BRUNO DO NASCIMENTO CARVALHO
Projetos de Pesquisa
Unidades Organizacionais
LIM/59 - Laboratório de Biologia Celular, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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conferenceObject Treatment with empagliflozin improves cardiac function in infarcted animals associated with increased baroreflex sensitivity(2023) SILVA, B. Da; NASCIMENTO-CARVALHO, B.; SOUZA, L. I. De; SILVA, M. B. Da; MARQUES, J. R.; DOURADO, P. M. M.; CONSOLIM-COLOMBO, F.; IRIGOYEN, M. C. C.- Combined Exercise Training Promotes More Benefits on Cardiovascular Autonomic Modulation in Ovariectomized Rats Than Isolated Aerobic or Resistance Training(2023) COSTA-SANTOS, Nicolas Da; COSTA, Gabrielly Minguta Santos; DOS-SANTOS, Adriano; NASCIMENTO-CARVALHO, Bruno; RIBEIRO, Thayna Fabiana; FREITAS, Sarah Cristina Ferreira; CAPERUTO, Erico; IRIGOYEN, Maria -Claudia; ANGELIS, Katia De; SCAPINI, Katia Bilhar; SANCHES, Iris CalladoIntroduction: Cardiovascular risk increase after ovarian deprivation has been extensively demonstrated by our research group through cardiovascular autonomic analysis. Interventions involving different types of exercises, such as resistance exercises or combined exercises (aerobic and resistance) have been widely recommended to prevent or minimize neuromuscular decline in postmenopausal women, which is aggravated by a sedentary lifestyle. Experimentally, the cardiovascular effects of resistance or combined training, as well as comparison between aerobic, resistance, and combined training, in ovariectomized animals are scarce. Purpose: In this study, we hypothesized that the combination of aerobic and resistance training may be more effective in preventing muscle mass loss, as well as improving cardiovascular autonomic modulation and baroreflex sensitivity, than aerobic or resistance training individually in ovariectomized rats. Animals and Methods: Female rats were divided into 5 groups: sedentary (C); ovariectomized (Ovx); trained ovariectomized submitted to aerobic training (OvxAT); resistance training (OvxRT); combined training (OvxCT). Exercise training lasted 8 weeks, with the combined group alternating between aerobic training and resistance training every other day. At the end of the study, glycemia and insulin tolerance were evaluated. Arterial pressure (AP) was directly recorded. Baroreflex sensitivity was assessed by heart rate response to changes in arterial pressure. Cardiovascular autonomic modulation was evaluated by spectral analysis. Results: Combined training was the only training regime that increased baroreflex sensitivity for tachycardic response and reduced all systolic blood pressure variability parameters. Furthermore, all animals submitted to exercise training on a treadmill (OvxAT and OvxCT) presented lower systolic, diastolic, and mean pressure, as well as improvements in the autonomic modulation for the heart. Conclusion: Combined training showed to be more effective than isolated aerobic and resistance training, mixing the isolated benefits of each modality. It was the only modality able to increase baroreflex sensitivity to tachycardic responses, reduce arterial pressure and all parameters of vascular sympathetic modulation.
- Food readjustment plus exercise training improves cardiovascular autonomic control and baroreflex sensitivity in high-fat diet-fed ovariectomized mice(2023) NASCIMENTO-CARVALHO, Bruno; DOS-SANTOS, Adriano; COSTA-SANTOS, Nicolas Da; CARVALHO, Sabrina L.; MORAES, Oscar A. de; SANTOS, Camila P.; ANGELIS, Katia De; CAPERUTO, Erico C.; IRIGOYEN, Maria-Claudia; SCAPINI, Katia B.; SANCHES, Iris C.Despite consensus on the benefits of food readjustment and/or moderate-intensity continuous exercise in the treatment of cardiometabolic risk factors, there is little evidence of the association between these two cardiovascular risk management strategies after menopause. Thus, the objective of this study was to evaluate the effects of food readjustment and/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet-induced obesity. Forty C57BL/6J ovariectomized mice were divided into the following groups: high-fat diet-fed - 60% lipids throughout the protocol (HF), food readjustment - 60% lipids for 5 weeks, readjusted to 10% for the next 5 weeks (FR), high-fat diet-fed undergoing moderate-intensity exercise training (HFT), and food readjustment associated with moderate-intensity exercise training (FRT). Blood glucose evaluations and oral glucose tolerance tests were performed. Blood pressure was assessed by direct intra-arterial measurement. Baroreflex sensitivity was tested using heart rate phenylephrine and sodium nitroprusside induced blood pressure changes. Cardiovascular autonomic modulation was evaluated in time and frequency domains. Inflammatory profile was evaluated by IL-6, IL-10 cytokines, and TNF-alpha measurements. Only the exercise training associated with food readjustment strategy induced improved functional capacity, body composition, metabolic parameters, inflammatory profile, and resting bradycardia, while positively changing cardiovascular autonomic modulation and increasing baroreflex sensitivity. Our findings demonstrate that the association of these strategies seems to be effective in the management of cardiometabolic risk in a model of loss of ovarian function with diet-induced obesity.
conferenceObject EXERCISE TRAINING ASSOCIATED WITH DIETARY ADJUSTMENT INDUCES METABOLIC AND CARDIOVASCULAR BENEFITS IN HIGH-FAT-FED MENOPAUSE RATS(2019) SANTOS, Adriano dos; SANTOS, Nicolas da Costa; NASCIMENTO-CARVALHO, Bruno do; CARVALHO, Sabrina Leonardo; MELLO-SILVA, Fernanda Queiroz; STABILE, Gabriel Correia; IZAIAS, Joao Eduardo; IRIGOYEN, Maria-Claudia; ANGELIS, Katia De; SCAPINI, Katia Bilhar; SANCHES, Iris Callado- DIFFERENT VOLUMES OF EXERCISE TRAINING IN AN EXPERIMENTAL MODEL OF MENOPAUSE AND OBESITY: METABOLIC, HEMODYNAMIC AND AUTONOMIC EFFECTS(2020) SANTOS, Adriano dos; COSTA-SANTOS, Nicolas da; BATISTA, Thayna Ribeiro; JESUS, Ney de; IZAIAS, Joao; NASCIMENTO-CARVALHO, Bruno do; ANGELIS, Katia De; IRIGOYEN, Maria-Claudia Costa; CAPERUTO, Erico; SCAPINI, Katia; SANCHES, Iris
- Effects of Exercise Intensity on Cardiometabolic Parameters of Ovariectomized Obese Mice(2023) DOS-SANTOS, Adriano; CARVALHO, Bruno do Nascimento; COSTA-SANTOS, Nicolas Da; MELLO-SILVA, Fernanda Queiroz de; PEREIRA, Abel de Assis; JESUS, Ney Roberto de; ANGELIS, Katia De; IRIGOYEN, Maria Claudia; BERNARDES, Nathalia; CAPERUTO, Erico Chagas; SCAPINI, Katia Bilhar; SANCHES, Iris CalladoThe aim of this study was to compare the effects of continuous-moderate vs. high-intensity interval aerobic training on cardiovascular and metabolic parameters in ovariectomized high-fat-fed mice. C57BL/6 female ovariectomized were divided into four groups (n=8): low-fat-fed sedentary (SLF); high-fat-fed sedentary (SHF); high-fat-fed moderate-intensity continuous trained (MICT-HF); and high-fat-fed high-intensity interval aerobic trained (HIIT-HF). The high-fat diet lasted 10 weeks. Ovariectomy was performed in the fourth week. The exercise training was carried out in the last four weeks of protocol. Fasting glycemia, oral glucose tolerance, arterial pressure, baroreflex sensitivity, and cardiovascular autonomic modulation were evaluated. Moderate-intensity continuous training prevented the increase in arterial pressure and promoted a reduction in HR at rest, associated with an improvement in the sympathovagal balance in MICT-HF vs. SHF. The high-intensity interval training reduced blood glucose and glucose intolerance in HIIT-HF vs. SHF and MICT-HF. In addition, it improved sympathovagal balance in HIIT-HF vs. SHF. Moderate-intensity continuous training was more effective in promoting cardiovascular benefits, while high-intensity interval training was more effective in promoting metabolic benefits.