MARIA BERNADETE DUTRA DE RESENDE
Índice h a partir de 2011
8
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
7 resultados
Resultados de Busca
Agora exibindo 1 - 7 de 7
- Motor function measure scale, steroid therapy and patients with Duchenne muscular dystrophy(2012) SILVA, Elaine C. da; MACHADO, Darlene L.; RESENDE, Maria B. D.; SILVA, Renata F.; ZANOTELI, Edmar; REED, Umbertina C.Objective: To assess the evolution of motor function in patients with Duchenne muscular dystrophy (DMD) treated with steroids (prednisolone or deflazacort) through the Motor Function Measure (MFM), which evaluates three dimensions of motor performance (D1, D2, D3). Methods: Thirty-three patients with DMD (22 ambulant, 6 non-ambulant and 5 who lost the capacity to walk during the period of the study) were assessed using the MFM scale six times over a period of 18 months. Results: All the motor functions remained stable for 14 months in all patients, except D1 for those who lost their walking ability. In ambulant patients, D2 (axial and proximal motor capacities) motor functions improved during six months; an improvement in D3 (distal motor capacity) was noted during the total follow-up. D1 (standing posture and transfers) and total score were useful to predict the loss of the ability to walk. Conclusions: The use of the MFM in DMD patients confirms the benefits of the steroid treatment for slowing the progression of the disease.
- Brazilian consensus on Duchenne muscular dystrophy. Part 1: diagnosis, steroid therapy and perspectives(2017) ARAUJO, Alexandra P. Q. C.; CARVALHO, Alzira A. S. de; CAVALCANTI, Eduardo B. U.; SAUTE, Jonas Alex M.; CARVALHO, Elmano; FRANCA JUNIOR, Marcondes C.; MARTINEZ, Alberto R. M.; NAVARRO, Monica de M. M.; NUCCI, Anamarli; RESENDE, Maria Bernadete D. de; GONCALVES, Marcus Vinicius M.; GURGEL-GIANNETTI, Juliana; SCOLA, Rosana H.; SOBREIRA, Claudia F. da R.; REED, Umbertina C.; ZANOTELI, EdmarSignificant advances in the understanding and management of Duchenne muscular dystrophy (DMD) took place since international guidelines were published in 2010. Our objective was to provide an evidence-based national consensus statement for multidisciplinary care of DMD in Brazil. A combination of the Delphi technique with a systematic review of studies from 2010 to 2016 was employed to classify evidence levels and grade of recommendations. Our recommendations were divided in two parts. We present Part 1 here, where we describe the guideline methodology and overall disease concepts, and also provide recommendations on diagnosis, steroid therapy and new drug treatment perspectives for DMD. The main recommendations: 1) genetic testing in diagnostic suspicious cases should be the first line for diagnostic confirmation; 2) patients diagnosed with DMD should have steroids prescribed; 3) lack of published results for phase 3 clinical trials hinders, for now, the recommendation to use exon skipping or read-through agents.
- Translation and validation of the Life Satisfaction Index for Adolescents scale with neuromuscular disorders: LSI-A Brazil(2017) SIMON, Valdecir Antonio; ZANOTELI, Edmar; SIMON, Margarete Andreozzi Vaz Pereira; RESENDE, Maria Bernadete Dutra de; REED, Umbertina ContiObjective: To validate the Life Satisfaction Index for Adolescents (LSI-A) scale, parent version and patient version, for Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA) and limb-girdle muscular dystrophy (LGMD). Methods: The parent version of the instrument was divided into Groups A, B, C and D; and the patient version, divided into B, C and D. For the statistical calculation, the following tests were used: Cronbach's alpha,ICC, Pearson and the ROC Curve. Results: The parent and patient versions of the instrument are presented, with the following results in the overall score, respectively: Cronbach's a, 0.87 and 0.89; reliability, r 0.98 and 0.97; reproducibility, ICC 0.69 and 0.80; sensitivity, 0.78 and 0.72; specificity, 0.5 and 0.69; and accuracy, 64% and 70.4%. Conclusion: According to the validity and reproducibility values, the LSI-A Brazil parent and patient versions, are clinically useful to assess quality of life in DMD, SMA or LGMD and may also be useful for other neuromuscular disorders.
- Quantitative Myasthenia Gravis Score: a Brazilian multicenter study for translation, cultural adaptation and validation(2017) OLIVEIRA, Ezequiel Fernandes; VALERIO, Berenice Cataldo Oliveira; CAVALCANTE, Valeria; URBANO, Jessica Julioti; SILVA, Anderson Soares; POLARO, Melissa Nunes; NACIF, Sergio Roberto; OLIVEIRA, Claudia Santos; RESENDES, Maria Bemadete Dutra; OLIVEIRA, Acary Souza Butte; OLIVEIRA, Luis Vicente FrancoObjective: To perform the translation, cross-cultural adaptation and validation of the Quantitative Myasthenia Gravis Score (QMGS) to Brazilian Portuguese in accordance with international ethical standards. Methods: The following steps were taken: (1) implementation of the translation protocol and transcultural adaptation, (2) validation of the adapted content, and (3) assessment of reliability.To check intraand inter-observer reproducibility, each patient underwent two interviews with interviewer-A and one with B. The QMGS was compared to the Myasthenia Gravis Composite Scale and Myasthenia-specific Quality of Life Questionnaire. Results: Our study group consisted of 30 patients, with a mean age of 47.6 +/- 11.4 years and a mean duration of illness of 11.33 +/- 8.49 years. Correlation between the QMGS and MGC was very strong (r = 0.928; p < 0.001) and substantial between the QMGS and MG-QOL 15 (r = 0.737; p < 0.001). Conclusion: The Brazilian Portuguese translation, and validation of the QMGS was successfully performed.
- Duchenne muscular dystrophy and Duane's syndrome: a rare association(2013) PASQUALIN, Livia M. A.; ZANOTELI, Edmar; VELOSO, Marco A. M.; FRIZZO, Silvana K.; RESENDE, Maria B. D.; ABUCHAM-NETO, Julio Z.; POLATI, Mariza; CHADI, Gerson; REED, Umbertina C.
- Compensatory movements during functional activities in ambulatory children with Duchenne muscular dystrophy(2014) MARTINI, Joyce; VOOS, Mariana Callil; HUKUDA, Michele Emy; RESENDE, Maria Bernadete Dutra de; CAROMANO, Fatima AparecidaObjective: During the transitional phase (ambulatory to non-ambulatory), synergies characterize the evolution of Duchenne muscular dystrophy (DMD). This study was performed to describe and quantify compensatory movements while sitting down on/rising from the floor and climbing up/down steps. Method: Eighty videos (5 children x 4 assessments x 4 tasks) were recorded quarterly in the year prior to gait loss. Compensatory movements from the videos were registered based on the Functional Evaluation Scale for DMD. Results: The most frequently observed compensatory movements were upper limb support on lower limbs/floor/handrail during all the tasks and lumbar hyperlordosis, trunk support on handrail, equinus foot, increased base of support, non-alternated descent, and pauses while climbing up/down steps. Conclusion: Climbing up/down steps showed a higher number of compensatory movements than sitting down on/rising from the floor, which seemed to be lost before climbing up/down steps in ambulatory children with DMD.
- Is functional dependence of Duchenne muscular dystrophy patients determinant of the quality of life and burden of their caregivers?(2015) MOURA, Maria Clara Drummond Soares de; WUTZKI, Hanna Camila; VOOS, Mariana Callil; RESENDE, Maria Bernadete Dutra; REED, Umbertina Conti; HASUE, Renata HydeeObjective: The relationship between functional dependence and quality of life (QOL) in Duchenne muscular dystrophy (DMD) patients and burden and QOL in caregivers is not clear. This study investigated possible relationships between functional dependence/QOL of DMD patients and QOL/burden of caregivers. Method: This study included 35 boys (6-17 years) and respective caregivers (above 21 years). Caregivers answered to World Health Organization Quality of Life and Zarit Burden Interview questionnaires. Patients were assessed with the Motor Function Measure and the Autoquestionnaire Qualite de vie Enfant Image. Spearman correlations and linear regressions were run to investigate relationships between the variables. Results: The occurrence of lower QOL and higher burden among the caregivers of patients with Duchenne muscular dystrophy was evidenced. The functional dependence of patients was not considered a determinant factor. Higher caregivers' burden was related to lower caregivers' QOL and to higher patients' ages.