KAUY VICTOR MARTINEZ FARIA
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/21 - Laboratório de Neuroimagem em Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
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Resultados de Busca
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conferenceObject SPORADIC PRIMARY HYPERPARATHYROIDISM AND STONE DISEASE: A COMPREHENSIVE METABOLIC EVALUATION BEFORE AND AFTER PARATHYROIDECTOMY(2018) MARCHINI, Giovanni; FARIA, Kauy; TORRICELLI, Fabio; MONGA, Manoj; VICENTINI, Fabio; DANILOVIC, Alexandre; SROUGI, Miguel; NAHAS, William; MAZZUCCHI, Eduardo- Understanding urologic scientific publication patterns and general public interests on stone disease: lessons learned from big data platforms(2021) MARCHINI, Giovanni S.; FARIA, Kauy V. M.; NETO, Felippe L.; TORRICELLI, Fabio Cesar Miranda; DANILOVIC, Alexandre; VICENTINI, Fabio Carvalho; BATAGELLO, Carlos A.; SROUGI, Miguel; NAHAS, William C.; MAZZUCCHI, EduardoPurpose To analyse patterns of stone disease online information-seeking behaviours in the United States and to correlate with urological literature publication aspects. Methods To compare Relative Search Volume (RSV) among different twelve preselected urologic keywords we chose ""United States"" as country and ""01/01/2009-31/12/2018"" as time range on Google Trends (GT). We defined ""ureteroscopy"" as a reference and compared RSV against it for each term. RSV was adjusted and normalized in a scale 0-100. Trend presence was evaluated by Mann-Kendall Test and magnitude by Sen's Slope Estimator (SS). Weather influence on RSV was also investigated by comparison of the ten hottest versus ten coldest states. Pearson correlation analysis was performed between number of Pubmed publications and RSV for each term over time. Results We found an upward tendency (p 0.01) for most terms. Higher temporal trends were seen for ""kidney stone"" (SS = 0.36), ""kidney pain"" (SS = 0.39) and ""tamsulosin"" (SS = 0.21). Technical treatment terms had little search volumes and no increasing trend. States with hotter weather showed higher mean RSV for ""kidney stone"" than colder ones. There was little correlation between GT and Pubmed for most terms, with the exception of ""kidney stone"" (R = 0.89; p 0.01), ""URS"" (R = 0.81; p 0.01), and ""laser lithotripsy"" (R = 0.74; p = 0.01). Conclusion There was a significant increase in online search for medical information related to stone disease. Citizens tend to look for generic terms related to symptoms or the disease itself. States with hotter weather show higher RSV than colder states. There is a discrepancy between public and medical community medical terms.
- Psychopharmacology and psychotherapy for the treatment of adults with ADHD-a systematic review of available meta-analyses(2013) MORIYAMA, Tais S.; POLANCZYK, Guilherme V.; TERZI, Fernanda S.; FARIA, Kauy M.; ROHDE, Luis A.Objective/Introduction Attention-deficit/hyperactivity disorder (ADHD) in adult life is a prevalent condition. We systematically reviewed the literature available by searching for meta-analyses assessing pharmacological and psychosocial interventions for adults with ADHD. Methods Using wide-ranging search terms, we retrieved 191 titles from the PubMed and Cochrane databases. Two independent evaluators judged all abstracts. Only meta-analyses about the treatment of adults with ADHD were included. Information from meta-analyses found was systematically extracted by 3 independent evaluators. Results Eight meta-analyses were identified. Results from those meta-analyses suggest that stimulants are effective in decreasing ADHD symptoms on a short-term basis with a medium to large effect size (ES). Short-acting stimulants might be superior to long-acting stimulants, but no data on difference in adherence are available for the comparison of these two types of formulation. Bupropion is superior to placebo but less effective than stimulants. No conclusions about the impact of psychosocial interventions can be drawn based on meta-analyses so far. Discussion The efficacy of stimulants in reducing ADHD symptoms for adults is well documented in meta-analyses, but there is a concerning lack of meta-analysis about other treatment interventions. Conclusion The available meta-analytic literature does not cover questions of essential clinical relevance for adults with ADHD.
bookPart 0 Citação(ões) na Scopus Integrating psychopharmacology and psychotherapy to treat children with ADHD(2013) MORIYAMA, T. S.; POLANCZYK, G. V.; TERZI, F. S.; FARIA, K. M.; DöPFNER, M.; ROHDE, L. A.- Therapeutic Approaches to Penile Cancer: Standards of Care and Recent Developments(2023) WHITE, Joshua; MASON, Ross; LAWEN, Tarek; SPOONER, Jesse; FARIA, Kauy V. M.; RAHMAN, Farah; RAMASAMY, RanjithPenile cancer is a rare malignancy, most commonly diagnosed in older men, associated with poor outcomes, dramatic decline in quality of life and sexual function. Squamous cell carcinoma is the most common histopathology of penile cancer, accounting for 95% of all cases. Localized, early-stage penile cancer can be effectively managed through penile-sparing techniques in many cases, though advanced stages of penile cancer carry a poor prognosis. Current innovative treatments are exploring the role of targeted therapy, HPV-directed therapy, immune checkpoint inhibitors and adoptive T-cell therapies in treatment and prevention of relapse of penile cancer. Clinical trials are investigating the potential of targeted therapies and immune checkpoint inhibitors in advanced penile cancer. This review examines the current management of penile cancer and highlights future directions in research and treatment.
- Comparing public interest on stone disease between developed and underdeveloped nations: are search patterns on google trends similar?(2021) MARCHINI, Giovanni S.; FARIA, Kauy V. M.; NETO, Felippe L.; TORRICELLI, Fabio Cesar Miranda; DANILOVIC, Alexandre; VICENTINI, Fabio Carvalho; BATAGELLO, Carlos A.; SROUGI, Miguel; NAHAS, Willaim C.; MAZZUCCHI, EduardoObjective: The big data provided by Google Trends may reveal patterns in health information-seeking behavior on population from Brazil and United States (US). Our objective was to explore and compare patterns of stone disease online information-seeking behaviors in both nations. Materials and Methods: To compare Relative Search Volume (RSV) among different urologic key words we chose ""US"" and ""Brazil"" as country and ""01/01/2009 - 31/12/2018"" as time-range. The final selection included 12 key words in each language. We defined ""ureteroscopy"" as a reference and compared RSV against it for each term. RSV was adjusted by the reference and normalized in a scale from 0-100. Trend presence was evaluated by Mann Kendall Test and magnitude by Sen's Slope (SS) Estimator. Results: We found an upward trend (p < 0.01) in most of the researched terms in both countries. Higher temporal trends were seen for ""Kidney Stone"" (SS=0.36), ""Kidney Pain"" (SS=0.39) and ""Tamsulosin"" (SS=0.21) in the US. Technical treatment terms had little search volumes and no increasing trend. ""Kidney Stent"" and ""Double J"" had a significant increase in search trend over time and had a relevant search volume overall in 2018. In Brazil, ""Calculo Renal"", ""Colica Renal"", ""Dor no Rim"" and ""Pedra no Rim"" had a significant increase in RSV (p < 0.001). More common and popular terms as ""Kidney Stent"" and ""Tamsulosin"" were highly correlated with ""Kidney Pain"" and ""Kidney Stone"" in both countries. Conclusions: In the last decade, there was a significant increase in online search for medical information related to stone-disease. Population from both countries tend to look more for generic terms related to symptoms, the disease, medical management and kidney stent, than for technical treatment vocabulary.
- Sporadic primary hyperparathyroidism and stone disease: a comprehensive metabolic evaluation before and after parathyroidectomy(2018) MARCHINI, Giovanni S.; FARIA, Kauy V. M.; TORRICELLI, Fabio C. M.; MONGA, Manoj; SROUGI, Miguel; NAHAS, William C.; MAZZUCCHI, EduardoObjectives To characterize the stone risk and the impact of parathyroidectomy on the metabolic profile of patients with primary hyperparathyroidism (PHPT) and urolithiasis. Patients and Methods We analysed the prospectively collected charts of patients treated at our stone clinic between January 2001 and January 2016 searching for patients with PHPT and urolithiasis. Imaging evaluation of the kidneys, bones and parathyroid glands was assessed. We analysed the demographic data, serum and urinary variables before and after parathyroidectomy. We used a paired t-test, Fisher's test, Spearman's test and ANOVA in the statistical analysis. Results A total of 51 patients were included. The mean patient age was 57.1 +/- 12.1 years and 82.4% were women. Before parathyroidectomy, mean calcium and parathyroid hormone (PTH) levels were 11.2 +/- 1.0 mg/dL and 331 +/- 584 pg/dL, respectively. Hypercalcaemia was present in 84.3% of patients. All eight patients with normal calcium levels had elevated PTH levels. Only two patients did not have PTH above the normal range, although both had elevated calcium levels. The most common urinary disorders were low urinary volume (64.7%), hypercalciuria (60.8%), high urinary pH (41.2%) and hypocitraturia (31.4%). After parathyroidectomy, the number of patients with hypercalcaemia (n = 4; 7.8%), elevated PTH (n = 17; 33.3%) and hypophosphataemia (n = 3; 5.9%) significantly decreased (P < 0.001). The number of urinary abnormalities decreased and there was a reduction in urinary calcium (P < 0.001), pH (P = 0.001) and citrate levels (P = 0.003). Conclusion Individuals with PHPT and nephrolithiasis frequently have elevated baseline PTH and calcium levels. Low volume, hypercalciuria, high urinary pH, and hypocitraturia are the most frequent urinary disorders. Parathyroidectomy is effective in normalizing serum calcium and PTH levels, although other urinary metabolic may persist. Patients should be monitored for the need for citrate supplementation.