LUIS FERNANDO HINDI BASILE
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/01 - Laboratório de Informática Médica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
LIM/01 - Laboratório de Informática Médica, Hospital das Clínicas, Faculdade de Medicina
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
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- Analysis of slow- and fast-alpha band asymmetry during performance of a saccadic eye movement task: Dissociation between memory- and attention-driven systems(2012) SANFIM, Antonio; VELASQUES, Bruna; MACHADO, Sergio; ARIAS-CARRION, Oscar; PAES, Flavia; TEIXEIRA, Silmar; SANTOS, Joana Luz; BITTENCOURT, Juliana; BASILE, Luis F.; CAGY, Mauricio; PIEDADE, Roberto; SACK, Alexander T.; NARDI, Antonio Egidio; RIBEIRO, PedroThis study aimed at analyzing the relationship between slow- and fast-alpha asymmetry within frontal cortex and the planning, execution and voluntary control of saccadic eye movements (SEM), and quantitative electroencephalography (qEEG) was recorded using a 20-channel EEG system in 12 healthy participants performing a fixed (i.e., memory-driven) and a random SEM (i.e., stimulus-driven) condition. We find main effects for SEM condition in slow- and fast-alpha asymmetry at electrodes F3-F4, which are located over premotor cortex, specifically a negative asymmetry between conditions. When analyzing electrodes F7-F8, which are located over prefrontal cortex, we found a main effect for condition in slow-alpha asymmetry, particularly a positive asymmetry between conditions. In conclusion, the present approach supports the association of slow- and fast-alpha bands with the planning and preparation of SEM, and the specific role of these sub-bands for both, the attention network and the coordination and integration of sensory information with a (oculo)-motor response.
article 19 Citação(ões) na Scopus Alzheimer's disease qEEG Spectral analysis versus coherence. Which is the best measurement?(2011) ANGHINAH, Renato; KANDA, Paulo Afonso Medeiros; LOPES, Helder Frederico; BASILE, Luis Fernando Hindi; MACHADO, Sergio; RIBEIRO, Pedro.; VELASQUES, Bruna; SAMESHIMA, Koichi; TAKAHASHI, Daniel Yasumasa; PINTO, Lecio Figueira; CARAMELLI, Paulo; NITRINI, RicardoThere is evidence in electroencephalography that alpha, theta and delta band oscillations reflect cognitive and memory performances and that quantitative techniques can improve the electroencephalogram (EEG) sensitivity. This paper presents the results of comparative analysis of qEEG variables as reliable markers for Alzheimer's disease (AD). We compared the sensitivity and specificity between spectral analysis (spectA) and coherence (Coh) within the same group of AD patients. SpectA and Coh were calculated from EEGs of 40 patients with mild to moderate AD and 40 healthy elderly controls. The peak of spectA was smaller in the AD group than in controls. AD group showed predominance of slow spectA in theta and delta bands and a significant reduction of inter-hemispheric Coh for occipital alpha 2 and beta 1 and for frontal delta sub-band. ROC curve supported that alpha band spectA was more sensitive than coherence to differentiate controls from AD.- Individual versus task differences in slow potential generators(2021) BASILE, Luis F. H.; SATO, Joao R.; PASQUINI, Henrique A.; VELASQUES, Bruna; RIBEIRO, Pedro; ANGHINAH, RenatoAverage slow potentials (SPs) can be computed from any voluntary task, minimally involving attention to anticipated stimuli. Their topography when recorded by large electrode arrays even during simple tasks is complex, multifocal, and its generators appear to be equally multifocal and highly variable across subjects. Various sources of noise of course contaminate such averages and must contribute to the topographic complexity. Here, we report a study in which the non-averaged SP band (0 to 1 Hz) was analyzed by independent components (ICA), from 256 channel recordings of 18 subjects, during four task conditions (resting, visual attention, CPT, and Stroop). We intended to verify whether the replicable SP generators (between two separate day sessions) modeled as current density reconstruction on structural MRI sets were individual-specific, and if putative task-related differences were systematic across subjects. Typically, 3 ICA components (out of 10) explained SPs in each task and subject, and their combined generators were highly variable across subjects: although some occipito-temporal and medial temporal areas contained generators in most subjects; the overall patterns were obviously variable, with no single area common to all 18 subjects. Linear regression modeling to compare combined generators (from all ICA components) between tasks and sessions showed significantly higher correlations between the four tasks than between sessions for each task. Moreover, it was clear that no common task-specific areas could be seen across subjects. Those results represent one more instance in which individual case analyses favor the hypothesis of individual-specific patterns of cortical activity, regardless of task conditions. We discuss this hypothesis with respect to results from the beta band, from individual-case fMRI studies, and its corroboration by functional neurosurgery and the neuropsychology of focal lesions.
- Integrative parietal cortex processes: Neurological and psychiatric aspects(2014) TEIXEIRA, Silmar; MACHADO, Sergio; VELASQUES, Bruna; SANFIM, Antonio; MINC, Daniel; PERESSUTTI, Caroline; BITTENCOURT, Juliana; BUDDE, Henning; CAGY, Mauricio; ANGHINAH, Renato; BASILE, Luis F.; PIEDADE, Roberto; RIBEIRO, Pedro; DINIZ, Claudia; CARTIER, Consuelo; GONGORA, Mariana; SILVA, Farmy; MANAIA, Femanda; SILVA, Julio GuilhermeFor many decades the parietal cortex (PC) has been considered the key area in tasks which involve the integration of different stimuli. PC is fundamental to determine spatial sense, information navigation and integration, and is involved in several aspects of the complex motor repertoire and in neurological and psychiatric disorders. In this review, we focus on seven different aspects of PC: (i) neuroanatomy of the parietal cortex; (ii) sensory motor integration processes; iii) hand movement control: reaching, grasping, and pointing; (iv) saccadic eye movements; (v) movement observation; (vi) neurological aspects: ataxia, autism and Parkinson's disease; and (vii) psychiatric aspects: schizophrenia, bipolar disorder and depression. Among these, we related the perspectives which involve the functions of the parietal cortex and mirror neurons and that seem to play a fundamental role in action prediction, planning, observation and execution. Furthermore, we focused on the relationship between posterior parietal cortex (PPC) and hand-guided movements. For this review, we conducted an academic paper search which fulfilled the objective of the study. We conclude that the PC has great participation in different motor functions and neurological/psychiatric disorders.
- Comparative analysis of the electroencephalogram in patients with Alzheimer's disease, diffuse axonal injury patients and healthy controls using LORETA analysis(2017) IANOF, Jéssica Natuline; FRAGA, Francisco José; FERREIRA, Leonardo Alves; RAMOS, Renato Teodoro; DEMARIO, José Luiz Carlos; BARATHO, Regina; BASILE, Luís Fernando Hindi; NITRINI, Ricardo; ANGHINAH, RenatoABSTRACT Alzheimer's disease (AD) is a dementia that affects a large contingent of the elderly population characterized by the presence of neurofibrillary tangles and senile plaques. Traumatic brain injury (TBI) is a non-degenerative injury caused by an external mechanical force. One of the main causes of TBI is diffuse axonal injury (DAI), promoted by acceleration-deceleration mechanisms. Objective: To understand the electroencephalographic differences in functional mechanisms between AD and DAI groups. Methods: The study included 20 subjects with AD, 19 with DAI and 17 healthy adults submitted to high resolution EEG with 128 channels. Cortical sources of EEG rhythms were estimated by exact low-resolution electromagnetic tomography (eLORETA) analysis. Results: The eLORETA analysis showed that, in comparison to the control (CTL) group, the AD group had increased theta activity in the parietal and frontal lobes and decreased alpha 2 activity in the parietal, frontal, limbic and occipital lobes. In comparison to the CTL group, the DAI group had increased theta activity in the limbic, occipital sublobar and temporal areas. Conclusion: The results suggest that individuals with AD and DAI have impairment of electrical activity in areas important for memory and learning.
article 3 Citação(ões) na Scopus Bromazepam Impairs Motor Response: An ERSP Study(2011) SILVA, Julio G.; ARIAS-CARRION, Oscar; PAES, Flavia; VELASQUES, Bruna; TEIXEIRA, Silmar; BASILE, Luis F. H.; CAGY, Mauricio; PIEDADE, Roberto; NARDI, Antonio E.; MACHADO, Sergio; RIBEIRO, PedroThis study aimed to investigate the acute modulatory effect of bromazepam, a benzodiazepine derivative drug, on alpha and beta bands (8-35Hz) in primary motor areas (M1) through event-related spectral perturbation (ERSP). Ten healthy subjects were submitted to a cross-over double-blind design. Subjects performed a visuomotor task where they had to identify rapidly the ball launched horizontally and catch it quickly, while electroencephalographic activity was acquired. We found a statistically significant difference on the time windows of 2920 ms for 13Hz in the electrodes C3 and Cz, and on the time window of 2000 ms for 18Hz in the electrodes C3, when compared the bromazepam and placebo conditions. We concluded that the acute effects of bromazepam provoked changes in information process in the left M1 represented by electrode C3 in both 13 Hz and 18 Hz. Our paradigm is relevant for a better understanding of the brain dynamics due to the information related to bromazepam effects on sensorimotor processes. We consider this report an invitation to conduct more studies in order to associate electro-cortical activity and psychometric tests.article 0 Citação(ões) na Scopus Neurophysiological changes after cognitive-motor tasks in Parkinson's disease patients with deep brain stimulation(2019) NEGRI, Mauricio; GONGORA, Mariana; NASSER, Jose Augusto; SALLES, Jose Inacio; TEIXEIRA, Silmar; ARIAS-CARRION, Oscar; JUNQUEIRA, Joao; NICOLICHE, Eduardo; VELASQUES, Bruna; CAGY, Mauricio; BUDDE, Henning; BASILE, Luis F.; ORSINI, Marco; FRIEDE, Roy; BASTOS, Victor Hugo; RIBEIRO, PedroChronic deep brain stimulation (CDBS) is a surgical treatment that reduces the cardinal signs of Parkinson's disease (PD). Although CDBS has been in use for a long time, very little has been reported on its supposed effects on cognition, particularly in relation to implants in the subthalamic nucleus. The results of the rare studies that do exist are controversial, and in many cases the studies have several design flaws. The present study compared cortical activation during three tasks (action execution, action observation and motor imagery) in PD patients with and without subthalamic implants. The study sample consisted of 36 volunteers, divided into three groups: healthy controls, PD patients with CDBS of the subthalamic nucleus, and PD patients without CDBS. Through a quantitative electroencephalogram assessment, absolute beta power was examined to observe the interaction between group and cognitive motor tasks. The electrodes at sites Fp1, Fp2, F7, F8, F3, Fz and F4, located in the prefrontal and frontal regions, were analyzed and a Group x Task interaction (p < 0.05) was observed for all of them. These findings suggest that CDBS of the subthalamic nucleus is efficient in reducing some of the effects of PD in these study tasks. At the same time, the dysfunctions found in several cortical areas, characteristic of PD, limited the effects of the CDBS. The results of this study suggest that CDBS of the subthalamic nucleus can modulate cognitive-motor aspects of PD.- Effects of functional electro-stimulation in the theta-band coherence: a quantitative electroencephalograph study(2011) SANTOS, Joana; VELASQUES, Bruna; PAES, Flavia; MACHADO, Sergio; ARIAS-CARRION, Oscar; CUNHA, Marlo; BUDDE, Henning; ANGHINAH, Renato; BASILE, Luis; CAGY, Mauricio; PIEDADE, Roberto; RIBEIRO, PedroIntroduction. Functional electrical stimulation (FES) is a technique used for rehabilitation of motor and sensory dysfunction and consisted in the application of neuromuscular electrical stimulation concurrently with a functional activity. Previous studies suggest that sensory motor processing during FES stimulation of hand is similar to that of voluntary hand movement. Aim. To examine the changes in theta band (4-8 Hz) coherence in the centro-parietal and temporo-parietal junction during a FES task. Our hypothesis is that different conditions of electro-stimulation can produce changes in the theta band coherence in the sensory-motor and multisensory integration. Subjects and methods. The sample was composed of 24 students, male (n=14) and female (n=10), between 25 and 40 years old. Subjects were randomly distributed in three groups: control group (n = 8), G24 (n = 8) and G36 (n = 8). The control group simulated four blocks without electrostimulation been applied. The G24 group was exposed to four blocks of electrostimulation. The G36 group was exposed to six blocks of electrostimulation. We employed FES equipment to stimulate the extension of the right index finger and the electroencephalographic signal was simultaneously recorded. Results. A main effect was found for the condition, block and electrode in the centro-parietal junction, although we only found a main effect for condition and electrode in the temporo-parietal junction. Conclusion. Our results suggest that the functional coupling between the central and parietal areas is directly connected to the priming memory function, although the coupling between temporal and parietal areas is related to the working memory.
- Lack of systematic topographic difference between attention and reasoning beta correlates(2012) BASILE, L. F. H.; ALVARENGA, M. Y.; HENRIQUE JR., N.; PASQUINI, H. A.; ALFENAS, W.Based on previous evidence for individual-specific sets of cortical areas active during simple attention tasks, in this work we intended to perform within individual comparisons of task-induced beta oscillations between visual attention and a reasoning task. Since beta induced oscillations are not time-locked to task events and were first observed by Fourier transforms, in order to analyze the cortical topography of attention induced beta activity, we have previously computed corrected-latency averages based on spontaneous peaks of band-pass filtered epochs. We then used Independent Component Analysis (ICA) only to single out the significant portion of averaged data, above noise levels. In the present work ICA served as the main, exhaustive means for decomposing beta activity in both tasks, recorded by 128-channel EEG in 20 subjects. Given the previously observed similarity between tasks by visual inspection and by simple descriptive statistics, we now intended another quantitative approach: to statistically test whether each ICA component obtained in one task could be explained by a linear regression model based on the topographic patterns from the other task in each individual. Results confirmed the high topographic similarity between reasoning and attention beta correlates in that few components in some individuals (overall below 30%) were not satisfactorily explained by the complementary task, and if those could be considered “task-specific”, their scalp distribution and estimated cortical sources were not common across subjects. These findings, discussed along with those from task-related physiological studies based on individual data (and classical clinical observations), are compatible with the increasingly accepted view that individuals may use largely different sets of cortical association areas to perform a given task, but also with the new idea that those individual sets do not change much across tasks that differ in major psychological processes.
article 3 Citação(ões) na Scopus Gamma band oscillations in parietooccipital areas during performance of a sensorimotor integration task A qEEG coherence study(2011) TEIXEIRA, Silmar; VELASQUES, Bruna; MACHADO, Sergio; PAES, Flavia; CUNHA, Marlo; BUDDE, Henning; ANGHINAH, Renato; BASILE, Luis F. H.; CAGY, Mauricio; PIEDADE, Roberto; RIBEIRO, PedroThis study aimed to elucidate cortical mechanisms involved in anticipatory actions when 23 healthy right-handed subjects had to catch a free falling object through quantitative electroencephalogram (qEEG). For this reason, we used coherence that represents a measurement of linear covariation between two signals in the frequency domain. In addition, we investigated gamma-band (30-100 Hz) activity that is related to cognitive and somatosensory processes. We hypothesized that gamma coherence will be increase in both parietal and occipital areas during moment after ball drop, due to their involvement in manipulation of objects, visuospatial processing, visual perception, stimuli identification and attention processes. We confirmed our hypothesis, an increase in gamma coherence on P3-P4 (t=-2.15; p=0.033) and PZ-OZ (t=-2.16; p=0.034) electrode pairs was verified for a paired t-test. We conclude that to execute tasks involving anticipatory movements (feedforward mechanisms), like our own task, probably, there is no need of a strong participation of visual areas in the process of information organization to manipulate objects and to process visuospatial information regarding the contact hand-object.