Reversible Pulmonary Trunk Banding VIII: Intermittent Overload Causes Harmless Hypertrophy in Adult Goat

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMIANA, Leonardo A.
dc.contributor.authorASSAD, Renato S.
dc.contributor.authorABDUCH, Maria C. D.
dc.contributor.authorSILVA, Gustavo J. J.
dc.contributor.authorNOGUEIRA, Ananda R.
dc.contributor.authorAIELLO, Vera D.
dc.contributor.authorMOREIRA, Luiz Felipe P.
dc.date.accessioned2013-09-23T16:36:34Z
dc.date.available2013-09-23T16:36:34Z
dc.date.issued2013
dc.description.abstractBackground. Traditional pulmonary artery banding (PAB) is not always suitable for mature subpulmonary ventricle retraining. We sought to assess in detail the myocardial morphologic adaptations of two different protocols for inducing right ventricular (RV) hypertrophy in an adult animal model. Methods. Eighteen adult goats were distributed into three groups: sham (no systolic overload), traditional (continuous systolic overload), and intermittent (daily 12-hour systolic overload). Systolic overload was adjusted to achieve a 0.7 RV-to-aortic pressure ratio. All animals underwent weekly echocardiographic studies, and hemodynamic evaluations were performed 3 times a week. After 4 weeks, the animals were humanely killed for morphologic assessment. Results. A 37.2% increase was observed in the RV wall thickness of the intermittent group (p < 0.05), but no significant echocardiographic changes were observed in the other two groups. The intermittent and traditional groups had a 55.7% and 36.7% increase in RV mass, respectively, compared with the sham group (p < 0.05). No differences were observed in myocardial water content of the three groups (p = 0.27). RV myocardial fiber and nuclei diameters were increased in the intermittent group compared with the sham group (p < 0.05). The area of collagen deposition in the RV interstitium was increased 98% in traditional group compared with the sham group (p < 0.05). No significant cellular proliferation occurred in any group. Conclusions. This study suggests that a more effective and harmless hypertrophy can be achieved in adult animals using intermittent PAB compared with the traditional approach. (Ann Thorac Surg 2013;95:1422-8) (c) 2013 by The Society of Thoracic Surgeons
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo State Foundation for Research Support [FAPESP 06/54051-1]
dc.identifier.citationANNALS OF THORACIC SURGERY, v.95, n.4, p.1422-1428, 2013
dc.identifier.doi10.1016/j.athoracsur.2013.01.009
dc.identifier.issn0003-4975
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1817
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofAnnals of Thoracic Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subject.othercongenitally corrected transposition
dc.subject.othergreat-arteries
dc.subject.otherventricular hypertrophy
dc.subject.otherexperimental-model
dc.subject.othersenning operation
dc.subject.otherswitch
dc.subject.otherpressure
dc.subject.otherregurgitation
dc.subject.otherdysfunction
dc.subject.othermustard
dc.subject.wosCardiac & Cardiovascular Systems
dc.subject.wosRespiratory System
dc.subject.wosSurgery
dc.titleReversible Pulmonary Trunk Banding VIII: Intermittent Overload Causes Harmless Hypertrophy in Adult Goat
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSILVA, Gustavo J. J.:Univ Sao Paulo, Sch Med, Inst Heart, Lab Cardiovasc Surg Res,LIM 11, BR-05403000 Sao Paulo, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcLEONARDO AUGUSTO MIANA
hcfmusp.contributor.author-fmusphcRENATO SAMY ASSAD
hcfmusp.contributor.author-fmusphcMARIA CRISTINA DONADIO ABDUCH
hcfmusp.contributor.author-fmusphcANANDA RIGO NOGUEIRA
hcfmusp.contributor.author-fmusphcVERA DEMARCHI AIELLO
hcfmusp.contributor.author-fmusphcLUIZ FELIPE PINHO MOREIRA
hcfmusp.description.beginpage1422
hcfmusp.description.endpage1428
hcfmusp.description.issue4
hcfmusp.description.volume95
hcfmusp.origemWOS
hcfmusp.origem.pubmed23434258
hcfmusp.origem.scopus2-s2.0-84875341017
hcfmusp.origem.wosWOS:000317150600040
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-10
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