AMANDA VITORIA LACERDA DE ARAUJO
Projetos de Pesquisa
Unidades Organizacionais
LIM/45 - Laboratório de Fisiopatologia Neurocirúrgica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Level of knowledge and misconceptions about brain concussion in Brazilian adults(2021) ARAUJO, Amanda Vitoria Lacerda De; AREZA-FEGYVERES, Renata; GUARIGLIA, Carla Cristina; IANOF, Jessica Natuline; BARATHO, Regina Maria; DEMARIO, Jose Luiz Carlos; WATANABE, Rafael Gustavo Sato; ANGHINAH, RenatoBackground: Brain concussion (BC) is seen as a public health priority due to its high incidence and morbidity rate, among thousands of people around the world. There are needs for fast identification, accurate diagnosis and correct management in order to reduce the short and long-term problems relating to BC. Proper knowledge of BC in the population and among clinicians is a critical factor in achieving this. Objectives: To evaluate the level of self-reported BC knowledge and gaps/misconceptions, and to identify variables correlated with this level. Methods: A cross-sectional descriptive survey was performed. A Brain Concussion Knowledge Questionnaire (BCKQ) that had been created to capture data was widely distributed. Total scores, domain partial scores and percentages of correct and incorrect answers were calculated to ascertain the level of knowledge relating to BC. Results: The sample was formed by 1,247 Brazilian adults (age: 41.7 +/- 11.8 years). Partial scores of the BCKQ revealed the existence of poor knowledge and misconceptions in all domains of the questionnaire, especially regarding questions about recovery from and management of BC. Moderate correlations between BCKQ scores and professions (p=0.312; P=0.00) or previous brain concussion knowledge (p=0.489; P=0.00) were observed. In a multiple linear regression model, age, profession and sports practice were predictors of BC knowledge. Conclusion: This first study to analyze the level of BC knowledge in a sample of Brazilian adults suggests that poor knowledge and misconceptions are present. Thus, meaningful and useful information was provided by this study for developing health education programs about BC for the population in order to improve fast diagnosis and correct BC management.
- Deep learning of resting-state electroencephalogram signals for three-class classification of Alzheimer's disease, mild cognitive impairment and healthy ageing(2021) HUGGINS, Cameron J.; ESCUDERO, Javier; PARRA, Mario A.; SCALLY, Brian; ANGHINAH, Renato; ARAUJO, Amanda Vitoria Lacerda De; BASILE, Luis F.; ABASOLO, DanielObjective. This study aimed to produce a novel deep learning (DL) model for the classification of subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI) subjects and healthy ageing (HA) subjects using resting-state scalp electroencephalogram (EEG) signals. Approach. The raw EEG data were pre-processed to remove unwanted artefacts and sources of noise. The data were then processed with the continuous wavelet transform, using the Morse mother wavelet, to create time-frequency graphs with a wavelet coefficient scale range of 0-600. The graphs were combined into tiled topographical maps governed by the 10-20 system orientation for scalp electrodes. The application of this processing pipeline was used on a data set of resting-state EEG samples from age-matched groups of 52 AD subjects (82.3 +/- 4.7 years of age), 37 MCI subjects (78.4 +/- 5.1 years of age) and 52 HA subjects (79.6 +/- 6.0 years of age). This resulted in the formation of a data set of 16197 topographical images. This image data set was then split into training, validation and test images and used as input to an AlexNet DL model. This model was comprised of five hidden convolutional layers and optimised for various parameters such as learning rate, learning rate schedule, optimiser, and batch size. Main results. The performance was assessed by a tenfold cross-validation strategy, which produced an average accuracy result of 98.9 +/- 0.4% for the three-class classification of AD vs MCI vs HA. The results showed minimal overfitting and bias between classes, further indicating the strength of the model produced. Significance. These results provide significant improvement for this classification task compared to previous studies in this field and suggest that DL could contribute to the diagnosis of AD from EEG recordings.
- Efficacy of Virtual Reality Rehabilitation after Spinal Cord Injury: A Systematic Review(2019) ARAUJO, Amanda Vitoria Lacerda de; NEIVA, Jaqueline Freitas de Oliveira; MONTEIRO, Carlos Bandeira de Mello; MAGALHAES, Fernando HenriqueBackground. Spinal cord injury (SCI) is often associated with long-term impairments related to functional limitations in the sensorimotor system. The use of virtual reality (VR) technology may lead to increased motivation and engagement, besides allowing a wide range of possible tasks/exercises to be implemented in rehabilitation programs. The present review aims to investigate the possible benefits and efficacy of VR-based rehabilitation in individuals with SCI. Methods. An electronically systematic search was performed in multiple databases (PubMed, BVS, Web of Science, Cochrane Central, and Scielo) up to May 2019. MESH terms and keywords were combined in a search strategy. Two reviewers independently selected the studies in accordance with eligibility criteria. The PEDro scale was used to score the methodological quality and risk of bias of the selected studies. Results. Twenty-five studies (including 482 participants, 47.6 +/- 9.5 years, 73% male) were selected and discussed. Overall, the studies used VR devices in different rehabilitation protocols to improve motor function, driving skills, balance, aerobic function, and pain level, as well as psychological and motivational aspects. A large amount of heterogeneity was observed as to the study design, VR protocols, and outcome measures used. Only seven studies (28%) had an excellent/good quality of evidence. However, substantial evidence for significant positive effects associated with VR therapy was found in most of the studies (88%), with no adverse events (88%) being reported. Conclusion. Although the current evidence is limited, the findings suggest that VR-based rehabilitation in subjects with SCI may lead to positive effects on aerobic function, balance, pain level, and motor function recovery besides improving psychological/motivational aspects. Further high-quality studies are needed to provide a guideline to clinical practice and to draw robust conclusions about the potential benefits of VR therapy for SCI patients. Protocol details are registered on PROSPERO (registration number: ).
- Use of anodal transcranial direct current stimulation: Features, facets, and applications to incomplete spinal cord injury(2022) ARAúJO, A. V. L. de; ABILIO, M. dos Santos; NASCIMENTO, D. A. do; BARBOSA, V. R. N.; YORK, B. S. de Albuquerque Cacique NewMotor and sensory function impairments after an incomplete spinal cord injury generate a significant reduction in the functionality and quality of life, especially in a portion of working-age individuals. The development of research about effective interventions and adequate management should be a priority to rehabilitation postinjury. Anodal Transcranial Direct Current Stimulation, a low-intensity direct current, has been considered a noninvasive, painless, and safe stimulation. The anodal transcranial direct current stimulation effects appear to be related to modulation of the depolarization threshold in the neuronal membrane. Neuroplasticity in the neuronal circuit has been reported also. The potential to promote neuroplasticity by modulating the cortical excitability and motor descending pathways such as the corticospinal tract has an important place in rehabilitation. Therefore, stimuli to neuroplasticity to improve the effectiveness of rehabilitation after incomplete spinal cord injury should be investigated. Currently, anodal transcranial direct current stimulation effects on the cortical excitability, neuroplasticity, motor function, or functionality, and chronic neuropathic pain appear to reduce impairments after incomplete spinal cord injury. Studies should observe the short-, medium-, and long-term effects potentially related to the anodal transcranial direct current stimulation to define the therapy value to clinical practice. Besides, the cost-effectiveness and adherence level should be considered in future research. © 2022 Elsevier Inc. All rights reserved.
- Systematic Review of the Main Motor Scales for Clinical Assessment of Individuals with down Syndrome(2020) MORIYAMA, Cristina Hamamura; MASSETTI, Thais; CROCETTA, Tania Brusque; SILVA, Talita Dias Da; MUSTACCHI, Zan; GUARNIERI, Regiani; ABREU, Luiz Carlos De; ARAUJO, Amanda Vitoria Lacerda De; MENEZES, Lilian Del Ciello De; MONTEIRO, Carlos Bandeira De Mello; LEONE, ClaudioObjective: The aim of the present review was to identify the motor scales currently used to assess individuals with Down Syndrome (DS). Method: PubMed, WOS and BVS databases were systematically searched to identify the most relevant published studies that used motor scales in the evaluation of individuals with DS. Results: Of the 99 studies that met the eligibility criteria in this process, 20 experimental and observational studies were found to fully meet the eligibility criteria. Conclusion: We identified several motor scales including the Alberta Infant Motor Scale (AIMS), Test of Infant Motor Performance (TIMP), BAYLEY, Peabody Gross Motor Scale (PGMS-PDMS-GM), Gross Motor Function Measure (GMFM), Movement Assessment Battery for Children (MABC) and Pediatric Evaluation of Disability Inventory (PEDI).
- Effectiveness of anodal transcranial direct current stimulation to improve muscle strength and motor functionality after incomplete spinal cord injury: a systematic review and meta-analysis(2020) ARAUJO, Amanda Vitoria Lacerda De; RIBEIRO, Felipe Piccarone Goncalves; MASSETTI, Thais; POTTER-BAKER, Kelsey A.; CORTES, Mar; PLOW, Ela Bhatt; SILVA, Talita Dias Da; TONKS, James; ANGHINAH, Renato; MAGALHAES, Fernando Henrique; FREGNI, Felipe; MONTEIRO, Carlos Bandeira De MelloStudy design Systematic review and meta-analysis. Objectives We aimed to investigate the effects of anodal transcranial direct current stimulation (tDCS) against sham on muscle strength and motor functionality after incomplete spinal cord injury (iSCI). Setting University of Sao Paulo, Brazil. Methods A preplanned protocol was registered (PROSPERO, CRD42016050444). Pubmed, Embase, Web of Science, Cochrane Central Library and BVS databases were searched independently by two authors up to March 2018. Cochrane Collaboration's Tool was used for the risk of bias assessments. Generic inverse variance and random-effects model were used to calculate pooled effect sizes (ES), 95% confidence intervals (CIs) and p-values in meta-analyses. Results Six randomized clinical trials met inclusion criteria (n = 78 iSCI individuals) and were included in the meta-analysis. Results showed a marginal significant pooled effect of active tDCS in improving motor functionality with a small ES (SMD = 0.26, 95% CI = -0.00 to 0.53, p = 0.05, I-2 = 0%). On the other hand, the pooled effect of active tDCS on muscle strength did not reach statistical significance, in parallel with a small ES (SMD = 0.35, 95% CI = -0.21 to 0.92, p = 0.22, I-2 = 0%) when compared with sham tDCS. No significant adverse events were reported. Conclusions Overall, there was a significant effect of tDCS in improving motor functionality following iSCI. However, a small ES and the marginal p-value suggest that these results should be interpreted with caution. Further high-quality clinical trials are needed to support or refute the use of tDCS in daily clinical practice.