatologia
Submissões Recentes
Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic
(2024) RITTO, Ana Paula; ARAUJO, Adriana Ladeira de; CARVALHO, Carlos Roberto Ribeiro de; SOUZA, Heraldo Possolo De; FAVARETTO, Patricia Manga e Silva; SABOYA, Vivian Renata Boldrim; GARCIA, Michelle Louvaes; KULIKOWSKI, Leslie Domenici; KALLAS, Esper Georges; PEREIRA, Antonio Jose Rodrigues; COBELLO JUNIOR, Vilson; SILVA, Katia Regina; ABDALLA, Eidi Raquel Franco; SEGURADO, Aluisio Augusto Cotrim; SABINO, Ester Cerdeira; RIBEIRO JUNIOR, Ulysses; FRANCISCO, Rossana Pulcineli Vieira; MIETHKE-MORAIS, Anna; LEVIN, Anna Sara Shafferman; SAWAMURA, Marcio Valente Yamada; FERREIRA, Juliana Carvalho; SILVA, Clovis Artur; MAUAD, Thais; GOUVEIA, Nelson da Cruz; LETAIF, Leila Suemi Harima; BEGO, Marco Antonio; BATTISTELLA, Linamara Rizzo; DUARTE, Alberto Jose da Silva; SEELAENDER, Marilia Cerqueira Leite; MARCHINI, Julio; FORLENZA, Orestes Vicente; ROCHA, Vanderson Geraldo; MENDES-CORREA, Maria Cassia; COSTA, Silvia Figueiredo; CERRI, Giovanni Guido; BONFA, Eloisa Silva Dutra de Oliveira; CHAMMAS, Roger; BARROS FILHO, Tarcisio Eloy Pessoa de; BUSATTO FILHO, Geraldo
Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration to enhance research quality and efficiency.Methods At the FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing and analyzing demographic data, COVID-related data and biological materials from over 4,500 patients with confirmed SARS-CoV-2 infection hospitalized from 2020 to 2022. This strategy was mainly planned in three areas: organizing a database with data from the hospitalizations; setting-up a multidisciplinary taskforce to conduct follow-up assessments after discharge; and organizing a biobank. Additionally, a COVID-19 curated collection was created within the institutional digital library of academic papers to map the research output.Results Over the course of the experience, the possible benefits and challenges of this type of research support approach were identified and discussed, leading to a set of recommended strategies to enhance collaboration within the research institution. Demographic and clinical data from COVID-19 hospitalizations were compiled in a database including adults and a minority of children and adolescents with laboratory confirmed COVID-19, covering 2020-2022, with approximately 350 fields per patient. To date, this database has been used in 16 published studies. Additionally, we assessed 700 adults 6 to 11 months after hospitalization through comprehensive, multidisciplinary in-person evaluations; this database, comprising around 2000 fields per subject, was used in 15 publications. Furthermore, thousands of blood samples collected during the acute phase and follow-up assessments remain stored for future investigations. To date, more than 3,700 aliquots have been used in ongoing research investigating various aspects of COVID-19. Lastly, the mapping of the overall research output revealed that between 2020 and 2022 our academic system produced 1,394 scientific articles on COVID-19.Discussion Research is a crucial component of an effective epidemic response, and the preparation process should include a well-defined plan for organizing and sharing resources. The initiatives described in the present paper were successful in our aim to foster large-scale research in our institution. Although a single model may not be appropriate for all contexts, cross-disciplinary collaboration and open data sharing should make health research systems more efficient to generate the best evidence.
Physically Inactive Undergraduate Students Exhibit More Symptoms of Anxiety, Depression, and Poor Quality of Life than Physically Active Students
(2023) SANTANA, E. E. S. D.; NEVES, L. M.; SOUZA, K. C. D.; MENDES, T. B.; ROSSI, F. E.; SILVA, A. A. D.; OLIVEIRA, R. D.; PERILHãO, M. S.; ROSCHEL, H.; GIL, S.
Background: The World Health Organization (WHO) recommends at least 150 min of moderate or vigorous activity (MVPA) per week for health benefits. However, meeting WHO guidelines for physical activity has been shown to be a great challenge for general populations and it may be even more difficult for undergraduate students due to elevated academic demand, thus negatively affecting general health status. Thus, this study investigated whether undergraduate students meeting WHO guidelines for physical activity show greater scores for symptoms of anxiety, depression, and poor quality of life than their counterparts not meeting guideline recommendations. Additionally, symptoms of anxiety, depression, and poor quality of life among academic areas were compared. Methods: This is a cross-sectional study. The participants were recruited through messaging apps or institutional e-mail. The participants filled out an online consent form, questionnaires to assess demographic and academic characteristics, the International Physical Activity Questionnaire, the Beck depression and anxiety inventory, and the short-form 36-item health survey questionnaire. The participants were classified as physically active (MVPA > 150 min/week) or inactive (MVPA < 150 min/week) according to WHO Guidelines. Results: A total of 371 individuals were included in the analysis. Physically inactive students demonstrated higher scores of depression (17.96 vs. 14.62; 95% CI: −5.81 to −0.86; p = 0.0083) than physically active ones. SF-36 analyses revealed that physically inactive students had lower values in mental (45.68 vs. 52.77; 95% CI: 2.10 to 12.06; p = 0.0054) and physical (59.37 vs. 67.14; 95% CI: 3.24 to 12.30; p = 0.0015) domains compared with physically active ones. As for SF-36 subscales, physically inactive students showed lower scores in function capacity (70.45 vs. 79.70; 95% CI: 4.27 to 14.49; p = 0.0003), mental health (45.57 vs. 55.60; 95% CI: 5.28 to 14.76; p < 0.0001), social aspects (48.91 vs. 57.69; 95%CI: 3.47 to 14.08; p = 0.0012), vitality (42.19 vs. 50.61; 95% CI: 3.47 to 13.35; p = 0.0009), pain (61.85 vs. 68.00; 95% CI: 1.27 to 11.02; p = 0.0135), and general health status (53.82 vs. 63.81; 95% CI: 5.21 to 14.75; p < 0.0001) than their physically active peers. Conclusions: The findings suggest that undergraduate students who do not meet WHO guidelines for physical activity display higher scores of anxiety, depression, and poor quality of life in comparison with their counterparts meeting physical activity guidelines. Collectively, these data suggest the need for academic institutions and policy makers to monitor and promote in-campus interventions to encourage physical activity.
Demographic, clinical, laboratory data, prognostic, and treatment features of patients with antisynthetase syndrome: An international, two-center cohort study
(2022) SILVA, L. M. B. Da; RATHORE, U.; AGARWAL, V.; GUPTA, L.; SHINJO, S. K.
Objectives: To compare clinical, demographic, laboratory data, prognostic and treatment characteristics of patients with antisynthetase syndrome (ASSD) treated in two different centers of India and Brazil. Patients and methods: This international, two-center, retro-prospective cohort study which was conducted at two tertiary rheumatology centers (one in Brazil and one in India) between January 2000 to January 2020 included a total of 115 patients with ASSD (21 males, 94 females; mean age; at disease diagnosis at 40.3; range, 18 to 80 years). Demographic, clinical and laboratory data of the patients were recorded. Clinical involvement was evaluated. Results: Of the patients, 81 were Brazilians and 34 were of Indian origin. The Indian group exhibited a greater delay in diagnosis after the onset of symptoms compared to Brazilian patients (12 vs. 6 months, respectively; p=0.026). Brazilian patients exhibited a significantly higher prevalence of joint and lung involvement, mechanic’s hands, and Raynaud’s phenomenon. Anti-Jo-1 was the most common autoantibodies in both groups. Systemic arterial hypertension, followed by diabetes mellitus were the most prevalent comorbidities. Concerning previously used drugs, the Indian patients had a larger group of patients treated with antimalarials, whereas the Brazilian group used more azathioprine and intravenous immunoglobulin. A higher proportion of Indian patients was treated with one immunosuppressive drug (70.6%), while the Brazilian group were often treated using two immunosuppressive drugs (33%). Comparison between the severity and prognosis showed that Brazilian group had a higher number of relapses, and during follow-up, the global mortality rates were similar in both groups (6.2% for Brazilian vs. 8.8% for Indian). Conclusion: Brazilian and Indian patients with ASSD have comparable epidemiological characteristics such as age at the time of disease diagnosis, and sex distribution, and autoantibodies. Diagnostic delay is seen in Indian patients, and Brazilians exhibit a higher prevalence of joint and lung involvement, mechanic’s hands, Raynaud’s phenomenon with a higher number of relapses, although the mortality rate seems to be similar in both groups.
Increased Prolonged Sitting in Patients with Rheumatoid Arthritis during the COVID-19 Pandemic: A Within-Subjects, Accelerometer-Based Study
(2023) PINTO, A. J.; REZENDE, D.; SIECZKOWSKA, S. M.; MEIRELES, K.; BONFIGLIOLI, K.; RIBEIRO, A. C. D. M.; BONFá, E.; OWEN, N.; DUNSTAN, D. W.; ROSCHEL, H.; GUALANO, B.
Background: Social distancing measures designed to contain the COVID-19 pandemic can restrict physical activity, a particular concern for high-risk patient groups. We assessed rheumatoid arthritis patients’ physical activity and sedentary behavior level, pain, fatigue, and health-related quality of life prior to and during the social distancing measures implemented in Sao Paulo, Brazil. Methods: Post-menopausal females diagnosed with rheumatoid arthritis were assessed before (from March 2018 to March 2020) and during (from 24 May to 7 July 2020) social distancing measures to contain COVID-19 pandemic, using a within-subjects, repeated-measure design. Physical activity and sedentary behavior were assessed using accelerometry (ActivPAL micro). Pain, fatigue, and health-related quality of life were assessed by questionnaires. Results: Mean age was 60.9 years and BMI was 29.5 Kg/m2. Disease activity ranged from remission to moderate activity. During social distancing, there were reductions in light-intensity activity (13.0% [−0.2 h/day, 95% CI: −0.4 to −0.04; p = 0.016]) and moderate-to-vigorous physical activity (38.8% [−4.5 min/day, 95% CI: −8.1 to −0.9; p = 0.015]), but not in standing time and sedentary time. However, time spent in prolonged bouts of sitting ≥30 min increased by 34% (1.0 h/day, 95% CI: 0.3 to 1.7; p = 0.006) and ≥60 min increased by 85% (1.0 h/day, 95% CI: 0.5 to 1.6). There were no changes in pain, fatigue, and health-related quality of life (all p > 0.050). Conclusions: Imposed social distancing measures to contain the COVID-19 outbreak were associated with decreased physical activity and increased prolonged sedentary behavior, but did not change clinical symptoms sitting among patients with rheumatoid arthritis.
REASONS FOR BREASTFEEDING AVOIDANCE: A MULTICENTER INSIGHT IN MOTHERS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
(2023) FODDAI, S. G.; RADIN, M.; SCHREIBER, K.; CECCHI, I.; SIGNORELLI, F.; JESUS, G. De; ASO, K.; KONO, M.; URBAN, M. L.; BACCO, B.; CASSARINO, S. Gallo; SARDO, L. Lo; ARBRILE, M.; BARINOTTI, A.; GOMEZ-GARCIA, I.; QUAGLIA, M. I.; TISSERA, Y.; AGUIRRE-ZAMORANO, M. A.; ALBA, P.; BENEDETTO, C.; ATSUMI, T.; AMENGUAL, O.; EMMI, G.; ANDRADE, D.; MAROZIO, L.; ROCCATELLO, D.; SCIASCIA, S.
EFFICACY OF UPADACITINIB IN PATIENTS WITH NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS IN EARLY VERSUS ESTABLISHED DISEASE
(2023) NAVARRO-COMPAN, V.; BOSCH, F. Van den; SAMPAIO-BARROS, P. D.; GANZ, F.; BILJAN, A.; DUAN, Y.; D'SILVA, K.; WUNG, P.; OSTOR, A.; RAMIRO, S.
LATIN-AMERICAN SYSTEMIC LUPUS ERYTHEMATOSUS CLUSTERS
(2023) QUINTANA, R.; NIETO, R.; GOMEZ-PUERTA, J. A.; HARVEY, G. B.; SCOLNIK, M.; MERAS, N.; OTADUY, C.; NOVATTI, E.; ARTURI, V.; SATTLER, M. E.; PONS-ESTEL, G.; LUCERO, L. Gonzalez; GRAGEDA, W. Patino; PEREZ, N.; PISONI, C.; MONTANDON, A. C. D. O. E. S.; MONTICIELO, O.; DUARTE, A.; RIBEIRO, F. Machado; YUKI, E. Figueiredo Neves; REIS NETO, E.; HERRERA, I. Guerra; MIMICA, M.; MARTINEZ, G. Aroca; TOBON, G. J.; LOPEZ, G. Quintana; BONFANTI, A. Cadena; ALVAREZ, M. J. Moreno; SAAVEDRA, M. A.; PORTELA, M.; LOYO, H. Fragoso; TORRE, L. H. Silveira; VALLADARES, J. I. Garcia; ABUD-MENDOZA, C.; VALERIO, J. A. Esquivel; MARTINEZ, M.; DUARTE, M.; MORA, C.; UGARTE-GIL, M. F.; ZAVALA, E.; LOUIS, R. Munoz; ROBAINA, R.; JUAREZ, V.; SILVEIRA, G.; BORBA, E.; CATOGGIO, L.; ALARCON, G. S.; ZAZZETTI, F.; ORILLION, A.; SBARIGIA, U.; PONS-ESTEL, B.
RNA-SEQUENCING OF CLASSICAL MONOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS WITH AND WITHOUT BONE EROSION
(2023) SALES, L. Peixoto; HOUNKPE, B.; PEREZ, M.; CAPARBO, V.; DOMICIANO, D. S.; BORBA, E.; FIGUEIREDO, C.; PEREIRA, R. M.
THE CORRELATION BETWEEN URIC ACID AND BONE MINERAL DENSITY OF TOTAL HIP WITH BONE MICROARCHITECTURE ANALYSIS IN TOPHACEOUS GOUT PATIENTS
(2023) SANTOS, J. Barco Dos; ROCHA, G.; SALES, L. Peixoto; FRANCO, A. Silva; CAPARBO, V.; DOMICIANO, D.; FULLER, R.; FIGUEIREDO, C.; PEREIRA, R. M.
Performance of FRAX® Brazil and NOGG Methodology with and Without Bone Mineral Density upon Predicting Fractures on a Community-Dwelling Elderly Population with High Incidence of Osteoporotic Fractures - The Sao Paulo Ageing and Health (SPAH) Study
(2023) FREITAS, Thiago Q.; OLALLA, Leonardo F. Guerron; TAKAYAMA, Liliam; CAPARBO, Valeria F.; FIGUEIREDO, Camille P.; MACHADO, Luana G.; DOMICIANO, Diogo S.; PEREIRA, Rosa M. R.