The Burden of Uncontrolled Cardiovascular Risk Factors in Men With Prostate Cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKLIMIS, Harry
dc.contributor.authorPINTHUS, Jehonathan H.
dc.contributor.authorAGHEL, Nazanin
dc.contributor.authorDUCEPPE, Emmanuelle
dc.contributor.authorFRADET, Vincent
dc.contributor.authorBROWN, Ian
dc.contributor.authorSIEMENS, D. Robert
dc.contributor.authorSHAYEGAN, Bobby
dc.contributor.authorKLOTZ, Laurence
dc.contributor.authorLUKE, Patrick P.
dc.contributor.authorNIAZI, Tamim
dc.contributor.authorLAVALLEE, Luke T.
dc.contributor.authorMOUSAVI, Negareh
dc.contributor.authorHAMILTON, Robert J.
dc.contributor.authorCHIN, Joseph L.
dc.contributor.authorGOPAUL, Darin
dc.contributor.authorVIOLETTE, Philippe D.
dc.contributor.authorDAVIS, Margot K.
dc.contributor.authorHANNA, Nawar
dc.contributor.authorSABBAGH, Robert
dc.contributor.authorZADOK, Osnat Itzhaki Ben
dc.contributor.authorHAJJAR, Ludhmila Abrahao
dc.contributor.authorKANN, Ariel Galapo
dc.contributor.authorMIAN, Rajibul
dc.contributor.authorRANGARAJAN, Sumathy
dc.contributor.authorHUEI, Kelvin Kuan
dc.contributor.authorIAKOBISHVILI, Zaza
dc.contributor.authorSELVANAYAGAM, Joseph B.
dc.contributor.authorAVEZUM, Alvaro
dc.contributor.authorLEONG, Darryl P.
dc.date.accessioned2023-06-21T14:07:02Z
dc.date.available2023-06-21T14:07:02Z
dc.date.issued2023
dc.description.abstractBACKGROUND Cardiovascular disease (CVD) incidence is higher in men with prostate cancer (PC) than without. OBJECTIVES We describe the rate and correlates of poor cardiovascular risk factor control among men with PC. METHODS We prospectively characterized 2,811 consecutive men (mean age 68 +/- 8 years) with PC from 24 sites in Canada, Israel, Brazil, and Australia. We defined poor overall risk factor control as >= 3 of the following: suboptimal low-density lipoprotein cholesterol (>2 mmol/L if Framingham Risk Score [FRS] >= 15 and >= 3.5 mmol/L if FRS <15), current smoker, physical inactivity (<600 MET min/wk), suboptimal blood pressure (BP) (>= 140/90 mm Hg if no other risk factors, systolic BP >= 120 mm Hg if known CVD or FRS >= 15, and >= 130/80 mm Hg if diabetic), and waist:hip ratio >0.9. RESULTS Among participants (9% with metastatic PC and 23% with pre-existing CVD), 99% had >= 1 uncontrolled cardiovascular risk factor, and 51% had poor overall risk factor control. Not taking a statin (odds ratio [OR]: 2.55; 95% CI: 2.00-3.26), physical frailty (OR: 2.37; 95% CI: 1.51-3.71), need for BP drugs (OR: 2.36; 95% CI: 1.84-3.03), and age (OR per 10-year increase: 1.34; 95% CI: 1.14-1.59) were associated with poor overall risk factor control after adjustment for education, PC characteristics, androgen deprivation therapy, depression, and Eastern Cooperative Oncology Group functional status. CONCLUSIONS Poor control of modifiable cardiovascular risk factors is common in men with PC, highlighting the large gap in care and the need for improved interventions to optimize cardiovascular risk management in this population. (J Am Coll Cardiol CardioOnc 2023;5:70-81) (c) 2023 The Authors.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipProstate Cancer Canada [CT2015-01]
dc.description.sponsorshipMovember Foundation
dc.description.sponsorshipHamilton Health Sciences (Research Strategic Initiative Program)
dc.description.sponsorshipCanadian Cancer Society [706677]
dc.description.sponsorshipAFP Fellowship Award, Department of Cardiology, McMaster University
dc.description.sponsorshipBiotronik
dc.description.sponsorshipBayer
dc.description.sponsorshipSanofi
dc.description.sponsorshipActelion
dc.description.sponsorshipNovartis
dc.description.sponsorshipClive Kearon Career Award, Department of Medicine, McMaster University
dc.identifier.citationJACC: CARDIOONCOLOGY, v.5, n.1, p.70-81, 2023
dc.identifier.doi10.1016/j.jaccao.2022.09.008
dc.identifier.issn2666-0873
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53869
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofJacc: Cardiooncology
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIEReng
dc.subjectandrogen deprivation therapyeng
dc.subjectcardiovascular disease preventioneng
dc.subjectcardiovascular riskeng
dc.subjectprospectiveeng
dc.subjectprostate cancereng
dc.subject.otherandrogen-deprivation therapyeng
dc.subject.otheramerican-heart-associationeng
dc.subject.othersociety guidelineseng
dc.subject.otherblood-pressureeng
dc.subject.otherdiseaseeng
dc.subject.otherpreventioneng
dc.subject.otherepidemiologyeng
dc.subject.othermanagementeng
dc.subject.othermortalityeng
dc.subject.otherfrailtyeng
dc.subject.wosOncologyeng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titleThe Burden of Uncontrolled Cardiovascular Risk Factors in Men With Prostate Cancereng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryIsrael
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisoil
hcfmusp.affiliation.countryisoau
hcfmusp.author.externalKLIMIS, Harry:McMaster Univ & Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada
hcfmusp.author.externalPINTHUS, Jehonathan H.:McMaster Univ, Dept Surg, Hamilton, ON, Canada
hcfmusp.author.externalAGHEL, Nazanin:McMaster Univ & Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada; McMaster Univ & Hamilton Hlth Sci, Dept Med, Hamilton, ON, Canada
hcfmusp.author.externalDUCEPPE, Emmanuelle:McMaster Univ & Hamilton Hlth Sci, Dept Med, Hamilton, ON, Canada; Univ Montreal, Dept Med, Montreal, PQ, Canada
hcfmusp.author.externalFRADET, Vincent:Univ Laval, Dept Surg, Quebec City, PQ, Canada; Univ Laval, Res Ctr CHU Quebec, Oncol Axis, Quebec City, PQ, Canada; CHU Quebec, LHotel Dieu Quebec Site, Quebec City, PQ, Canada
hcfmusp.author.externalBROWN, Ian:Niagara Hlth Syst, Div Urol, St Catharines, ON, Canada
hcfmusp.author.externalSIEMENS, D. Robert:Queens Canc Res Inst, Kingston, ON, Canada; Queens Univ, Dept Biomed & Mol Sci, Kingston, ON, Canada; McMaster Univ, Dept Surg, Div Urol, St Josephs Healthcare, Hamilton, ON, Canada
hcfmusp.author.externalSHAYEGAN, Bobby:Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Surg, Div Urol, Toronto, ON, Canada
hcfmusp.author.externalKLOTZ, Laurence:Western Univ, London Hlth Sci Ctr, Div Urol, Div Urol, London, ON, Canada
hcfmusp.author.externalLUKE, Patrick P.:Rabin Med Ctr, Dept Cardiol, Radiat Oncol Dept, Dept Community Cardiol, Tel Aviv Jaffa Dist, Petah Tiqwa, PQ, Israel
hcfmusp.author.externalNIAZI, Tamim:Univ Sao Paulo, Dept Cardiol, Inst Coracao, Dept Surg, Sao Paulo, ON, Brazil
hcfmusp.author.externalLAVALLEE, Luke T.:Hosp Alemao Oswaldo Cruz, Dept Med, Div Cardiol, Sao Paulo, PQ, Brazil
hcfmusp.author.externalMOUSAVI, Negareh:Univ Toronto, Princess Margaret Canc Ctr, Dept Surg, Div Urol, Toronto, ON, Canada
hcfmusp.author.externalHAMILTON, Robert J.:Univ Western Ontario, London Hlth Sci Ctr, Dept Urol, London, ON, Canada
hcfmusp.author.externalCHIN, Joseph L.:Grand River Reg Canc Ctr, Dept Med, Div Radiat Oncol, Kitchener, ON, Canada
hcfmusp.author.externalVIOLETTE, Philippe D.:McMaster Univ, Dept Surg, Hamilton, ON, Canada
hcfmusp.author.externalSELVANAYAGAM, Joseph B.:South Australian Hlth & Med Res Inst, Dept Heart Hlth, Adelaide, SA, Australia
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcLUDHMILA ABRAHAO HAJJAR
hcfmusp.description.beginpage70
hcfmusp.description.endpage81
hcfmusp.description.issue1
hcfmusp.description.volume5
hcfmusp.origemWOS
hcfmusp.origem.pubmed36875906
hcfmusp.origem.scopus2-s2.0-85147561118
hcfmusp.origem.wosWOS:000944285800001
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
hcfmusp.relation.referenceAfilalo J, 2014, J AM COLL CARDIOL, V63, P747, DOI 10.1016/j.jacc.2013.09.070eng
hcfmusp.relation.referenceAhisar Y, 2021, J NUTR HEALTH AGING, V25, P1023, DOI 10.1007/s12603-021-1673-8eng
hcfmusp.relation.referenceAnderson TJ, 2013, CAN J CARDIOL, V29, P151, DOI 10.1016/j.cjca.2012.11.032eng
hcfmusp.relation.referenceArnett DK, 2019, CIRCULATION, V140, pE596, DOI [10.1161/CIR.0000000000000678, 10.1161/CIR.0000000000000677, 10.1016/j.jacc.2019.03.010, 10.1016/j.jacc.2019.03.009]eng
hcfmusp.relation.referenceBui AL, 2011, NAT REV CARDIOL, V8, P30, DOI 10.1038/nrcardio.2010.165eng
hcfmusp.relation.referenceButler SS, 2021, CANCER-AM CANCER SOC, V127, P2213, DOI 10.1002/cncr.33486eng
hcfmusp.relation.referenceCanadian Cardiovascular Society, FRAM RISK SCOReng
hcfmusp.relation.referenceCheung AS, 2013, ANDROLOGY-US, V1, P583, DOI 10.1111/j.2047-2927.2013.00093.xeng
hcfmusp.relation.referenceChow CK, 2013, JAMA-J AM MED ASSOC, V310, P959, DOI 10.1001/jama.2013.184182eng
hcfmusp.relation.referenceCirne F, 2022, EUR HEART J-CARD PHA, V8, P253, DOI 10.1093/ehjcvp/pvab005eng
hcfmusp.relation.referenceCriqui MH, 2015, CIRC RES, V116, P1509, DOI 10.1161/CIRCRESAHA.116.303849eng
hcfmusp.relation.referenceFervaha G, 2021, CUAJ-CAN UROL ASSOC, V15, P181, DOI 10.5489/cuaj.6912eng
hcfmusp.relation.referenceFolsom AR, 2011, J AM COLL CARDIOL, V57, P1690, DOI 10.1016/j.jacc.2010.11.041eng
hcfmusp.relation.referenceFried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146eng
hcfmusp.relation.referenceGansevoort RT, 2013, LANCET, V382, P339, DOI 10.1016/S0140-6736(13)60595-4eng
hcfmusp.relation.referenceGaye B, 2017, J AM COLL CARDIOL, V69, P3015, DOI 10.1016/j.jacc.2017.05.011eng
hcfmusp.relation.referenceGuo LL, 2017, CLIN CARDIOL, V40, P1339, DOI 10.1002/clc.22836eng
hcfmusp.relation.referenceHallal PC, 2012, LANCET, V380, P247, DOI 10.1016/S0140-6736(12)60646-1eng
hcfmusp.relation.referenceHoulden RL, 2018, CAN J DIABETES, V42, pS1, DOI 10.1016/j.jcjd.2017.10.001eng
hcfmusp.relation.referenceIPAQ Research Committee, 2005, GUIDELINES DATA PROCeng
hcfmusp.relation.referenceKlimis H, 2021, AM HEART J, V242, P33, DOI 10.1016/j.ahj.2021.08.009eng
hcfmusp.relation.referenceKroenke K, 2001, J GEN INTERN MED, V16, P606, DOI 10.1046/j.1525-1497.2001.016009606.xeng
hcfmusp.relation.referenceLeong DP, 2020, J UROLOGY, V203, P1109, DOI 10.1097/JU.0000000000000714eng
hcfmusp.relation.referenceLevine GN, 2010, CIRCULATION, V121, P833, DOI 10.1161/CIRCULATIONAHA.109.192695eng
hcfmusp.relation.referenceOKEN MM, 1982, AM J CLIN ONCOL-CANC, V5, P649, DOI 10.1097/00000421-198212000-00014eng
hcfmusp.relation.referenceOrkaby AR, 2019, J GERONTOL A-BIOL, V74, P373, DOI 10.1093/gerona/gly134eng
hcfmusp.relation.referencePearson GJ, 2021, CAN J CARDIOL, V37, P1129, DOI 10.1016/j.cjca.2021.03.016eng
hcfmusp.relation.referencePinthus JH, 2016, J CLIN ONCOL, V34, DOI 10.1200/jco.2016.34.2_suppl.178eng
hcfmusp.relation.referencePODSIADLO D, 1991, J AM GERIATR SOC, V39, P142, DOI 10.1111/j.1532-5415.1991.tb01616.xeng
hcfmusp.relation.referenceRabi DM, 2020, CAN J CARDIOL, V36, P596, DOI 10.1016/j.cjca.2020.02.086eng
hcfmusp.relation.referenceSoysal P, 2016, AGEING RES REV, V31, P1, DOI 10.1016/j.arr.2016.08.006eng
hcfmusp.relation.referenceSun LV, 2021, JAMA NETW OPEN, V4, DOI 10.1001/jamanetworkopen.2021.0070eng
hcfmusp.relation.referenceTownsend RR, 2020, HYPERTENSION, V76, P1667, DOI 10.1161/HYPERTENSIONAHA.120.14650eng
hcfmusp.relation.referenceUchmanowicz B, 2019, INT J HYPERTENS, V2019, DOI 10.1155/2019/5245184eng
hcfmusp.relation.referenceVan Hemelrijck M, 2010, J CLIN ONCOL, V28, P3448, DOI 10.1200/JCO.2010.29.1567eng
hcfmusp.relation.referenceVisseren FL., 2021, EUR HEART J, V42, P3227, DOI [DOI 10.1093/EURHEARTJ/EHAB484, DOI 10.1093/eurjpc/zwab154, 10.1093/eurheartj/ehab484]eng
hcfmusp.relation.referenceWeiner AB, 2021, CANCER-AM CANCER SOC, V127, P2895, DOI 10.1002/cncr.33584eng
hcfmusp.relation.referenceWong CM, 2008, ENVIRON HEALTH PERSP, V116, P1189, DOI 10.1289/ehp.10850eng
hcfmusp.relation.referenceYusuf S, 2004, LANCET, V364, P937, DOI 10.1016/S0140-6736(04)17018-9eng
hcfmusp.relation.referenceYusuf S, 2020, LANCET, V395, P795, DOI 10.1016/S0140-6736(19)32008-2eng
hcfmusp.relation.referenceYusuf S, 2016, NEW ENGL J MED, V374, P2032, DOI 10.1056/NEJMoa1600177eng
hcfmusp.relation.referenceZhang KW, 2020, CIRCULATION, V142eng
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