Modulatory effects of 17?-estradiol on acute lung inflammation after total occlusion of the descending aorta in male rats

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANUNCIACAO, Lucas Ferreira da
dc.contributor.authorSOUSA, Marcelo Nunes de
dc.contributor.authorVIDAL-DOS-SANTOS, Marina
dc.contributor.authorARMSTRONG-JR, Roberto
dc.contributor.authorMOREIRA, Luiz Felipe Pinho
dc.contributor.authorCORREIA, Cristiano Jesus
dc.contributor.authorBREITHAUPT-FALOPPA, Ana Cristina
dc.date.accessioned2022-12-21T13:19:15Z
dc.date.available2022-12-21T13:19:15Z
dc.date.issued2022
dc.description.abstractAs a consequence of systemic inflammation caused by ischemia and reperfusion (I/R) due to aortic occlusion, the lungs can exhibit increased microvascular permeability, local release of pro-inflammatory mediators, and leukocyte infiltration. Lung tissue infiltration by activated neutrophils is followed by acute respiratory distress syndrome, which is linked to acute pulmonary microvascular damage, high mortality rates, and organ dysfunction. Previous studies have demonstrated that female sex hormones modulate the inflammatory response and that prophylactic treatment with 178-estradiol (E2) can prevent fatalities and preserve mesenteric perfusion and intestinal integrity after ischemia/reperfusion induced by aortic occlusion. In this study, we focused on the protective effects of estradiol after aortic ischemia/reperfusion by evaluating lung injury and endothelial al-terations. Upon anesthesia and mechanical ventilation, male rats were subjected to aortic occlusion for 20 min, followed by 2 h of reperfusion. In parallel, one group of rats received a single injection of estradiol (280 mu g/kg, i. v.) 30 min before ischemia. We observed increased serum concentrations of IL-18, IL-6 and IL-10 in the I/R rats and E2 was able to reduce them. E2 effects after 2 h of reperfusion resulted mainly in decreasing of edema, iNOS expression and preventing leukocyte infiltration. Overall, our data indicate that estradiol might be a supple-mentary approach to deal with systemic processes and lung deterioration.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo Pesquisa do Estado de Sao Paulo [FAPESP] [2020/11211-6, 2021/07455-0]
dc.description.sponsorship[2018/25759-3]
dc.identifier.citationINTERNATIONAL IMMUNOPHARMACOLOGY, v.113, article ID 109311, 9p, 2022
dc.identifier.doi10.1016/j.intimp.2022.109311
dc.identifier.eissn1878-1705
dc.identifier.issn1567-5769
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50447
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofInternational Immunopharmacology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIEReng
dc.subjectIschemia and Reperfusioneng
dc.subject17&betaeng
dc.subject-estradioleng
dc.subjectLung inflammationeng
dc.subjectiNOSeng
dc.subject.othernitric-oxideeng
dc.subject.otherintestinal ischemiaeng
dc.subject.otherpulmonary-edemaeng
dc.subject.otherestradioleng
dc.subject.other17-beta-estradioleng
dc.subject.otherpathogenesiseng
dc.subject.otherinjuryeng
dc.subject.othermodeleng
dc.subject.wosImmunologyeng
dc.subject.wosPharmacology & Pharmacyeng
dc.titleModulatory effects of 17?-estradiol on acute lung inflammation after total occlusion of the descending aorta in male ratseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcLUCAS FERREIRA DA ANUNCIACAO
hcfmusp.contributor.author-fmusphcMARCELO NUNES DE SOUSA
hcfmusp.contributor.author-fmusphcMARINA VIDAL DOS SANTOS
hcfmusp.contributor.author-fmusphcROBERTO ARMSTRONG JUNIOR
hcfmusp.contributor.author-fmusphcLUIZ FELIPE PINHO MOREIRA
hcfmusp.contributor.author-fmusphcCRISTIANO DE JESUS CORREIA
hcfmusp.contributor.author-fmusphcANA CRISTINA BREITHAUPT FALOPPA
hcfmusp.description.articlenumber109311
hcfmusp.description.volume113
hcfmusp.origemWOS
hcfmusp.origem.pubmed36252489
hcfmusp.origem.scopus2-s2.0-85140274676
hcfmusp.origem.wosWOS:000878199000001
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
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