TANIA LEME DA ROCHA MARTINEZ
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conferenceObject APPLICATION OF A MULTILEVEL HIERARCHICAL MODEL TO CORRELATE TOTAL CHOLESTEROL IN EIGHT DIFFERENT SETTINGS(2016) PEREIRA, A.; GUARNIERI, F.; MELLO, A. P. Q.; SANTOS FILHO, R.; MARTINEZ, T. L. R.- Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population(2012) FERREIRA, Noely E.; OMAE, Samantha; PEREIRA, Abel; RODRIGUES, Mariliza V.; MIYAKAWA, Ayumi A.; CAMPOS, Luciene C. G.; SANTOS, Paulo C. J. L.; DALLAN, Luiz A.; MARTINEZ, Tania L.; SANTOS, Raul D.; MILL, Jose G.; KRIEGER, Jose E.; PEREIRA, Alexandre C.Objective: To investigate the relationship between TXNIP polymorphisms, diabetes and hypertension phenotypes in the Brazilian general population. Methods: Five hundred seventy-six individuals randomly selected from the general urban population according to the MONICA-WHO project guidelines were phenotyped for cardiovascular risk factors. A second, independent, sample composed of 487 family-trios from a different site was also selected. Nine TXNIP polymorphisms were studied. The potential association between TXNIP variability and glucose-phenotypes in children was also explored. TXNIP expression was quantified by real-time PCR in 53 samples from human smooth muscle cells primary culture. Results: TXNIP rs7211 and rs7212 polymorphisms were significantly associated with glucose and blood pressure related phenotypes. In multivariate logistic regression models the studied markers remained associated with diabetes even after adjustment for covariates. TXNIP rs7211 T/rs7212 G haplotype (present in approximately 17% of individuals) was significantly associated to diabetes in both samples. In children, the TXNIP rs7211 T/rs7212 G haplotype was associated with fasting insulin concentrations. Finally, cells harboring TXNIP rs7212 G allele presented higher TXNIP expression levels compared with carriers of TXNIP rs7212 CC genotype (p = 0.02). Conclusion: Carriers of TXNIP genetic variants presented higher TXNIP expression, early signs of glucose homeostasis derangement and increased susceptibility to chronic metabolic conditions such as diabetes and hypertension. Our data suggest that genetic variation in the TXNIP gene may act as a ""common ground"" modulator of both traits: diabetes and hypertension.
conferenceObject SODIUM INTAKE AND PREVALENCE OF HYPERTENSION IN ELEMENTARY SCHOOL STUDENTS(2014) PEREIRA, A.; PEREIRA, T. C.; ELIAS, M. C.; IHARA, S. S. M.; MACHADO, C. A.; SANTOS FILHO, R. D.; PEREIRA, F. O. C.; MARTINEZ, T. L. R.conferenceObject IMPACT OF SOCIAL AND CLINICAL PARAMETERS ON NON-HDL CHOLESTEROL IN SCHOOL CHILDREN(2016) PEREIRA, A.; GUARNIERI, F.; MELLO, A. P. Q.; SANTOS FILHO, R.; MARTINEZ, T. L. R.- V Diretriz Brasileira de Dislipidemias e Prevenção da Aterosclerose(2013) XAVIER, H. T.; IZAR, M. C.; FARIA NETO, J. R.; ASSAD, M. H.; ROCHA, V. Z.; SPOSITO, A. C.; FONSECA, F. A.; DOS SANTOS, J. E.; SANTOS, R. D.; BERTOLAMI, M. C.; FALUDI, A. A.; MARTINEZ, T. L. R.; DIAMENT, J.; GUIMARÃES, A.; FORTI, N. A.; MORIGUCHI, E.; CHAGAS, A. C. P.; COELHO, O. R.; RAMIRES, J. A. F.
conferenceObject CORRELATION BETWEEN FOOD CONSUMPTION, BODY MASS INDEX AND WAIST CIRCUMFERENCE IN PRESCHOOL AND SCHOOL CHILDREN IN PUBLIC SCHOOLS(2014) PEREIRA, A.; CAMARGO, T. P.; ELIAS, M. C.; IHARA, S. S. M.; MACHADO, C. A.; SANTOS FILHO, R. D.; MARTINEZ, T. L. R.conferenceObject ETHICAL SURVEY OF HIGH CHOLESTEROL AND RISK ESTIMATION FOR FAMILIAL HYPERCHOLESTEROLEMIA IN 6320 STUDENTS OF AGES FROM 6 TO 19 YEARS(2014) PEREIRA, A.; CAMARGO, T. P.; IHARA, S. S. M.; ELIAS, M. C.; PINTO, L. E. S. Almeida; MACHADO, C. A.; SANTOS FILHO, R. D.; FERNANDES, S.; MARTINEZ, T. L. R.conferenceObject PROPOSAL OF A NEW APPROACH TO ACCESS CHOLESTEROL RANGES ACCORDING TO DIFFERENT CONDITIONS(2016) PEREIRA, A.; GUARNIERI, F.; MELLO, A. P. Q.; SANTOS FILHO, R.; MARTINEZ, T. L. R.conferenceObject COMPARISON BETWEEN TOTAL DIETARY INTAKE AND SERUM CHOLESTEROL LEVELS IN ELEMENTARY AND MIDDLE SCHOOL STUDENTS(2014) PEREIRA, A.; PEREIRA, F. O. C.; PEREIRA, T. C.; ELIAS, M. C.; IHARA, S. S. M.; MACHADO, C. A.; SANTOS FILHO, R. D.; MARTINEZ, T. L. R.conferenceObject IMPACT OF A DECADE OF ACTION ON PREVENTION OF HYPERTENSION AND ANTHROPOMETRY OF SCHOOL STUDENTS(2014) PEREIRA, A.; CAMARGO, T. P.; ELIAS, M. C.; IHARA, S. S. M.; MACHADO, C. A.; SANTOS FILHO, R. D.; MARTINEZ, T. L. R.