High frequency of deficient consumption and low blood levels of 25-hydroxyvitamin D in HIV-1-infected adults from Sao Paulo city, Brazil

Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make their nutritional diagnoses, including their vitamin D blood levels, and to estimate their consumption of vitamin D. The study included 98 HIV-1-infected subjects, followed at University of Sao Paulo Medical School -HC-FMUSP. We performed a nutritional evaluation, along with the determination of patients' serum 25-hydroxyvitamin D and calcium concentration, biochemical analyses, and an anthropometric assessment. In the medical interview a 24-hour food recall was used (R24) to estimate daily calorie intake, macronutrients, calcium, and vitamin D. A high level of vitamin D deficiency was observed in our patients: 83.4% of them had levels below 30 ng/ml; they also presented an increased risk of cardiovascular disease, along with a high consumption of dietary fat. Factors related to the virus itself and to the use of antiretroviral drugs may have contributed for the low vitamin D levels seen in our HIV-1-infected patients.

URI

https://observatorio.fm.usp.br/handle/OPI/11830

Referências

[Anonymous], 2013, MS SECR VIG SD PROG, V201, P66
[Anonymous], 2002, WHO, V3, P95
Bandeira Francisco, 2006, Arq Bras Endocrinol Metabol, V50, P640, DOI 10.1590/S0004-27302006000400009
Bueno AL, 2008, J PEDIAT, V84, P386, DOI [10.2223/JPED.1816, 10.1590/S0021-75572008000600003]
Calvo MS, 2005, J NUTR, V135, P310
Cozzolino M, 2003, AIDS, V17, P513, DOI 10.1097/01.aids.0000050817.06065.f8
Deckers MML, 2013, CLIN CHIM ACTA, V426, P41, DOI 10.1016/j.cca.2013.08.024
Deeks S. G., 2009, BMJ-BRIT MED J, V338, P186
Gautam N, 2014, INDIAN J PEDIATR, V81, P1315, DOI 10.1007/s12098-014-1407-6
Havers F, 2014, J INFECT DIS, V210, P244, DOI 10.1093/infdis/jiu259
Holick MF, 2006, PROG BIOPHYS MOL BIO, V92, P49, DOI 10.1016/j.pbiomolbio.2006.02.014
Holick MF, 2007, NEW ENGL J MED, V357, P266, DOI 10.1056/NEJMra070553
Holick MF, 2006, MAYO CLIN PROC, V81, P353
Kruzich LA, 2004, J AM DIET ASSOC, V104, P1554, DOI 10.1016/j.jada.2004.07.031
Ponda MP, 2014, J CLIN ENDOCR METAB, V99, P2494, DOI 10.1210/jc.2014-1181
Premaor Melissa Orlandin, 2006, Arq Bras Endocrinol Metabol, V50, P25, DOI 10.1590/S0004-27302006000100005
Rodriguez-Martinez MA, 2002, PHARMACOL THERAPEUT, V93, P37, DOI 10.1016/S0163-7258(02)00164-X
Soares FMG, 2013, AN BRAS DERMATOL, V88, P570, DOI 10.1590/abd1806-4841.2013895
Tedaldi EM, 2006, JAIDS-J ACQ IMM DEF, V43, P35, DOI 10.1097/01.qai.0000234084.11291.d4
Theodorou M, 2014, CLIN NUTR, V33, P274, DOI 10.1016/j.clnu.2013.04.018
van der Sande MAB, 2004, JAIDS-J ACQ IMM DEF, V37, P1288, DOI 10.1097/01.qai.0000122708.59121.03
Vieth R, 2006, PROG BIOPHYS MOL BIO, V92, P26, DOI 10.1016/j.pbiomolbio.2006.02.003
Villamor E, 2006, NUTR REV, V64, P226, DOI 10.1301/nr.2006.may.226-233
Wang TJ, 2008, CIRCULATION, V117, P503, DOI 10.1161/CIRCULATIONAHA.107.706127
Webb AR, 2006, PROG BIOPHYS MOL BIO, V92, P17, DOI 10.1016/j.pbiomolbio.2006.02.004

Coleções

Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/38
Artigos e Materiais de Revistas Científicas - LIM/56
Artigos e Materiais de Revistas Científicas - ODS/03

Página do item completo