CARLOS SHIMIZU

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Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 15
  • conferenceObject
    Evaluation of an AI system for breast cancer screening in mammograms of young women.
    (2020) PETRINI, Daniel Gustavo Pellacani; VALENTE, Gabriel Vansuita; SHIMIZU, Carlos; ROELA, Rosimeire Aparecida; ARAUJO, Gabriel Miranda de; TUCUNDUVA, Tatiana Cardoso de Mello; FOLGUEIRA, Maria A. A. Koike; KIM, Hae Yong
  • article 3 Citação(ões) na Scopus
    Core needle biopsy in fibroepithelial tumors: predicting factors for phyllodes tumors
    (2021) REIS, Yedda Nunes; MAESAKA, Jonathan Yugo; SHIMIZU, Carlos; SOARES-JUNIOR, Jose Maria; BARACAT, Edmund Chada; FILASSI, Jose Roberto
    OBJECTIVES: This study aimed to evaluate the clinical and imaging predictive factors for the diagnosis of phyllodes tumors in patients with inconclusive results from core needle biopsy (fibroepithelial lesions). METHODS: We retrospectively analyzed data of patients who underwent surgical excision of breast lesions previously diagnosed as fibroepithelial lesions. Numeric variables were analyzed using the Shapiro-Wilk and t-tests, and categorical variables were analyzed using the chi-square and Fisher's exact tests. Multivariate logistic regression was performed to calculate odds ratios and detect predictive factors for the diagnosis of PT. RESULTS: A total of 89 biopsy samples were obtained from 77 patients, of which 43 were confirmed as fibroadenomas, 43 as phyllodes tumors, and 3 as other benign, non-fibroepithelial breast lesions. The mean tumor size was 3.61 cm (range, 0.8-10 cm) for phyllodes tumors and 2.4 cm (range, 0.8-7.9 cm) for fibroadenomas. The predictive factor for phyllodes tumor diagnosis was lesion size >3 cm (p< 0.001). CONCLUSION: Our data indicate that fibroepithelial lesions of the breast larger than 3 cm are more likely to be phyllodes tumors.
  • conferenceObject
    Brazilian randomized study: Impact of preoperative magnetic resonance in the evaluation for breast cancer conservative surgery (BREAST-MRI Trial)
    (2019) MOTA, B. S.; REIS, Y. N.; DORIA, M. T.; RICCI, M. D.; SHIMIZU, C.; FERREIRA, V.; TUCUNDUVA, T.; BARROS, N. de; BARACAT, E. C.; FILASSI, J. R.
  • conferenceObject
    Brazilian Randomized Study - BREAST-MRI Trial - Impact of Preoperative Magnetic Resonance in the Evaluation for Breast Cancer Conservative Surgery: Local recurrence and surgical outcomes
    (2023) MOTA, Bruna S.; REIS, Yedda N.; BARROS, Nestor; CARDOSO, Natalia; MOTA, Rosa S.; SHIMIZU, Carlos; TUCUNDUVA, Tatiana; GONCALVES, Rodrigo; DORIA, Maira T.; FERREIRA, Vera; RICCI, Marcos; TRINCONI, Angela; RIERA, Rachel; BARACAT, Edmund C.; SOARES JR., Jose Maria; FILASSI, Jose Roberto
  • article 6 Citação(ões) na Scopus
    Pre-treatment MRI tumor features and post-treatment mammographic findings: may they contribute to refining the prediction of pathologic complete response in post-neoadjuvant breast cancer patients with radiologic complete response on MRI?
    (2022) THOMPSON, Bruna M.; CHALA, Luciano F.; SHIMIZU, Carlos; MANO, Max S.; FILASSI, Jose R.; GEYER, Felipe C.; TORRES, Ulysses S.; MELLO, Giselle Guedes Netto de; LEITE, Claudia da Costa
    Purpose Radiologic complete response (rCR) in breast cancer patients after neoadjuvant chemotherapy (NAC) does not necessarily correlate with pathologic complete response (pCR), a marker traditionally associated with better outcomes. We sought to verify if data extracted from two important steps of the imaging workup (tumor features at pre-treatment MRI and post-treatment mammographic findings) might assist in refining the prediction of pCR in post-NAC patients showing rCR. Methods A total of 115 post-NAC women with rCR on MRI (2010-2016) were retrospectively assessed. Pre-treatment MRI (lesion morphology, size, and distribution) and post-treatment mammographic findings (calcification, asymmetry, mass, architectural distortion) were assessed, as well as clinical and molecular variables. Bivariate and multivariate analyses evaluated correlation between such variables and pCR. Post-NAC mammographic findings and their correlation with ductal in situ carcinoma (DCIS) were evaluated using Pearson's correlation. Results Tumor distribution at pre-treatment MRI was the only significant predictive imaging feature on multivariate analysis, with multicentric lesions having lower odds of pCR (p = 0.035). There was no significant association between tumor size and morphology with pCR. Mammographic residual calcifications were associated with DCIS (p = 0.009). The receptor subtype remained as a significant predictor, with HR-HER2 + and triple-negative status demonstrating higher odds of pCR on multivariate analyses. Conclusions Multicentric lesions on pre-NAC MRI were associated with a lower chance of pCR in post-NAC rCR patients. The receptor subtype remained a reliable predictor of pCR. Residual mammographic calcifications correlated with higher odds of malignancy, making the correlation between mammography and MRI essential for surgical planning.
  • conferenceObject
    Brazilian randomized study - Impact of preoperative magnetic resonance in the evaluation for breast cancer conservative surgery (BREAST-MRI trial)
    (2018) DORIA, Maira T.; MOTA, Bruna S.; REIS, Yedda N.; RICCI, Marcos D.; PIATO, Jose R. M.; FERREIRA, Vera C. C. S.; SHIMIZU, Carlos; BARROS, Nestor; FILASSI, Jose R.; BARACAT, Edmund C.
  • conferenceObject
    End-to-end training of convolutional network for breast cancer detection in two-view mammography.
    (2021) PETRINI, Daniel G.; SHIMIZU, Carlos; VALENTE, Gabriel V.; FOLGUEIRA, Guilherme; NOVAES, Guilherme A.; KATAYAMA, Maria L.; SERIO, Pedro; ROELA, Rosimeire A.; TUCUNDUVA, Tatiana C.; FOLGUEIRA, Maria Aparecida A.; KIM, Hae Y.
  • article 32 Citação(ões) na Scopus
    AXILLARY LYMPH NODE SONOGRAPHIC FEATURES AND BREAST TUMOR CHARACTERISTICS AS PREDICTORS OF MALIGNANCY: A NOMOGRAM TO PREDICT RISK
    (2017) TEIXEIRA, Patricia Akissue de Camargo; CHALA, Luciano F.; SHIMIZU, Carlos; FILASSI, Jose R.; MAESAKA, Jonathan Y.; BARROS, Nestor de
    The purpose of this study was to build a mathematical model to predict the probability of axillary lymph node metastasis based on the ultrasonographic features of axillary lymph nodes and the tumor characteristics. We included 74 patients (75 axillae) with invasive breast cancer who underwent axillary ultrasonography ipsilateral to the tumor and fine-needle aspiration of one selected lymph node. Lymph node pathology results from sentinel lymph node biopsy or surgical dissection were correlated with lymph node ultrasonographic data and with the cytologic findings of fine-needle aspiration. Our mathematical model of prediction risk of lymph node metastasis included only pre-surgical data from logistic regression analysis: lymph node cortical thickness (p = 0.005), presurgical tumor size (p = 0.030), menopausal status (p = 0.017), histologic type (p = 0.034) and tumor location (p = 0.011). The area under the receiver operating characteristic curve of the model was 0.848, reflecting an excellent discrimination of the model. This nomogram may assist in the choice of the optimal axillary approach. (E-mail: pakissue@gmail.com) (C) 2017 World Federation for Ultrasound in Medicine & Biology.
  • article 5 Citação(ões) na Scopus
    Effects of preoperative magnetic resonance image on survival rates and surgical planning in breast cancer conservative surgery: randomized controlled trial (BREAST-MRI trial)
    (2023) MOTA, Bruna Salani; REIS, Yedda Nunes; BARROS, Nestor de; CARDOSO, Natalia Pereira; MOTA, Rosa Maria Salani; SHIMIZU, Carlos; TUCUNDUVA, Tatiana Cardoso de Mello; FERREIRA, Vera Christina Camargo de Siqueira; GONCALVES, Rodrigo; DORIA, Maira Teixeira; RICCI, Marcos Desiderio; TRINCONI, Angela Francisca; CAMARGO, Cristina Pires; RIERA, Rachel; BARACAT, Edmund Chada; JR, Jose Maria Soares; FILASSI, Jose Roberto
    BackgroundBreast magnetic resonance imaging (MRI) has high sensitivity in detecting invasive neoplasms. Controversy remains about its impact on the preoperative staging of breast cancer surgery. This study evaluated survival and surgical outcomes of preoperative MRI in conservative breast cancer surgery.MethodsA phase III, randomized, open-label, single-center trial including female breast cancer participants, stage 0-III disease, and eligible for breast-conserving surgery. We compared the role of including MRI in preoperative evaluation versus radiologic exam routine with mammography and ultrasound in breast cancer conservative candidates. The primary outcome was local relapse-free survival (LRFS), and secondary outcomes were overall survival (OS), mastectomy rate, and reoperation rate.Results524 were randomized to preoperative MRI group (n = 257) or control group (n = 267). The survival analysis showed a 5.9-years LRFS of 99.2% in MRI group versus 98.9% in control group (HR = 0.72; 95% CI 0.12-4.28; p = 0.7) and an OS of 95.3% in the MRI group versus 96.3% in the control group (HR = 1.37 95% CI 0.59-3.19; p = 0.8). Surgical management changed in 21 ipsilateral breasts in the MRI group; 21 (8.3%) had mastectomies versus one in the control group. No difference was found in reoperation rates, 22 (8.7%) in the MRI group versus 23 (8.7%) in the control group (RR = 1.002; 95% CI 0.57-1.75; p = 0.85).ConclusionPreoperative MRI increased the mastectomy rates by 8%. The use of preoperative MRI did not influence local relapse-free survival, overall survival, or reoperation rates.
  • conferenceObject
    High-accuracy breast cancer detection in mammography using EfficientNet and end-to-end training.
    (2021) PETRINI, Daniel G.; SHIMIZU, Carlos; VALENTE, Gabriel V.; FOLGUEIRA, Guilherme; NOVAES, Guilherme A.; KATAYAMA, Maria L.; SERIO, Pedro; ROELA, Rosimeire A.; TUCUNDUVA, Tatiana C.; FOLGUEIRA, Maria Aparecida A.; KIM, Hae Y.