CARLOS ALBERTO ABUJABRA MEREGE FILHO
Projetos de Pesquisa
Unidades Organizacionais
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
14 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 14
- Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling (vol 69, pg 1675, 2020)(2021) DANTAS, Wagner S.; ROSCHEL, Hamilton; MURAI, Igor H.; GIL, Saulo; DAVULURI, Gangarao; AXELROD, Christopher L.; GHOSH, Sujoy; NEWMAN, Susan S.; ZHANG, Hui; SHINJO, Samuel K.; NEVES, Willian das; MEREGE-FILHO, Carlos; TEODORO, Walcy R.; CAPELOZZI, Vera L.; PEREIRA, Rosa Maria; BENATTI, Fabiana B.; SA-PINTO, Ana L. de; CLEVA, Roberto de; SANTO, Marco A.; KIRWAN, John P.; GUALANO, Bruno
conferenceObject Effects Of Exercise Training On Strength And Functionality In Obese Subjects Undergoing Bariatric Surgery: Preliminary Findings(2018) ROSCHEL, Hamilton; GIL, Saulo; DANTAS, Wagner S.; MURAI, Igor H.; MEREGE FILHO, Carlos; SANTO, Marco A.; CLEVA, Roberto; GUALANO, Bruno- Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function(2021) GIL, Saulo; PECANHA, Tiago; DANTAS, Wagner S.; MURAI, Igor Hisashi; MEREGE-FILHO, Carlos Alberto Abujabra; SA-PINTO, Ana Lucia de; PEREIRA, Rosa Maria Rodrigues; CLEVA, Roberto de; SANTO, Marco Aurelio; REZENDE, Diego Augusto Nunes; KIRWAN, John P.; GUALANO, Bruno; ROSCHEL, HamiltonBackground Bariatric surgery improves cardiovascular health, which might be partly ascribed to beneficial alterations in the autonomic nervous system. However, it is currently unknown whether benefits from surgery on cardiac autonomic regulation in post-bariatric patients can be further improved by adjuvant therapies, namely exercise. We investigated the effects of a 6-month exercise training program on cardiac autonomic responses in women undergoing bariatric surgery. Methods Sixty-two women eligible for bariatric surgery were randomly allocated to either standard of care (control) or an exercise training intervention. At baseline (PRE) and 3 (POST3) and 9 (POST9) months after surgery, we assessed chronotropic response to exercise (CR%; i.e., percentage change in heart rate from rest to peak exercise) and heart rate recovery (HRR30s, HRR60s, and HRR120s; i.e., decay of heart rate at 30, 60, and 120 s post exercise) after a maximal exercise test. Results Between-group absolute changes revealed higher CR% (Delta = 8.56%, CI95% 0.22-19.90, P = 0.04), HRR30s (Delta = 12.98 beat/min, CI95% 4.29-21.67, P = 0.01), HRR60s (Delta = 22.95 beat/min, CI95% 11.72-34.18, P = 0.01), and HRR120s (Delta = 34.54 beat/min, CI95% 19.91-49.17, P < 0.01) in the exercised vs. non-exercised group. Conclusions Our findings demonstrate that exercise training enhanced the benefits of bariatric surgery on cardiac autonomic regulation. These results highlight the relevance of exercise training as a treatment for post-bariatric patients, ensuring optimal cardiovascular outcomes.
- Acute Effects of Resistance and Functional-Task Exercises on Executive Function of Obese Older Adults: Two Counterbalanced, Crossover, Randomized Exploratory Studies(2021) ALMEIDA, Stephany Silva de; TEIXEIRA, Emerson Luiz; MEREGE-FILHO, Carlos Alberto Abujabra; BRUCKI, Sonia Maria Dozzi; PAINELLI, Vitor de SallesWe explored the acute effect of different intensities of resistance exercise (RE: Study A) or functional-task exercise (FE; Study B) on cognitive function of obese older adults. In Study A, 15 obese older adults (age: 67 +/- 4 years; height: 1.61 +/- 0.05 m; body mass: 91.8 +/- 18.9 kg; body mass index: 35.3 +/- 7.1 kg/m(2); waist-hip ratio: 1.00 +/- 0.08) were submitted, in a counterbalanced, crossover, randomized fashion, to three conditions: (a) RE at 50% one-repetition maximum, (b) RE at 70% one-repetition maximum, and (c) control (CON, no exercise). In a similar design. in Study B, 16 obese older women (age: 65 +/- 2 years; height: 1.62 +/- 0.02 m; body mass: 94.0 +/- 8.8 kg; body mass index: 35.5 +/- 3.6 kg/m(2); waist-hip ratio: 0.97 +/- 0.04) were submitted to (a) FE and (b) CON. At pre- and postconditions, cognitive function was measured by the Stoop Test (ST, Parts A, B. and C) and the Trail Making Test (TMT, Parts A and B). In Study A, independent of intensity, RE significantly decreased time to complete the TMT-B, ST-B, and ST-C (all p < .05). whereas performance in CON was unchanged (all p > .05). Similar results were demonstrated in Study B. where time to complete TMT-A, TMT-B, ST-A. ST-B, and ST-C significantly reduced with FE (all p < .05), but not in CON (all p > .05). Both FE and RE acutely improved executive functions. Such positive effect seems to be independent of task, intensity, and executive function.
- INFLUENCE OF PHYSICAL EXERCISE ON COGNITION: AN UPDATE ON PHYSIOLOGICAL MECHANISMS(2014) MEREGE FILHO, Carlos Alberto Abujabra; ALVES, Christiano Robles Rodrigues; SEPULVEDA, Carlos Andres; COSTA, Andre dos Santos; LANCHA JUNIOR, Antonio Herbert; GUALANO, BrunoAlthough a growing body of literature has supported the beneficial role of exercise on cognition, there is no consensus on the mechanisms underlying acute and chronic cerebral adaptations to exercise. The present review aims to present and discuss the mechanisms by which exercise affects cognitive performance. It has been speculated that the acute effects of exercise on cognitive response may be mediated by increases in cerebral blood flow and, hence, in nutrient availability, or by increases in neurotransmitter activity. It has been also postulated that chronic exercise may induce adaptations in brain structures and the synaptic plasticity, which would result in cognitive improvements. These hypotheses are discussed in light of available scientific evidence in animal models and humans
- Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial(2023) MEREGE-FILHO, Carlos A. A.; GIL, Saulo S.; KIRWAN, John P.; MURAI, Igor H.; DANTAS, Wagner S.; NUCCI, Mariana P.; PASTORELLO, Bruno; LIMA, Alisson Padilha de; BAZAN, Paulo R.; PEREIRA, Rosa M. R.; SA-PINTO, Ana L. de; LIMA, Fernanda R.; BRUCKI, Sonia M. D.; CLEVA, Roberto de; SANTO, Marco A.; LEITE, Claudia da Costa; OTADUY, Maria Concepcion Garcia; ROSCHEL, Hamilton; GUALANO, BrunoBackgroundObesity is a disease that may involve disrupted connectivity of brain networks. Bariatric surgery is an effective treatment for obesity, and the positive effects on obesity-related conditions may be enhanced by exercise. Herein, we aimed to investigate the possible synergistic effects of Roux-en-Y Gastric Bypass (RYGB) and exercise training on brain functional networks. MethodsThirty women eligible for bariatric surgery were randomly assigned to a Roux-en-Y gastric bypass (RYGB: n = 15, age = 41.0 & PLUSMN; 7.3 years) or RYGB plus Exercise Training (RYGB + ET: n = 15, age = 41.9 & PLUSMN; 7.2 years). Clinical, laboratory, and brain functional connectivity parameters were assessed at baseline, and 3 (POST3) and 9 months (POST9) after surgery. The 6-month, three-times-a-week, exercise intervention (resistance plus aerobic exercise) was initiated 3 months post-surgery (for RYGB + ET). ResultsExercise superimposed on bariatric surgery (RYGB + ET) increased connectivity between hypothalamus and sensorial regions (seed-to-voxel analyses of hypothalamic connectivity), and decreased default mode network (DMN) and posterior salience (pSAL) network connectivity (ROI-to-ROI analyses of brain networks connectivity) when compared to RYGB alone (all p-FDR < 0.05). Increases in basal ganglia (BG) network connectivity were only observed in the exercised training group (within-group analyses). ConclusionExercise training is an important component in the management of post-bariatric patients and may improve the hypothalamic connectivity and brain functional networks that are involved in controlling food intake.
- Efeito da suplementação de creatina, associada ou não ao treinamento de força, sobre a peroxidação lipídica em mulheres idosas(2014) ALVES, Christiano Robles Rodrigues; MEREGE FILHO, Carlos Alberto Abujabra; JANNING, Paulo Roberto; BECHARA, Luiz Roberto Grassmann; AZEVEDO, Rafael de Almeida; BENATTI, Fabiana Braga; PEREIRA, Rosa Maria Rodrigues; PINTO, Ana Lúcia de Sá; BRUM, Patrícia Chakur; GUALANO, BrunoThe aim of this study was to evaluate the effects of creatine supplementation associated or not with strength training upon lipid peroxidation in older women. This was a clinical, randomized, double-blind, placebo-controlled trial. Older women were randomly allocated into four groups: 1) placebo supplementation (PL, n = 10), 2) creatine supplementation (CR; n = 10), 3) placebo supplementation associated with strength training (PL + RT, n = 6) and 4) creatine supplementation associated with strength training (CR + RT, n = 8). Before (PRE) and after 24 weeks (POST), blood samples were collected to measure lipid hydroperoxides concentration by spectrophotometry. No statistical difference was observed on the lipid hydroperoxides concentration between groups (PL: PRE = 48.7 ± 36.9; POST = 29.3 ± 18.8; Δ = -13.0 ± 26.8; CR : PRE = 51.0 ± 46.0; POST = 54.2 ± 51.6; Δ = -8.6 ± 30.2; + PL TR: PRE = 33.0 ± 11.2; POST = 47.3 ± 31.6, Δ = 14.3 ± 39.2; CR + TR: PRE = 18.5 ± 10.1; POST = 28.1 ± 17.9, Δ = 9.7 ± 16.4 pmol.mg-1 of total protein, p = 0.17). Creatine supplementation associated or not with strength training did not affect the lipid peroxidation, an important plasmatic marker of oxidative stress, in elderly women.
- Reversal of Improved Endothelial Function After Bariatric Surgery Is Mitigated by Exercise Training(2018) DANTAS, Wagner Silva; GIL, Saulo; MURAI, Igor Hisashi; COSTA-HONG, Valeria; PECANHA, Tiago; MEREGE-FILHO, Carlos Alberto Abujabra; SA-PINTO, Ana Lucia de; CLEVA, Roberto de; SANTO, Marco Aurelio; PEREIRA, Rosa Maria Rodrigues; KIRWAN, John P.; ROSCHEL, Hamilton; GUALANO, Bruno
conferenceObject Exercise Suppresses The Ubiquitin-proteasome System In The Skeletal Muscle Of Obese Women Following Bariatric Surgery(2020) GIL, Saulo; GUALANO, Bruno; DANTAS, Wagner S.; MURAI, Igor H.; GHOSH, Sujoy; SHINJO, Samuel K.; MEREGE-FILHO, Carlos; TEODORO, Walcy R.; PEREIRA, Rosa Maria; BENATTI, Fabiana B.; SA-PINTO, Ana L. de; LIMA, Fernanda; CLEVA, Roberto de; SANTO, Marco A.; KIRWAN, John P.; ROSCHEL, HamiltonconferenceObject EXERCISE AS A TREATMENT TO ATTENUATE BONE LOSS IN WOMEN AFTER ROUX-EN-Y GASTRIC BY PASS : A RANDOMIZED CONTROLLED TRIAL(2019) MURAI, I. H.; ROSCHEL, H.; DANTAS, W. S.; GIL, S.; MEREGE-FILHO, C. A.; CAPARBO, V.; TAKAYAMA, L.; SA-PINTO, A. L.; CLEVA, R.; SANTO, M. A.; KIRWAN, J.; PEREIRA, R. M.; GUALANO, B.