RICARDO ROMITI
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/50 - Laboratório de Patologia das Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina
LIM/53 - Laboratório de Micologia, Hospital das Clínicas, Faculdade de Medicina
LIM/50 - Laboratório de Patologia das Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina
127 resultados
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- Evidence for neurogenic inflammation in lichen planopilaris and frontal fibrosing alopecia pathogenic mechanism(2020) DOCHE, Isabella; WILCOX, George L.; ERICSON, Marna; VALENTE, Neusa S.; ROMITI, Ricardo; MCADAMS, Brian. D.; HORDINSKY, Maria K.Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic scarring alopecias affecting primarily the scalp. Although both diseases may share some clinical and histopathological features, in the last decade, FFA has become an ""epidemic"" particularly in Europe, North and South America with unique clinical manifestations compared to LPP, thus, raising the idea that this disease may have a different pathogenesis. Symptoms such as scalp burning, pruritus or pain are usually present in both diseases, suggesting a possible role for nerves and neuropeptides in the pathogenesis of both diseases. Based on some previous studies, neuropeptides, such as substance P (SP) and calcitonin gene-related peptide (CGRP), have been associated with lipid metabolism and many chronic inflammatory disorders. In this study, we asked if these neuropeptides are associated with LPP and FFA scalp lesions. Alteration in the expression of SP and CGRP in affected and unaffected scalp skin from patients with both diseases was found with examination of sections using immunohistochemical techniques and confocal microscopy. We then quantitatively assessed and compared SP and CGRP expression from control, LPP and FFA scalp biopsies. Although LPP and FFA share similar histopathologic findings, opposite results were found in affected and unaffected scalp in the ELISA tests, suggesting that these diseases may have different pathogenic mechanisms. We also found presence of histopathological inflammation irrespective of evident clinical lesions, which raises the possibility that both diseases may be more generalized processes affecting the scalp.
- Extensive cutaneous involvement by dermatomyositis: Report of six cases and review of the literature(2020) MIYASHIRO, Denis; ARNONE, Marcelo; FERREIRA, Paula Silva; ROMITI, Ricardo; SANCHES, Jose Antonio
- Efficacy and safety of fixed-dose combination calcipotriol/betamethasone dipropionate foam for the treatment of psoriasis(2021) GOLD, L. Stein; PAUL, C.; ROMITI, R.The fixed-dose combination calcipotriol (Cal; 50 mu g/g) plus betamethasone dipropionate (BD; 0.5 mg/g) ointment and gel formulations have well-established efficacy profiles in the treatment of psoriasis vulgaris (chronic plaque psoriasis); this combination has been shown to produce favourable outcomes versus either monotherapy. To improve upon the efficacy and cosmetic acceptability of these treatments Cal/BD foam was developed, demonstrating superior efficacy in Phase II/III studies compared with either of its monocomponents, Cal/BD ointment, Cal/BD gel and various other therapies for the treatment of psoriasis. Multiple outcome measures were evaluated in the clinical studies, including physician's global assessment of disease severity and modified psoriasis area and severity index. Of note, 38-55% of patients across studies achieved a physician's global assessment of 'clear' or 'almost clear' after 4 weeks of Cal/BD treatment. This superior efficacy was not associated with an increased frequency or severity of adverse events, and there was no evidence for dysregulation of the hypothalamic-pituitary-adrenal axis or calcium homeostasis. Overall, Cal/BD foam was efficacious, with a good tolerability profile consistent with established Cal/BD formulations.
- Generalized Lenticular Atrophoderma of Pasini and Pierini(2015) AVANCINI, Joao; VALENTE, Neusa Yuriko S.; ROMITI, RicardoWe present a 16-year-old boy with multiple, well-circumscribed, atrophic, light-brown patches on his neck, chest, and back. The authors believe that it represents an unusual presentation of atrophoderma of Pasini and Pierini and suggest the designation generalized lenticular APP.
bookPart Dermatoses Eritematodescamativas(2018) ROMITI, Ricardo; MARAGNO, Luciana- Generalized pustular psoriasis (von Zumbusch)(2022) ROMITI, Ricardo; HIRAYAMA, Andre Luis da Silva; ARNONE, Marcelo; MAGALHAES, Renata FerreiraGeneralized pustular psoriasis (von Zumbusch) is a rare and acute eruption characterized by multiple sterile pustules over an erythematous and edematous background, eventually associated with psoriasis vulgaris. Classically, it manifests as a potentially severe systemic picture and demands prompt diagnosis and intervention. The duration of each flare-up and intervals between the pustular episodes is extremely variable. Recently, genetic abnormalities have been identified mainly in the familial and early variants of this disease. The therapeutic arsenal is limited; however, new drugs being evaluated aim to control both pustular flare-ups and disease recurrences. (C) 2021 Sociedade Brasileira de Dermatologia.
- Infliximab-induced psoriasis during therapy for Crohn's disease(2012) STEINWURZ, Flavio; DENADAI, Rafael; SAAD-HOSSNE, Rogerio; QUEIROZ, Maria Luiza; TEIXEIRA, Fabio Vieira; ROMITI, RicardoAlthough therapy with tumor necrosis factor-alpha inhibitors (anti-TNF) provides beneficial effects in different immune inflammatory disorders, paradoxical cases of anti-THE-induced psoriasis have increasingly been reported, mostly in the setting of rheumatologic diseases. To date, less than 50 cases of infliximab-induced psoriasis in inflammatory bowel disease patients have been described. The present report was aimed at describing two new cases of infliximab-induced psoriasis during therapy for Crohn's disease and at carrying out a review on this intriguing phenomenon.
- Assessment of psoriasis severity in Brazilian patients with chronic plaque psoriasis attending outpatient clinics: a multicenter, population-based cross-sectional study (APPISOT)(2018) ROMITI, Ricardo; FABRICIO, Lincoln Helder Zambaldi; SOUZA, Cacilda da Silva; GALVAO, Leticia Oba; CASTRO, Caio Cesar Silva de; TERENA, Aripuana Coberio; CARNEIRO, Francisca Regina Oliveira; OYAFUSO, Luiza Keiko Matsuka; CARNEIRO, Sueli; GONTIJO, Bernardo; KOBATA, Clarice Marie; OLIVEIRA, Maria de Fatima Paim de; CESTARI, Tania; ANTONIO, Joao Roberto; MARTINS, Gladys Aires; MARQUES, Silvio Alencar; CHAIBUB, Sulamita Costa Wirth; ARRUDA, Ana Carolina Belini Bazan; FELIX, Paulo Antonio Oldani; MAGALHAES, Renata Ferreira; ABULAFIA, Luna Azulay; FERREIRA, Karine A.; SILVA, Aline Medeiros da; SILVA, Bruno Leonardo; SOUZA, JulianoPurpose: Data on chronic plaque psoriasis severity and its potential clinical and lifestyle implications in the Brazilian population are limited. The primary aim of this study was to assess the clinical severity of plaque psoriasis in Brazil. Further objectives included evaluating potential associations between disease severity and demographic, lifestyle, and clinical characteristics, health-related quality of life (HRQOL), and work productivity. Materials and methods: This observational (non-interventional) cross-sectional study was conducted in 26 dermatologic clinics across 11 Brazilian states. Psoriasis severity was assessed using investigator judgment and Finlay's Rule of Tens: a Psoriasis Area and Severity Index (PASI) score >10, a Body Surface Area (BSA) > 10%, or a Dermatology Life Quality Index (DLQI) score >10. Results: Among 1125 patients, 205 (18.2%) had moderate-to-severe disease. On multiple regression analyses, psoriasis severity was significantly (directly) associated with the presence of physical inactivity and comorbid pain, anxiety, and depression; and significantly (inversely) associated with HRQOL and work productivity. Limitations: Cross-sectional studies cannot assess temporal trends, and observational studies cannot conclusively determine causality or exclude biases and confounding due to unmeasured variables. Conclusions: Among Brazilian patients with moderate-to-severe psoriasis, disease severity had far-reaching adverse impacts on lifestyle, comorbidities, HRQOL, and work productivity.
conferenceObject Scalp neuropathy in dermatomyositis patients with recalcitrant scalp pruritus(2018) CIRINO, Pablo; WIPF, Angela; ROMITI, Ricardo; MCADAMS, Brian; FOSTER, Shawn; KENNEDY, William; HORDINSKY, MariaconferenceObject Patient perception and the importance of clear/almost clear skin as a treatment goal in moderate-to-severe plaque psoriasis: results of the 'Clear about Psoriasis' worldwide patient survey(2017) ARMSTRONG, A.; JARVIS, S.; BOEHNCKE, W-H; RAJAGOPALAN, M.; FERNANDEZ-PENAS, P.; ROMITI, R.; BEWLEY, A.; O'DONNELL, M.; HUNEAULT, L.; DEKKER, E.; SODHA, M.; WARREN, R. B.