Thioredoxin interacting protein genetic variation is associated with diabetes and hypertension in the Brazilian general population

Imagem de Miniatura
Arquivos
art_FERREIRA_Thioredoxin_interacting_protein_genetic_variation_is_associated_with_2012_eng.pdf (253.61 KB)
Citações na Scopus
41
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER IRELAND LTD
Autores
PEREIRA, Abel
Citação
ATHEROSCLEROSIS, v.221, n.1, p.131-136, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective: To investigate the relationship between TXNIP polymorphisms, diabetes and hypertension phenotypes in the Brazilian general population. Methods: Five hundred seventy-six individuals randomly selected from the general urban population according to the MONICA-WHO project guidelines were phenotyped for cardiovascular risk factors. A second, independent, sample composed of 487 family-trios from a different site was also selected. Nine TXNIP polymorphisms were studied. The potential association between TXNIP variability and glucose-phenotypes in children was also explored. TXNIP expression was quantified by real-time PCR in 53 samples from human smooth muscle cells primary culture. Results: TXNIP rs7211 and rs7212 polymorphisms were significantly associated with glucose and blood pressure related phenotypes. In multivariate logistic regression models the studied markers remained associated with diabetes even after adjustment for covariates. TXNIP rs7211 T/rs7212 G haplotype (present in approximately 17% of individuals) was significantly associated to diabetes in both samples. In children, the TXNIP rs7211 T/rs7212 G haplotype was associated with fasting insulin concentrations. Finally, cells harboring TXNIP rs7212 G allele presented higher TXNIP expression levels compared with carriers of TXNIP rs7212 CC genotype (p = 0.02). Conclusion: Carriers of TXNIP genetic variants presented higher TXNIP expression, early signs of glucose homeostasis derangement and increased susceptibility to chronic metabolic conditions such as diabetes and hypertension. Our data suggest that genetic variation in the TXNIP gene may act as a ""common ground"" modulator of both traits: diabetes and hypertension.
Palavras-chave
Diabetes, Hypertension, Polymorphism
URI
https://observatorio.fm.usp.br/handle/OPI/283
Referências
  1. Alvim RO, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-128
  2. Barrett JC, 2005, BIOINFORMATICS, V21, P263, DOI 10.1093/bioinformatics/bth457
  3. Buckle A, 2007, HEART LUNG CIRCULATI, V16, pS214, DOI 10.1016/j.hlc.2007.06.512
  4. Campos LCG, 2009, CARDIOVASC RES, V83, P140, DOI 10.1093/cvr/cvp108
  5. CHEN KS, 1994, BBA-GENE STRUCT EXPR, V1219, P26, DOI 10.1016/0167-4781(94)90242-9
  6. Coon H, 2004, ATHEROSCLEROSIS, V174, P357, DOI 10.1016/j.atherosclerosis.2004.02.004
  7. De Flines J., ACTA GASTROENTEROL B, V73, P261
  8. Glumer C, 2003, DIABETES CARE, V26, P2335, DOI 10.2337/diacare.26.8.2335
  9. Harrison DG, 2005, NAT MED, V11, P375, DOI 10.1038/nm0405-375
  10. Junn E, 2000, J IMMUNOL, V164, P6287
  11. MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
  12. MCKENZIE KJ, 1994, BRIT MED J, V309, P286
  13. Minn AH, 2005, BIOCHEM BIOPH RES CO, V336, P770, DOI 10.1016/j.bbrc.2005.08.161
  14. Minn AH, 2006, BIOCHEMISTRY-US, V45, P11047, DOI 10.1021/bi0603625
  15. Mochizuki M, 2009, ANTIOXID REDOX SIGNA
  16. Mokdad AH, 2003, JAMA-J AM MED ASSOC, V289, P76, DOI 10.1001/jama.289.1.76
  17. Moser M, 1999, J CLIN HYPERTENS GRE, V1, P48
  18. Parikh H, 2007, PLOS MED, V4, P868, DOI 10.1371/journal.pmed.0040158
  19. Redon J, 2003, HYPERTENSION, V41, P1096, DOI 10.1161/01.HYP.0000068370.21009.38
  20. Rich SS, 2006, J AM SOC NEPHROL, V17, P353, DOI 10.1681/ASN.2005070770
  21. Schulze PC, 2004, J BIOL CHEM, V279, P30369, DOI 10.1074/jbc.M400549200
  22. Shalev A, 2002, ENDOCRINOLOGY, V143, P3695, DOI 10.1210/en.2002-220564
  23. TUNSTALLPEDOE H, 1994, CIRCULATION, V90, P583
  24. van Greevenbroek MMJ, 2007, DIABETIC MED, V24, P498, DOI 10.1111/j.1464-5491.2007.02109.x
  25. World CJ, 2006, J MOL MED-JMM, V84, P997, DOI 10.1007/s00109-006-0109-6
  26. Yamawaki H, 2005, J CLIN INVEST, V115, P733, DOI 10.1172/JCI200523001
  27. Yamawaki H, 2005, CURR OPIN NEPHROL HY, V14, P149, DOI 10.1097/00041552-200503000-00010
  28. Yasunari K, 2002, HYPERTENSION, V39, P777, DOI 10.1161/hy0302.104670
  29. Zidek W, 2009, CARDIOVASC DIABETOL, V8, DOI 10.1186/1475-2840-8-51

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/11
Artigos e Materiais de Revistas Científicas - LIM/13