Penile alterations with severe sperm abnormalities in antiphospholipid syndrome associated with systemic lupus erythematosus

Imagem de Miniatura
Arquivos
art_RABELO-JUNIOR_Penile_alterations_with_severe_sperm_abnormalities_in_antiphospholipid_2013.PDF (122.52 KB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER LONDON LTD
Autores
Citação
CLINICAL RHEUMATOLOGY, v.32, n.1, p.109-113, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
This study aims to perform global gonadal and sexual function assessments in systemic lupus erythematosus-related antiphospholipid syndrome (SLE-APS) patients. A cross-sectional study was conducted in ten SLE-APS male patients and 20 healthy controls. They were assessed by demographic data, clinical features, urological examination, sexual function, testicular ultrasound, seminal parameters, sperm antibodies, and hormone profile. The median of current age was similar in SLE-APS patients and controls with a higher frequency of erectile dysfunction in the former group (30 vs. 0 %, p = 0.029). The median penis circumference was significantly reduced in SLE-APS patients with erectile dysfunction compared to patients without this complication (8.17 vs. 9.14 cm, p = 0.0397). SLE-APS patients with previous arterial thrombosis had a significantly reduced median penis circumference compared to those without this complication (7.5 vs. 9.18 cm, p = 0.039). Comparing SLE-APS patients and controls, the former had a significant lower median of sperm concentration (41.1 vs. 120.06 x 10(6)/mL, p = 0.003), percentages of sperm motility (47.25 vs. 65.42 %, p = 0.047), normal sperm forms by WHO guidelines (11 vs. 23.95 %, p = 0.002), and Kruger criteria (2.65 vs. 7.65 %, p = 0.02). Regarding seminal analysis, the medians of sperm concentration and total sperm count were significantly lower in SLE-APS patients treated with intravenous cyclophosphamide vs. those untreated with this drug (p < 0.05). Therefore, we have observed a novel association of reduced penile size with erectile dysfunction and previous arterial thrombosis in SLE-APS patients. Penis assessment should be routinely done in SLE-APS patients with fertility problems. We also identified that intravenous cyclophosphamide underlies severe sperm alterations in these patients.
Palavras-chave
Antiphospholipid syndrome, Antisperm antibodies, Erectile dysfunction, Fertility, Penile, Sperm, Systemic lupus erythematosus
URI
https://observatorio.fm.usp.br/handle/OPI/1796
Referências
  1. Abdo CHN, 2007, J SEX MED, V4, P382, DOI 10.1111/j.1743-6109.2006.00414.x
  2. Aikawa NE, 2012, CLIN EXP RHEUMATOL, V30, P445
  3. Aikawa NE, 2010, CLIN EXP RHEUMATOL, V28, P571
  4. BOMBARDIER C, 1992, ARTHRITIS RHEUM, V35, P630, DOI 10.1002/art.1780350606
  5. El-Sakka AI, 2010, J ANDROL, V31, P324, DOI 10.2164/jandrol.109.008730
  6. Febronio MV, 2007, LUPUS, V16, P430, DOI 10.1177/0961203307079298
  7. Gladman D, 1996, ARTHRITIS RHEUM, V39, P363, DOI 10.1002/art.1780390303
  8. Haris EN, 1994, AM J CLIN PATHOL, V101, P616
  9. Hochberg MC, 1997, ARTHRITIS RHEUM, V40, P1725, DOI 10.1002/art.1780400928
  10. KRUGER TF, 1988, FERTIL STERIL, V49, P112
  11. Moraes AJP, 2008, BRAZ J MED BIOL RES, V41, P1142, DOI 10.1590/S0100-879X2008001200016
  12. Moraes AJP, 2010, CLIN EXP RHEUMATOL, V28, P441
  13. Nukumizu LA, 2012, SCAD J RHEU IN PRESS
  14. Rabelo CN, 2012, LUPUS, V21, P251, DOI 10.1177/0961203311422715
  15. Silva CA, 2010, ARTHRIT CARE RES, V62, P1682, DOI 10.1002/acr.20323
  16. Silva CA, 2011, RHEUMATOL INT, V31, P1037, DOI 10.1007/s00296-010-1389-2
  17. Silva CAA, 2002, LUPUS, V11, P419, DOI 10.1191/0961203302lu219oa
  18. Soares PMF, 2007, ARTHRITIS RHEUM, V56, P2352, DOI 10.1002/art.22660
  19. Suehiro RM, 2008, RHEUMATOLOGY, V47, P1692, DOI 10.1093/rheumatology/ken338
  20. Vecchi AP, 2011, LUPUS, V20, P512, DOI 10.1177/0961203310384121
  21. Wilson WA, 1999, ARTHRITIS RHEUM, V42, P1309, DOI 10.1002/1529-0131(199907)42:7<1309::AID-ANR1>3.0.CO;2-F
  22. Wisloff F, 2002, THROMB RES, V108, P263, DOI 10.1016/S0049-3848(02)00400-0
  23. World Health Organization (WHO), 1999, LAB MAN EX HUM SEM S, P1

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - HC/IPq
Carregar mais