Sonothrombolysis for acute ischemic stroke: a systematic review of randomized controlled trials

Imagem de Miniatura
Arquivos
art_BOR-SENG-SHU_Sonothrombolysis_for_acute_ischemic_stroke_a_systematic_review_2012.PDF (952.02 KB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
AMER ASSOC NEUROLOGICAL SURGEONS
Autores
Citação
NEUROSURGICAL FOCUS, v.32, n.1, article ID E5, 6p, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Object. Sonothrombolysis has recently been considered an emerging modality for the treatment of stroke. The purpose of the present paper was to review randomized clinical studies concerning the effects of sonothrombolysis associated with tissue plasminogen activator (tPA) on acute ischemic stroke. Methods. Systematic searches for literature published between January 1996 and July 2011 were performed for studies regarding sonothrombolysis combined with tPA for acute ischemic stroke. Only randomized controlled trials were included. Data extraction was based on ultrasound variables, patient characteristics, and outcome variables (rate of intracranial hemorrhages and arterial recanalization). Results. Four trials were included in this study; 2 trials evaluated the effect of transcranial Doppler (TCD) ultrasonography on sonothrombolysis, and 2 addressed transcranial color-coded duplex (TCCD) ultrasonography. The frequency of ultrasound waves varied from 1.8 to 2 MHz. The duration of thrombus exposure to ultrasound energy ranged from 60 to 120 minutes. Sample sizes were small, recanalization was evaluated at different time points (60 and 120 minutes), and inclusion criteria were heterogeneous. Sonothrombolysis combined with tPA did not lead to an increase in symptomatic intracranial hemorrhagic complications. Two studies demonstrated that patients treated with ultrasound combined with tPA had statistically significant higher rates of recanalization than patients treated with tPA alone. Conclusions. Despite the heterogeneity and the limitations of the reviewed studies, there is evidence that sonothrombolysis associated with tPA is a safe procedure and results in an increased rate of recanalization in the setting of acute ischemic stroke when wave frequencies and energy intensities of diagnostic ultrasound systems are used. (http://thejns.org/doi/abs/10.3171/2011.10.FOCUS11251)
Palavras-chave
sonothrombolysis, stroke, transcranial color-coded duplex, transcranial Doppler ultrasonography
URI
https://observatorio.fm.usp.br/handle/OPI/787
Referências
  1. Alexandrov AV, 2008, STROKE, V39, P1464, DOI 10.1161/STROKEAHA.107.505727
  2. Alexandrov AV, 2006, INT J STROKE, V1, P26, DOI 10.1111/j.1747-4949.2005.00012.x
  3. Alexandrov AV, 2004, NEW ENGL J MED, V351, P2170, DOI 10.1056/NEJMoa041175
  4. Alexandrov AV, 2000, STROKE, V31, P610
  5. Barsottini OGP, 2011, CLIN NEUROL NEUROSUR, V113, P404, DOI 10.1016/j.clineuro.2010.11.015
  6. BLINC A, 1993, BLOOD, V81, P2636
  7. Bor-Seng-Shu E, 2011, NEUROSURGERY, V69, pE501, DOI 10.1227/NEU.0b013e31821b7ed1
  8. Bor-Seng-Shu E, 2004, ARQ NEURO-PSIQUIAT, V62, P715
  9. Bor-Seng-Shu E, 2006, J NEUROSURG, V104, P93, DOI 10.3171/jns.2006.104.1.93
  10. Bor-Seng-Shu E, 2010, ACTA NEUROCHIR, V152, P2085, DOI 10.1007/s00701-010-0736-0
  11. Culp WC, 2011, STROKE, V42, P2280, DOI 10.1161/STROKEAHA.110.607150
  12. Culp WC, 2004, STROKE, V35, P2407, DOI 10.1161/01.STR.0000140890.86779.79
  13. Daffertshofer M, 2003, LANCET NEUROL, V2, P283, DOI 10.1016/S1474-4422(03)00380-6
  14. Daffertshofer M, 2005, STROKE, V36, P1441, DOI 10.1161/01.STR.0000170707.86793.1a
  15. Eggers J, 2008, STROKE, V39, P1470, DOI 10.1161/STROKEAHA.107.503870
  16. Eggers J, 2003, ANN NEUROL, V53, P797, DOI 10.1002/ana.10590
  17. FRANCIS CW, 1995, ULTRASOUND MED BIOL, V21, P419, DOI 10.1016/0301-5629(94)00119-X
  18. HOLLAND CK, 2009, P IEEE INT S BIOM IM, P755
  19. Jagannathan J, 2009, NEUROSURGERY, V64, P201, DOI 10.1227/01.NEU.0000336766.18197.8E
  20. Larrue V, 2007, STROKE, V38, P472
  21. Medel R, 2009, NEUROSURGERY, V65, P979, DOI 10.1227/01.NEU.0000350226.30382.98
  22. Molina CA, 2006, STROKE, V37, P425, DOI 10.1161/01.STR.0000199064.94588.39
  23. Molina CA, 2009, ANN NEUROL, V66, P28, DOI 10.1002/ana.21723
  24. Newell DW, 2011, J NEUROSURG, V115, P592, DOI 10.3171/2011.5.JNS10505
  25. Rha JH, 2007, STROKE, V38, P967, DOI 10.1161/01.STR.0000258112.14918.24
  26. Soltani A, 2011, J THROMB THROMBOLYS, V31, P71, DOI 10.1007/s11239-010-0483-3
  27. Tsivgoulis G, 2008, ULTRASONICS, V48, P303, DOI 10.1016/j.ultras.2007.11.008
  28. Tsivgoulis G, 2007, NEUROTHERAPEUTICS, V4, P420, DOI 10.1016/j.nurt.2007.05.012
  29. Tsivgoulis G, 2010, STROKE, V41, P280, DOI 10.1161/STROKEAHA.109.563304

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/26