CARMEN SILVIA MOLLEIS GALEGO MIZIARA
Projetos de Pesquisa
Unidades Organizacionais
LIM/40 - Laboratório de Imunohematologia e Hematologia Forense, Hospital das Clínicas, Faculdade de Medicina
14 resultados
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Agora exibindo 1 - 10 de 14
bookPart Documentos médicos e documentos médico-legais(2022) MIZIARA, Carmen Silvia Molleis Galego- Cognitive impact in children with ""benign"" childhood focal epilepsy with centrotemporal spikes(2017) BANASKIWITZ, Natalie Helene van Cleef; MIZIARA, Carmen Silvia Molleis Galego; XAVIER, Alana Batista; MANREZA, Maria Luiza Giraldes de; TREVIZOL, Alisson Paulino; DIAS, Alvaro Machado; SERAFIM, Antonio de PaduaBackground: Cognitive alterations are associated with benign childhood focal epilepsy with centrotemporal spikes (BCECTS) including aspects of executive functions. Objectives: This study presents the performance profile on attention and executive function tests of fifty-eight children (BCECTS, n = 30 and controls, n = 28) aged 8-13 years. Methods: The following tools were employed: Vocabulary and Block Design subtests from the Wechsler Intelligence Scale for Children III, Stroop Test, Modified Card Sorting Test, Controlled Oral Word Association - FAS and Tower of London. Results: Children with BCECTS presented average IQ measure, although their performance was statistically worse when compared to the control group. Children with BCECTS showed significantly lower performance compared to the control group in the following variables: total number of recollected words on the oral fluency test, total number of categories, categorization effect and total number of errors in MCST; and execution time for the Stroop Test Card 1. After controlling for the IQ effect, the total number of errors in the MCST did not show any significant difference between the groups. Discussion: Children with BCECTS showed lower performance in attention and executive functions when compared to healthy children. The results suggest that the concept of ""benign"" BCECTS should be reconsidered.
- Impact of benign childhood epilepsy with centrotemporal spikes (BECTS) on school performance(2012) MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes de; MANSUR, Leticia; REED, Umbertina Conti; GUILHOTO, Laura Maria Figueiredo Ferreira; SERRANO, Virginia Aparecida Gelmeti; GOIS, SolangeBECTS represents the vast majority of childhood focal epilepsy. Owing to the age peculiarity of children who suffer from this disease, i.e., school-going age of between 6 and 9 years, the condition is often referred to as a school disorder by parents and teachers. Objective: The aim of this study was to evaluate the academic performance of children with BED'S, according to the clinical and electroencephalographic ILAE criteria, and compare the results of neuropsychological tests of language and attention to the frequency of epileptic discharges. Methods: The performances of 40 school children with BED'S were evaluated by applying a school performance test (SBT), neuropsychological tests (WISC and Trail-Making), and language tests (Illinois Test Psycholinguistic Abilities - ITPA - and Staggered Spondaic Word - SSW). The same tests were applied in the control group. Results: Children with BED'S, when compared to those in the control group, showed lower scores in academic performance (SPT), digits and similarities subtests of WISC, auditory processing subtest of SSW, and ITPA - representational and automatic level. The study showed that epileptic discharges did not influence the results. Conclusion: Children with BED'S scored significantly lower scores in tests on academic performance, when compared with those in the control group probably due to executive dysfunction.
bookPart Epilepsias e Crises Epilépticas na Infância e Adolescência(2015) MIZIARA, Carmen Silvia Molleis Galego; SAMPAIO, Letícia Pereira de Brito; MANREZA, Maria Luiza Giraldes de- The Perceived Social Stigma of People with Epilepsy with regard to the Question of Employability(2018) SOUZA, Jessica Lopes de; FAIOLA, Aline Scardoeli; MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes deObjective. To evaluate the perceived social stigma of people with epilepsy with regard to the question of employability. Methods. A structured questionnaire was given to two groups of people with chronic diseases: those with epilepsy (study group) and those with heart disease (control group). The questions concerned employability. Results. Having epilepsy was more strongly associated with higher unemployment rates (p < 0.0001); job layoffs (p = 0.001); being unfit to work (p < 0.0001); feeling shame for having the disease (p = 0.014); absence of partners (p = 0.026); and depression (p = 0.004). The tendency to hide their disease from their employers was similar for the two groups. Conclusion. The age discrepancy between groups was an important limiting factor of this study. However, despite the limited number of participants and the age difference between the groups, there is no impediment in stating that people with epilepsy show high rates of unemployment, depression, and stigma.
- Considerations about ethical and legal aspects at the end of life during the COVID-19 pandemic(2021) MIZIARA, Ivan Dieb; MIZIARA, Carmen Silvia Molleis Galego
- Time Interval between First and Last Epileptic Seizures and Electroencephalogram Normalization in Benign Childhood Epilepsy with Centrotemporal Spikes: Influencing Factors(2020) MIZIARA, Carmen Silvia Molleis Galego; MICHELETTO, Maria Laura Jorge; SERRANO, Virginia Aparecida Gelmeti; NAKANISHI, Denise Harumi; SERINOLLI, Mario Ivo; MANREZA, Maria Luiza Giraldes de; REED, Umbertina ContiThe aim of this study was to evaluate the interval between the first and last seizures, the normalization of the electroencephalogram (EEG), and to identify factors of influence. Medical records of children were analyzed with benign childhood epilepsy with centrotemporal spikes. Variables age at first and last seizure, gender, interval between the first and last seizure, the first seizure and EEG normalization, lateralization of the epileptiform discharges, and last epileptic seizure and EEG normalization. The mean time between the first and last seizure was 3.34 years. Early onset of seizures and unilateral discharges were factors that increased the interval between the first and last seizures (p < 0.001). Interval between the last seizure and EEG normalization was 2.40 years, without influence of age (p = 0.986). Interval was shorter in bilateral discharges (p = 0.035). The antiepileptic medicine did not alter the natural history of disease progression. In younger children, the interval between last seizure and normalization of the EEG is reduced compared to older children.
conferenceObject DECISION MAKING IN ROLANDIC EPILEPSY(2013) LUNARDI, L.; FUENTES, D.; GUIMARAES, C.; BOSCARIOL, M.; MANREZA, M. L.; MIZIARA, C.; GUERREIRO, M.Purpose: The aim of this study was to evaluate the decision-making style in children with rolandic epilepsy (RE) and compare their performance with healthy children taking into account clinical variables of epilepsy. Method: We evaluated 42 children, 17 with RE (RE Group) and 25 healthy controls (Control Group). All children were assessed with the Iowa Gabling Task (IGT), the most used instrument to evaluate the decision-making style, and the Wechsler Intelligence Scale for Children (WISC-III) to investigate the intellectual level (estimated IQ). The clinical variables of epilepsy were: age of seizure onset and remission, type of seizure (partial vs. generalized), use of AED (none, monotherapy or polytherapy), and seizure lateralization (right, left, and bilateral). Results: No significant differences were found between the two groups. However, when analysing the RE group, we observed that the later the onset of epilepsy, the best style of decision making presented (p = 0.04). The same was true when comparing the intellectual level of the RE group: the higher the IQ, the better the decision-making style (p = 0.02). Conclusion: We conclude that although RE is known as a benign entity, difficulty in decision-making ability may be observed. More studies are necessary to corroborate our findings.- Oral dyspraxia in self-limited epilepsy with centrotemporal spikes: a comparative study with a control group(2021) BERNARDO, Henrique Nicola Santo Antonio; MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes de; MANSUR, Leticia LessaBackground: self-limited epilepsy with centrotemporal spikes, previously considered benign focal childhood epilepsy with centrotemporal spikes show clinical signs of involvement of Rolandic areas, mainly lower area, which may affect the planning and execution of motor sequences. Objective:This study aimed to evaluated oral praxis in children with self-limited epilepsy with centrotemporal spikes and compare to the age-matched control group. Methods: This was a descriptive study with 74 children with self-limited epilepsy with centrotemporal spikes, with the classical forms according to International League Against Epilepsy, and between 4 and 15 years of age, selected from the child neurology outpatient clinic of the Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, and 239 age-matched and educational level-matched (convenience sampling) control children. All children were submitted to the battery of oral volitional movements, which consisted of 44 tests for oral movement (tongue, lip, cheek, jaw, and palate) and 34 phonemes and consonant cluster tasks, with simple and sequenced oral movements. Results: The mean age and standard deviation (SD) of children with epilepsy was 9.08 years (SD 2.55) and of controls 9.61 years (SD 3.12). The results showed significant differences between the groups with a poorer performance of children with epilepsy compared to children without epilepsy in simple and particularly in sequenced movements. Conclusion: These findings can be attributed to the genetically determined immaturity of cortical structures related to motor planning in children with self-limited epilepsy with centrotemporal spikes.
- Sequential motor task (Luria's Fist-Edge-Palm Test) in children with benign focal epilepsy of childhood with centrotemporal spikes(2013) MIZIARA, Carmen Silvia Molleis Galego; MANREZA, Maria Luiza Giraldes de; MANSUR, Leticia; REED, Umbertina Conti; BUCHPIGUEL, Carlos AlbertoThis study evaluated the sequential motor manual actions in children with benign focal epilepsy of childhood with centrotemporal spikes (BECTS) and compares the results with matched control group, through the application of Luria's fist-edge-palm test. The children with BECTS underwent interictal single photon emission computed tomography (SPECT) and School Performance Test (SPT). Significant difference occurred between the study and control groups for manual motor action through three equal and three different movements. Children with lower school performance had higher error rate in the imitation of hand gestures. Another factor significantly associated with the failure was the abnormality in SPECT. Children with BECTS showed abnormalities in the test that evaluated manual motor programming/planning. This study may suggest that the functional changes related to epileptiform activity in rolandic region interfere with the executive function in children with BECTS.